Genetic differences in cocaine-induced conditioned place preference in mice depend on conditioning trial duration

Cunningham, Christopher L.; Dickinson, Shelly D.; Grahame, Nicholas J.; Okorn, Dobrina M.; McMullin, Carrie S.

doi:10.1007/s002130051090

Cited by 67 publications

(55 citation statements)

References 41 publications

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“…CPP allows for such rapid screening. Indeed, Cunningham and colleagues have developed what appears to be a sensitive and optimally controlled CPP methodology for use in different mouse strains (Cunningham 1995;Cunningham et al 1999).…”

Section: What Are the Advantages Of Cpp?mentioning

confidence: 99%

“…Inherent differences in preference also pose a considerable obstacle for genetic analyses of CPP using inbred mouse strains, as strains may differ in the magnitude of inherent preference for one context, thus confounding the interpretation of shifts in preference following drug conditioning. Importantly, Cunningham et al (1999) have developed an exemplar nonbiased procedure utilizing tactile cues to assess CPP across different mouse strains.…”

Section: What Are the Limitations Of Cpp?mentioning

confidence: 99%

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Conditioned place preference: what does it add to our preclinical understanding of drug reward?

2000

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Rationale: Among the various experimental protocols that have been used to measure drug reward in laboratory animals, conditioned place preference (CPP) has been one of the most popular. However, a number of controversial issues have surrounded the use of this experimental protocol. Objective: The present review provides a theoretical overview of some critical issues relevant to CPP. The advantages and limitations of CPP are also covered. Results: Based on modern and traditional theoretical formulations of Pavlovian conditioning, CPP appears to refl ect a preference for a context due to the contiguous association between the context and a drug stimulus. Within this theoretical framework, it seems clear that CPP measures a learning process that is fundamentally distinct from drug self-administration. The main advantages of CPP are that it: (1) tests animals in a drugfree state; (2) is sensitive to both reward and aversion; (3) allows for simultaneous determination of CPP and locomotor activity; (4) is adaptable to a variety of species; (5) typically yields dose-effect curves that are monophasic rather than biphasic; and (6) has utility in probing the neural circuits involved in drug reward. The main limitations of CPP are that it: (1) is subject to interpretation based on the notion of novelty seeking; (2) is cumbersome for providing the graded dose-effect curves needed for answering some pharmacological questions; (3) is diffi cult to interpret when animals prefer one context prior to drug conditioning; and (4) lacks face validity as an experimental protocol of drug reward in humans. Conclusion: Despite some limitations, CPP provides unique information about the rewarding effect of contextual cues associated with a drug stimulus.

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Section: What Are the Advantages Of Cpp?mentioning

confidence: 99%

Section: What Are the Limitations Of Cpp?mentioning

confidence: 99%

Conditioned place preference: what does it add to our preclinical understanding of drug reward?

2000

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“…Place-conditioning procedures were conducted, as previously described (Cunningham, 1995;Cunningham et al, 1999;Bechtholt et al, 2004;Smith et al, 2014). Specifically, animals were randomly assigned to GRID 1 or GRID 2 conditioning groups, with genotype (WT, GlyT1…”

Section: /2mentioning

confidence: 99%

Availability of N-Methyl-d-Aspartate Receptor Coagonists Affects Cocaine-Induced Conditioned Place Preference and Locomotor Sensitization: Implications for Comorbid Schizophrenia and Substance Abuse

Puhl

Berg

Bechtholt

et al. 2015

J Pharmacol Exp Ther

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Schizophrenia is associated with high prevalence of substance abuse. Recent research suggests that dysregulation of N-methyl-D-aspartate receptor (NMDAR) function may play a role in the pathophysiology of both schizophrenia and drug addiction, and thus, may account for this high comorbidity. Our laboratory has developed two transgenic mouse lines that exhibit contrasting NMDAR activity based on the availability of the glycine modulatory site (GMS) agonists D-serine and glycine. Glycine transporter 1 knockdowns (GlyT1 1/2 ) exhibit NMDAR hyperfunction, whereas serine racemase knockouts (SR 2/2 ) exhibit NMDAR hypofunction. We characterized the behavior of these lines in a cocaine-induced (20 mg/kg) conditioned place preference (CPP) and locomotor sensitization paradigm. Compared with wild-type mice, GlyT1 1/2 mice displayed hastened extinction of CPP and robust cocaineinduced reinstatement. SR 2/2 mice appeared to immediately "forget" the learned preference, because they did not exhibit cocaine-induced reinstatement and also displayed attenuated locomotor sensitization. Treatment of GlyT1 1/2 mice with gavestinel (10 mg/kg on day 1; 5 mg/kg on days 2-17), a GMS antagonist, attenuated cocaine-induced CPP and caused them to immediately "forget" the learned preference. Treatment of SR 2/2 mice with D-serine (300 mg/kg on day 1; 150 mg/kg on days 2-17) to normalize brain levels caused them to avoid the cocaine-paired side of the chamber during extinction. These results highlight NMDAR dysfunction as a possible neural mechanism underlying comorbid schizophrenia and substance abuse. Also, these findings suggest drugs that directly or indirectly activate the NMDAR GMS could be an effective treatment of cocaine abuse.

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“…Extending this procedure to mice would allow systematic investigation of genetically altered mice that are purported to have depression-like profi les (see Cryan et al, 2002 for a recent review). To do so, will require careful development of a place conditioning protocol that does not include biases that vary across strains (Cunningham et al, 1999;see Cunningham et al, 2003 for a thorough discussion of bias in place conditioning studies). Similar to other functional assays with transgenic mice, any defi cit in novelty place conditioning will require detailed empirical work that assesses non-specifi c alterations in perceptual, motor, and learning abilities before concluding that decreased sensitivity to reward is responsible for blockade.…”

Section: Future Extensionsmentioning

confidence: 99%

Novelty reward as a measure of anhedonia

Bevins

Besheer

2005

Neuroscience & Biobehavioral Reviews

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Genetic differences in cocaine-induced conditioned place preference in mice depend on conditioning trial duration

Cited by 67 publications

References 41 publications

Conditioned place preference: what does it add to our preclinical understanding of drug reward?

Conditioned place preference: what does it add to our preclinical understanding of drug reward?

Availability of N-Methyl-d-Aspartate Receptor Coagonists Affects Cocaine-Induced Conditioned Place Preference and Locomotor Sensitization: Implications for Comorbid Schizophrenia and Substance Abuse

Novelty reward as a measure of anhedonia

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