Genetic Diversity and Histo-Blood Group Antigen Interactions of Rhesus Enteric Caliciviruses

Farkas, Tibor; Cross, Robert W.; Hargitt, Edwin; Lerche, Nicholas W.; Morrow, Ardythe L.; Sestak, Karol

doi:10.1128/jvi.00630-10

Cited by 120 publications

(150 citation statements)

References 45 publications

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“…Cell culture studies with TV also demonstrated that type A and B, but not type O boiled saliva samples block TV replication in vitro, most likely by blocking attachment of the virus to cell surface ligands (Farkas et al, 2010a). Evaluation of G1 ReCVs with a panel (n535) of human saliva samples revealed the existence of three HBGA interaction types (unpublished data) (Fig.…”

Section: Recv-hbga Interactionsmentioning

confidence: 99%

“…An association between ReCV infections and particular HBGA type(s) could not be established by the assessment of 500 colony macaques because 98 % of the animals phenotyped as type B (Farkas et al, 2010a). ReCV challenge studies to correlate in vitro HBGA binding to susceptibility to infection still remain to be performed.…”

Section: Recv-hbga Interactionsmentioning

confidence: 99%

“…Moreover, the G1 strains further separated into three genotypes (G1.1-G1.3) (Farkas et al, 2010a) (Fig. 1a).…”

Section: Genetic Diversitymentioning

confidence: 99%

“…Although ReCVs represent a novel genus within the family Caliciviridae, their epidemiology, biological features, disease spectrum and natural host are more closely related to those of human NoVs than any of the other surrogate viruses. In addition, the role of ReCVs as human pathogens has also been indicated (Farkas & Wong Pin Lun, 2014;Farkas et al, 2010a;Smits et al, 2012). The aim of this review is to summarize our current knowledge about ReCVs, highlight their biological similarities to human NoVs and discuss applications of the model in addressing questions relevant for human NoV research.…”

Section: Introductionmentioning

confidence: 99%

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Rhesus enteric calicivirus surrogate model for human norovirus gastroenteritis

Farkas

2015

Journal of General Virology

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Human noroviruses are one of the major causes of acute gastroenteritis worldwide. Due to the lack of an efficient human norovirus cell culture system coupled with an animal model, human norovirus research mainly relies on human volunteer studies and surrogate models. Current models either utilize human norovirus-infected animals including the gnotobiotic pig or calf and the chimpanzee models, or employ other members of the family Caliciviridae including cell culture propagable surrogate caliciviruses such as the feline calicivirus, murine norovirus and most recently the Tulane virus. One of the major features of human noroviruses is their extreme biological diversity, including genetic, antigenic and histo-blood group antigen binding diversity, and possible differences of virulence and environmental stability. This extreme biological diversity and its effect on intervention/prevention strategies cannot be modelled by uniform groups of surrogates, much less by single isolates. Tulane virus, the prototype recovirus strain, was discovered in 2008. Since then, several other novel recoviruses have been described and cell culture adapted. Recent studies indicate that the epidemiology, the biological features and diversity of recoviruses and the course of infection and clinical disease in recovirus-infected macaques more closely reflect those properties of human noroviruses than any of the current surrogates. This review aims to summarize what is currently known about recoviruses, highlight their biological similarities to human noroviruses and discuss applications of the model in addressing questions relevant for human norovirus research.

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Section: Recv-hbga Interactionsmentioning

confidence: 99%

Section: Recv-hbga Interactionsmentioning

confidence: 99%

“…Moreover, the G1 strains further separated into three genotypes (G1.1-G1.3) (Farkas et al, 2010a) (Fig. 1a).…”

Section: Genetic Diversitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Rhesus enteric calicivirus surrogate model for human norovirus gastroenteritis

Farkas

2015

Journal of General Virology

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“…98 Recently, the use of the Tulane virus (TV), a recovirus strain (ReCV), isolated from the stool of rhesus macaques 116 has been advanced as a possible surrogate model for human NoV gastroenteritis. Anti-NoV and anti-TV neutralizing antibodies have been reported in macaques; 117 moreover, TV-neutralizing antibodies were detected in sera of primate caretakers 118 as well as the general population yet at lower levels. 119 The role of HBGA was also tested in TV infection whereby type A and type B were found to be involved in the latter.…”

Section: Animal Studiesmentioning

confidence: 99%

Norovirus vaccines: Correlates of protection, challenges and limitations

Melhem

2016

Human Vaccines & Immunotherapeutics

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Norovirus (NoV) is responsible for at least 50% of all gastroenteritis outbreaks worldwide. NoVs are classified into 6 different genogroups (GGI-GGVI) based on the viral capsid protein with NoV genogroup II genotype 4 (GII.4) being the predominant strain causing human diseases. Supportive therapy involving reversal of dehydration and electrolyte deficiency is the main treatment of NoV gastroenteritis. However, the worldwide increased recognition of NoV as an important agent of diarrheal gastroenteritis prompted researchers to focus on establishing preventive strategies conferring long-lasting immunity. This review describes the current status of animal and human vaccine models/studies targeting NoV and addresses the factors hampering the development of a broadly effective vaccine.

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Familial aggregation of chronic diarrhea disease (CDD) in rhesus macaques (Macaca mulatta)

Kanthaswamy

Elfenbein

Ardeshir

et al. 2013

American J Primatol

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Chronic diarrheal disease (CDD) is a critical problem for breeders of captive rhesus macaque (Macaca mulatta), as it results in significant levels of morbidity and death annually. As with other inflammatory disorders, CDD is thought to be caused by environmental and/or genetic factors. Although correspondence between the characters defined as Mendelian by pedigree or segregation analysis and functional genes is difficult to establish, such analyses provide essential entry points into understanding CDD in captive bred rhesus macaques. To investigate the familial aggregation of CDD in captive rhesus macaque, we performed pedigree, segregation and heritability analyses on genealogical data from 55 severely affected individuals (probands) through whom relatives with a history of CDD were ascertained from routine computerized colony records comprising vital and demographic statistics of 10,814 rhesus macaques. We identified 175 rhesus macaques with CDD and estimated its incidence as approximately 2% in the colony. The disease strongly clustered in eight multi-generation pedigrees. Inspection of the pedigrees, segregation analysis and heritability estimate of CDD suggest that susceptibility to the disease is under strong genetic control. Identification of the locations of susceptibility genes in the rhesus macaque genome could facilitate the reduction of their frequency in captive breeding facilities.

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Genetic Diversity and Histo-Blood Group Antigen Interactions of Rhesus Enteric Caliciviruses

Cited by 120 publications

References 45 publications

Rhesus enteric calicivirus surrogate model for human norovirus gastroenteritis

Rhesus enteric calicivirus surrogate model for human norovirus gastroenteritis

Norovirus vaccines: Correlates of protection, challenges and limitations

Familial aggregation of chronic diarrhea disease (CDD) in rhesus macaques (Macaca mulatta)

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