Genetic differences in natural antibody levels in common carp (Cyprinus carpio L.)

Kachamakova, N.; Irnazarow, Ilgiz; Parmentier, H.K.; Savelkoul, H.F.J.; Pilarczyk, A.; Wiegertjes, G.F.

doi:10.1016/j.fsi.2006.01.005

Cited by 47 publications

(29 citation statements)

References 21 publications

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“…Baumgarth et al [202] suggest that, at a minimum, natural antibodies are redundant in these types of processes under non-stress conditions. In general, environmental conditions are considered important for the levels of natural antibodies in animals [215]. It is thought that the natural antibody repertoire and levels may be either shaped by continuous polyclonal stimulation by exogenous microbes, initiating cross reactivity driven responses of auto-reactive B cells, or corresponds with the secretion of naturally occurring auto-reactive B cell clones or both [216].…”

Section: Natural Antibodiesmentioning

confidence: 99%

“…It is thought that the natural antibody repertoire and levels may be either shaped by continuous polyclonal stimulation by exogenous microbes, initiating cross reactivity driven responses of auto-reactive B cells, or corresponds with the secretion of naturally occurring auto-reactive B cell clones or both [216]. The fact that Kachamakova et al [215] found higher levels of natural antibodies in pond-raised carp led them to suggest that this may point to an effect of exogenous stimuli on fish natural antibody levels.…”

Section: Natural Antibodiesmentioning

confidence: 99%

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The innate immune response of finfish – A review of current knowledge

Whyte

2007

Fish & Shellfish Immunology

529

284

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Section: Natural Antibodiesmentioning

confidence: 99%

Section: Natural Antibodiesmentioning

confidence: 99%

The innate immune response of finfish – A review of current knowledge

Whyte

2007

Fish & Shellfish Immunology

529

284

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“…Levels of Nab are affected by contact with non-pathogenic microbes, food, intestinal flora, and self-antigens (Quintana & Cohen 2004). The levels of Nab also depend on environmental factors (Kachamakova et al 2006), genetic background Pozsonyi et al 2009;Sun et al 2011), and age (Berghof et al 2010). Many Nab bind pathogen-associated molecular patterns (PAMP), e.g.…”

Section: Introductionmentioning

confidence: 99%

Natural (auto)antibodies in calves are affected by age and diet

Khobondo

Nieuwland

Webb

et al. 2015

Veterinary Quarterly

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Background: Natural autoantibodies (N(a)ab) were found in every species tested so far, and are likely important in maintaining homeostasis. Objectives: (1) To determine N(a)ab in Bos taurus calves, (2) evaluate effects of diet and age on N(a)ab binding repertoires in calves, and (3) delineate bovine liver cell lysate (BLL) antigens related with variation in rumen score and body weight. Animals and methods: Effects of age and diet on staining of BLL fragments by IgM and IgG antibodies in serum samples collected at 20 or at 26 weeks of age from bull calves either fed a restricted or ad libitum diet were analyzed using quantitative Western blotting. Correlations between fragments stained and grouping of calves were done by Principal Component Analysis (PCA). Redundancy analysis (RDA) was done to relate rumen score and body weight variation at slaughter at 27 weeks of age with stained BLL fragments. Results: In sera from all calves IgM and IgG antibodies binding BLL antigens were found. Corresponding fragments were stained, but quantitative differences in staining intensities were related to diet and age for both IgM and IgG. PCA revealed that age had a greater influence than diet on BLL fragment staining. RDA suggested that staining by IgM or IgG of specific BLL fragments was related with variation in rumen score and body weight. Conclusions and clinical importance: Analyses of N(a)ab in serum could be a potential tool to estimate the health status of cattle, and be used to evaluate effects of husbandry practices.

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“…[40][41][42] There is also convincing evidence for parent-offspring effects and genetic heritability in human serum IgM levels [37][38][39] as well as evidence for genetic control of natural IgM titers in mammals, 43 birds 44 and fish. 45 However, no linkage evidence for quantitative trait loci influencing serum IgM has been reported and the genetics of the homeostatic regulation of serum IgM remains largely unknown. Here, we characterized a total IgM serum phenotype in mouse inbred strains and performed a genome-wide screen that identified a region on mouse chromosome 13 that contained a locus (loci) controlling IgM serum levels.…”

Section: Introductionmentioning

confidence: 99%

Irf4 is a positional and functional candidate gene for the control of serum IgM levels in the mouse

et al. 2008

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Natural IgM are involved in numerous immunological functions but the genetic factors that control the homeostasis of its secretion and upholding remain unknown. Prompted by the finding that C57BL/6 mice had significantly lower serum levels of IgM when compared with BALB/c mice, we performed a genome-wide screen and found that the level of serum IgM was controlled by a QTL on chromosome 13 reaching the highest level of association at marker D13Mit266 (LOD score¼3.54). This locus was named IgMSC1 and covered a region encompassing the interferon-regulatory factor 4 gene (Irf4). The number of splenic mature B cells in C57BL/6 did not differ from BALB/c mice but we found that low serum levels of IgM in C57BL/6 mice correlated with lower frequency of IgM-secreting cells in the spleen and in the peritoneal cavity. These results suggested that C57BL/6 mice have lower efficiency in late B-cell maturation, a process that is highly impaired in Irf4 knockout mice. In fact, we also found reduced Irf4 gene expression in B cells of C57BL/6 mice. Thus, we propose Irf4 as a candidate for the IgMSC1 locus, which controls IgM homeostatic levels at the level of B-cell terminal differentiation

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Genetic differences in natural antibody levels in common carp (Cyprinus carpio L.)

Cited by 47 publications

References 21 publications

The innate immune response of finfish – A review of current knowledge

The innate immune response of finfish – A review of current knowledge

Natural (auto)antibodies in calves are affected by age and diet

Irf4 is a positional and functional candidate gene for the control of serum IgM levels in the mouse

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