Genetic differentiation and phylogeny of 27 sheep populations based on structural gene loci

Li, Mingxun; Xia, Hailei; Chen, Dan; Ji, Dejun; Tsunoda, Kenji; Li, Rui; Liao, Xiangxiang; Mao, Yongjiang; Sun, Weibang; Geng, Rong; Yang, Zhangping

doi:10.1016/j.mcp.2017.11.006

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…Numerous studies indicate that the MSRB3 gene is also a candidate gene associated with ear size in sheep (Wei et al, 2015), pigs (Zhang et al, 2014), and dog (Boyko et al, 2010). Altay sheep, belonging to the Kazak lineage, inhabit the Altay area (Xinjiang, China) where the winter is long and cold (Li et al, 2018). In this harsh environment, the short-tailed phenotypes of Altay sheep store large amounts of fat on their buttocks as overwinter reserves (Pourlis, 2011).…”

Section: Resultsmentioning

confidence: 99%

Deep Genome Resequencing Reveals Artificial and Natural Selection for Visual Deterioration, Plateau Adaptability and High Prolificacy in Chinese Domestic Sheep

et al. 2019

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Sheep were one of the earliest domesticated animals. Both artificial and natural selection during domestication has resulted in remarkable changes in behavioral, physiological, and morphological phenotypes; however, the genetic mechanisms underpinning these changes remain unclear, particularly for indigenous Chinese sheep. In the present study, we performed pooled whole-genome resequencing of 338 sheep from five breeds representative of indigenous Chinese breeds and compared them to the wild ancestors of domestic sheep (Asian mouflon, Ovis orientalis ) for detection of genome-wide selective sweeps. Comparative genomic analysis between domestic sheep and Asian mouflon showed that selected regions were enriched for genes involved in bone morphogenesis, growth regulation, and embryonic and neural development in domestic sheep. Moreover, we identified several vision-associated genes with funtional mutations, such as PDE6B (c.G2994C/p.A982P and c.C2284A/p.L762M mutations), PANK2 , and FOXC1/GMSD in all five Chinese native breeds. Breed-specific selected regions were determined including genes such as CYP17 for hypoxia adaptability in Tibetan sheep and DNAJB5 for heat tolerance in Duolang sheep. Our findings provide insights into the genetic mechanisms underlying important phenotypic changes that have occurred during sheep domestication and subsequent selection.

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Section: Resultsmentioning

confidence: 99%

Deep Genome Resequencing Reveals Artificial and Natural Selection for Visual Deterioration, Plateau Adaptability and High Prolificacy in Chinese Domestic Sheep

et al. 2019

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“…As early domesticated animals, sheep provide meat, milk, and other products for humans (Awawdeh, 2011;Li et al, 2018). Hu sheep originated in the Taihu region and is one of the local breeds in China.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphism of the ovine MAP3K5 gene and its association with body size traits in Hu sheep of China

et al. 2023

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Abstract. As an excellent local sheep breed in China, Hu sheep have the characteristics of producing more lambs and good motherhood. The purpose of this study was to identify the polymorphism of the mitogen-activated protein kinase 5 (MAP3K5) gene and determine whether it was associated with the body size traits (body height, body length, chest circumference, and cannon circumference) in Hu sheep. The polymorphism of MAP3K5 was identified by using PCR amplification, followed by Sanger sequencing, and KASPar (Kompetitive Allele Specific PCR) technology was used for genotyping subsequently. The results of the association analysis showed that MAP3K5 (g.205261 A > G) was significantly associated with body height at 80, 100, 140, 160, and 180 d; body length at 80 and 160 d; chest circumference at 100, 140, 160, and 180 d; and cannon circumference at 100 and 120 d, respectively. The results of qRT-PCR showed that the expression level of MAP3K5 in the heart was significantly higher (P < 0.05) than in the other 10 tissues. In summary, the MAP3K5 mutation loci may be used as a candidate molecular marker for the body size traits of Hu sheep.

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Genomic insights into demographic history, structural variation landscape, and complex traits from 514 Hu sheep genomes

Chen,

Zhang,

Pan

et al. 2024

Journal of Genetics and Genomics

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Genetic differentiation and phylogeny of 27 sheep populations based on structural gene loci

Cited by 3 publications

References 10 publications

Deep Genome Resequencing Reveals Artificial and Natural Selection for Visual Deterioration, Plateau Adaptability and High Prolificacy in Chinese Domestic Sheep

Deep Genome Resequencing Reveals Artificial and Natural Selection for Visual Deterioration, Plateau Adaptability and High Prolificacy in Chinese Domestic Sheep

Genetic polymorphism of the ovine MAP3K5 gene and its association with body size traits in Hu sheep of China

Genomic insights into demographic history, structural variation landscape, and complex traits from 514 Hu sheep genomes

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