Genetic determinants of radiation response. Report on a symposium held at Peter MacCallum Cancer Institute, Melbourne, Australia, 8 August 1996

This review article provides a comprehensive overview of the experimental data detailing the incidence, mechanism and significance of low dose hyper-radiosensitivity (HRS). Important discoveries gained from past and present studies are mapped and highlighted to illustrate the pathway to our current understanding of HRS and the impact of HRS on the cellular response to radiation in mammalian cells. Particular attention is paid to the balance of evidence suggesting a role for DNA repair processes in the response, evidence suggesting a role for the cell cycle checkpoint processes, and evidence investigating the clinical implications/relevance of the effect.

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Genetic determinants of radiation response. Report on a symposium held at Peter MacCallum Cancer Institute, Melbourne, Australia, 8 August 1996

Cited by 7 publications

References 0 publications

Expression of RAD51, BRCA1 and P53 does not correlate with cellular radiosensitivity of normal human fibroblasts

Expression of RAD51, BRCA1 and P53 does not correlate with cellular radiosensitivity of normal human fibroblasts

Exposure to low dose ionising radiation: Molecular and clinical consequences

Exposure to low dose ionising radiation: Molecular and clinical consequences

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