2020
DOI: 10.1134/s0026893320010136
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Genetic Diversity in Frontotemporal Dementia

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Cited by 12 publications
(6 citation statements)
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“…BvFTD was the most common clinical variant followed by language variants ( 35 , 36 ). Regarding distribution by sex and the incidence of disease, there was no significant difference between the clinical groups ( 11 , 26 , 31 ). All the SNPs associated with FTD reached HW equilibrium in our population.…”
Section: Discussionmentioning
confidence: 81%
See 1 more Smart Citation
“…BvFTD was the most common clinical variant followed by language variants ( 35 , 36 ). Regarding distribution by sex and the incidence of disease, there was no significant difference between the clinical groups ( 11 , 26 , 31 ). All the SNPs associated with FTD reached HW equilibrium in our population.…”
Section: Discussionmentioning
confidence: 81%
“…No sex differences were found in the total sample or inside each clinical variant (see Table 2 ). As for the patient's education level, only 8.5% ( 9 ) had primary education, 19.2% ( 28 ) completed secondary education, and 35.6% ( 31 ) had undertaken university studies. It was not possible to determine the education level of 38 patients.…”
Section: Resultsmentioning
confidence: 99%
“…Frontotemporal dementia (FTD) is the second most common cause of early dementia after AD, manifesting itself before the age of 65 (Olney et al, 2017). Frontotemporal dementia has both sporadic forms and genetically determined causes since about 40% of cases have a family origin (Shpilyukova et al, 2020). FTD is characterized by the deposition of abnormal DNA-binding protein 43 (TDP-43) or tau protein aggregates in the frontal and temporal lobes of the brain, resulting in neuronal degeneration, behavioral abnormalities, or language dysfunction with progressive degeneration of the frontal and temporal lobes.…”
Section: Frontotemporal Dementiamentioning
confidence: 99%
“…FTD is marked by significant frontal and temporal lobe atrophy, typically containing abnormal tau or ubiquitin protein inclusions. It primarily represents a sporadic condition, although genetics play a significant role in approximately 40% of cases having a familial origin [26] and a quarter of cases showing autosomal dominant inheritance. Key genes implicated in FTD pathogenesis include genes coding for microtubule-associated protein (MAPT), granulin (GRN), and chromosome 9 open reading frame 72 (C9ORF72) [27][28][29].…”
Section: Dementiamentioning
confidence: 99%