Genetic diversity of growth hormone receptor gene in cattle

Lin, Bang Zhong; Sasazaki, Shinji; Lee, June Heon; Mannen, Hideyuki

doi:10.1111/j.1740-0929.2009.00676.x

Cited by 5 publications

(4 citation statements)

References 19 publications

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“…Gen bovine growth hormone receptor (bGHR) disandikan sebagai gen tunggal dan terletak pada kromosom 20 (Lin et al, 2009). Single nucleotide polymorphism (SNP) ditemukan pada ekson 10 pada posisi 257 pb (A/G) yang mengubah susunan asam amino serina menjadi glisina (Ge et al, 2000).…”

Section: Pendahuluanunclassified

Identifikasi Keragaman Genetik Gen Reseptor Hormon Pertumbuhan (GHR|Alu I) pada Sapi Bali

Zulkharnaim¹,

Zakaria²,

Noor³

2010

medpet

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Section: Pendahuluanunclassified

Identifikasi Keragaman Genetik Gen Reseptor Hormon Pertumbuhan (GHR|Alu I) pada Sapi Bali

Zulkharnaim¹,

Zakaria²,

Noor³

2010

medpet

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“…Several polymorphisms have been detected in PPARGC1A gene, and significant relationships between SNPs of this gene and carcass weight have been reported in Hanwoo cattle [ 10 , 12 , 41 , 90 ]. GHR (growth hormone receptor) is located on chromosome 20 in cattle and consists of 10 exons and nine introns [ 91 , 92 ], and it has been considered as a candidate gene for meat quality and growth traits [ 93 , 94 ]. GHR is a member of the class I cytokine receptor family and is bound by growth hormone (GH), leading to the activation of hormonal systems involved in growth development [ 95 ].…”

Section: Candidate Genes Affecting Carcass Weightmentioning

confidence: 99%

Exploring and Identifying Candidate Genes and Genomic Regions Related to Economically Important Traits in Hanwoo Cattle

Naserkheil

Manzari

Dang

et al. 2022

CIMB

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The purpose of the current review was to explore and summarize different studies concerning the detection and characterization of candidate genes and genomic regions associated with economically important traits in Hanwoo beef cattle. Hanwoo cattle, the indigenous premium beef cattle of Korea, were introduced for their marbled fat, tenderness, characteristic flavor, and juiciness. To date, there has been a strong emphasis on the genetic improvement of meat quality and yields, such as backfat thickness (BFT), marbling score (MS), carcass weight (CW), eye muscle area (EMA), and yearling weight (YW), as major selection criteria in Hanwoo breeding programs. Hence, an understanding of the genetics controlling these traits along with precise knowledge of the biological mechanisms underlying the traits would increase the ability of the industry to improve cattle to better meet consumer demands. With the development of high-throughput genotyping, genomewide association studies (GWAS) have allowed the detection of chromosomal regions and candidate genes linked to phenotypes of interest. This is an effective and useful tool for accelerating the efficiency of animal breeding and selection. The GWAS results obtained from the literature review showed that most positional genes associated with carcass and growth traits in Hanwoo are located on chromosomes 6 and 14, among which LCORL, NCAPG, PPARGC1A, ABCG2, FAM110B, FABP4, DGAT1, PLAG1, and TOX are well known. In conclusion, this review study attempted to provide comprehensive information on the identified candidate genes associated with the studied traits and genes enriched in the functional terms and pathways that could serve as a valuable resource for future research in Hanwoo breeding programs.

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“…The frequency of S allele of GHR was relatively high in JBK, but rare in European breeds (Lin et al . ). Moreover, subpopulation and/or strain differences in the allele frequencies of the GH, SCD and NCAPG genes have been reported (Otagaki et al .…”

Section: Introductionmentioning

confidence: 97%

Epistatic effects between pairs of the growth hormone secretagogue receptor 1a, growth hormone, growth hormone receptor, non‐SMC condensin I complex, subunit G and stearoyl‐CoA desaturase genes on carcass, price‐related and fatty acid composition traits in Japanese Black cattle

Komatsu

Nishino

Fujimori

et al. 2017

Animal Science Journal

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Growth hormone secretagogue receptor 1a (GHSR1a), growth hormone (GH), growth hormone receptor (GHR), non-SMC condensin I complex, subunit G (NCAPG) and stearoyl-CoA desaturase (SCD), are known to play important roles in growth and lipid metabolisms. Single and epistatic effects of the five genes on carcass, price-related and fatty acid (FA) composition traits were analyzed in a commercial Japanese Black cattle population of Ibaraki Prefecture. A total of 650 steers and 116 heifers for carcass and price-related traits, and 158 steers for FA composition traits were used in this study. Epistatic effects between pairs of the five genes were found in several traits. Alleles showing strain-specific differences in the five genes had significant single and epistatic effects in some traits. The data suggest that a TG-repeat polymorphism of the GHSR1a.5'UTR-(TG) locus plays a central role in gene-gene epistatic interaction of FA composition traits in the adipose tissue of Japanese Black cattle.

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Genetic diversity of growth hormone receptor gene in cattle

Cited by 5 publications

References 19 publications

Identifikasi Keragaman Genetik Gen Reseptor Hormon Pertumbuhan (GHR|Alu I) pada Sapi Bali

Identifikasi Keragaman Genetik Gen Reseptor Hormon Pertumbuhan (GHR|Alu I) pada Sapi Bali

Exploring and Identifying Candidate Genes and Genomic Regions Related to Economically Important Traits in Hanwoo Cattle

Epistatic effects between pairs of the growth hormone secretagogue receptor 1a, growth hormone, growth hormone receptor, non‐SMC condensin I complex, subunit G and stearoyl‐CoA desaturase genes on carcass, price‐related and fatty acid composition traits in Japanese Black cattle

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