Genetic determinants of essential hypertension in the population of Tatars from Russia

Timasheva, Yanina; Nasibullin, T. R.; Имаева, Э. Б.; Erdman, V. V.; Tuktarova, I. A.; Мустафина, О. Е.

doi:10.1097/hjh.0000000000001332

Cited by 6 publications

(3 citation statements)

References 36 publications

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“…In Korean population, VEGF-2578C>A and -1154G>A polymorphisms have a protective effect on hypertension susceptibility [22]. VEGFA 2549 (18) I/D and VCAM1 rs3917010 were associated with SBP and DBP in Russian Tatars [23]. Observational data from a large number of participants showed that VEGF-1154G/A polymorphism can prevent hypertension [22,24].…”

Section: Discussionmentioning

confidence: 99%

Association of polymorphisms in endothelial dysfunction-related genes with susceptibility to essential hypertension in elderly Han population in Liaoning province, China

Ta¹,

Liu²,

Wang³

et al. 2021

Rev. Cardiovasc. Med.

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Hypertension is a complex disease which is mainly influenced by genetic factors. Recently, genome-wide association study (GWAS) found three novel endothelial dysfunction-related sites: Vascular endothelial growth factor A (VEGFA) rs9472135, Faciogenital dysplasia 5 (FGD5) rs11128722, Zinc Finger C3HC-type Containing 1 (ZC3HC1) rs11556924. Endothelial dysfunction is one of the early events in pathophysiology of essential hypertension. To investigate the association of endothelial dysfunction-related genes with essential hypertension, we conducted a case-control study of 431 patients with hypertension and 345 controls. The polymorphisms were detected using Taqman Probe. The alleles and genotypes of ZC3HC1 rs11556924 and VEGFA rs9472135 were not statistically different between the two groups, while the allele of FGD5 rs11128722 was different [P = 0.045, OR = 1.265, 95% CI = (1.009-1.586)], especially in the male [P = 0.035, OR = 1.496, 95% CI = (1.037-2.158)]. Analyzing the different of genotype distribution of 3 SNPs in the two groups under different genetic models, the genotypes of FGD5 rs11128722 showed difference in male under dominant model [P = 0.049, OR = 1.610, 95% CI = (1.018-2.544)]. The polymorphism of FGD5 rs11128722 had a significant difference in Body Mass Index (BMI) among different genotypes; In the additive genetic model, BMI of GA genotype was higher than that of GG (P = 0.038); GA + AA was higher than GG in the dominant genetic model (P = 0.011). In our study, we found that the polymorphisms of VEGFA rs9472135 and ZC3HC1 rs11556924 may not significantly associated with the risk of essential hypertension, and FGD5 rs11128722 may increase the risk of it, especially in elderly men.

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Section: Discussionmentioning

confidence: 99%

Association of polymorphisms in endothelial dysfunction-related genes with susceptibility to essential hypertension in elderly Han population in Liaoning province, China

Ta¹,

Liu²,

Wang³

et al. 2021

Rev. Cardiovasc. Med.

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“…As a major risk factor for cardiovascular and cerebrovascular diseases, essential hypertension (EH) is the top cause of death worldwide. 1,2 EH is commonly described as a complex disease indicated by a chronic elevation of blood pressure (BP) with no clear cause. It is a classic example of a multifactorial trait caused by the inheritance of susceptibility genes and multiple environmental factors.…”

Section: Introductionmentioning

confidence: 99%

“…It is a classic example of a multifactorial trait caused by the inheritance of susceptibility genes and multiple environmental factors. 1,3 Efforts to identify the genes responsible for the occurrence and development of EH are useful for understanding the genetic and pathogenic mechanisms behind it. However, genetic contributions are difficult to elucidate for EH.…”

Section: Introductionmentioning

confidence: 99%

Genetic association study of prolylcarboxypeptidase polymorphisms with susceptibility to essential hypertension in the Yi minority of China: A case–control study based on an isolated population

Yang

Xiao

2020

J Renin Angiotensin Aldosterone Syst

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Objective: Prolylcarboxypeptidase (PRCP) is a negative regulator of the pressor actions of the renin–angiotensin–aldosterone system. It is also involved in the kallikrein–kinin system. This gene has an important role in blood pressure (BP) regulation. Methods: A case–control study was performed for 615 Yi participants (303 cases and 312 controls) from a remote mountainous area in Yunnan Province of China. For the PRCP gene, 11 tag single-nucleotide polymorphisms were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. Results: The PRCP gene rs12290550 was associated with the occurrence of essential hypertension (EH) and BP traits. Logistic regression analysis indicated that the rs12290550 T allele was significantly linked to the risk of EH (odds ratio (OR) = 1.85, 95% confidence interval (CI) 1.44–2.39, p = 0.2 × 10−5). Under Bonferroni correction, the H7 TAGCACTAACA haplotype containing the risk allele rs12290550 T increased the risk of EH (OR = 4.53, 95% CI 2.29–8.93, p = 0.2×10−5). Conclusions: The findings of this study demonstrate the strong association of the PRCP gene with EH. rs12290550 may be a useful genetic predictor of EH in the Yi minority.

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Single nucleotide polymorphism-based biomarker in primary hypertension

Laxmi,

Golmei,

Srivastava

et al. 2024

European Journal of Pharmacology

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Genetic determinants of essential hypertension in the population of Tatars from Russia

Abstract: Our results suggest that rs5351 single-nucleotide polymorphism is a strong independent predictor of essential hypertension in men of Tatar ethnic origin.

Cited by 6 publications

References 36 publications

Association of polymorphisms in endothelial dysfunction-related genes with susceptibility to essential hypertension in elderly Han population in Liaoning province, China

Association of polymorphisms in endothelial dysfunction-related genes with susceptibility to essential hypertension in elderly Han population in Liaoning province, China

Genetic association study of prolylcarboxypeptidase polymorphisms with susceptibility to essential hypertension in the Yi minority of China: A case–control study based on an isolated population

Single nucleotide polymorphism-based biomarker in primary hypertension

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