Genetic diversity of hemoglobinopathies, G6PD deficiency, and ABO and Rhesus blood groups in two isolates of a primitive Kharia Tribe in Sundargarh District of Northwestern Orissa, India

Balgir, R. S.

doi:10.1007/s12687-010-0016-y

Cited by 11 publications

(12 citation statements)

References 8 publications

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“…Numerous studies were reported at the context of disease epidemiology and genetics, upon various indian tribal communities, who are highly isolated both demographically and topogra phically, from the mainstream indian populations [4][5][6][7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Association of ACE <i>DD</i> Genotype with Hypertension among the Tribal Populations of South India

Paramasivam

Nandakumar

Arumugam

et al. 2016

ILNS

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The Renin-Angiotensin System (RAS) is an important regulator of the blood pressure(BP). The level of the vasoactive peptide Angiotensin-II, is mainly determined by the RAS enzyme, angiotensin converting enzyme-1 (ACE-1). Polymorphisms in ACE gene is reported to be associated with hypertension in various populations worldwide. We investigated the association of ACE I/D polymorphisms with hypertension among the tribal populations of South India. Samples were collected from hypertensive patients (n = 33) and healthy controls (n = 37). Genotyping was performed using Polymerase chain reaction (PCR) with allele specific primers. The DD genotype is significantly observed among the cases (OR = 1.0) . Specifically, the DD genotype is more evident among the females (OR = 0.705) than males (OR = 1.22) and is analysed to be associated with hypertension among the tribal populations of South India.

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Section: Introductionmentioning

confidence: 99%

Association of ACE <i>DD</i> Genotype with Hypertension among the Tribal Populations of South India

Paramasivam

Nandakumar

Arumugam

et al. 2016

ILNS

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“…India is a large country with numerous ethnic groups wherin SCD is prevalent in numerous ethnic groups, in India. The high prevalence of sickle cell in several distinct groups in India has been the subject of extensive population based studies . Among the major ethnic groups with a high burden of SCD are autochthonous tribal peoples known as scheduled tribes or Adivasis.…”

Section: Introductionmentioning

confidence: 99%

“…The scheduled tribes consist of over 645 distinct ethnic groups consisting of over 84 million individuals representing 8% of India's population . Differences in ethnic origins, genetic background, and migration histories of these endogamous tribes, who serve as genetic isolates may explain the variation in the sickle cell trait carrier frequency of 10–33% in these populations . In many tribal communities, patients with SCD do not receive comprehensive care for SCD due to the lack of access to health care, socioeconomic deprivation, and geographical and cultural isolation.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive integrated care for patients with sickle cell disease in a remote aboriginal tribal population in southern India

Nimgaonkar

Krishnamurti

Prabhakar

et al. 2013

Pediatric Blood & Cancer

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“…Evidence for the strong selective effect of malaria resistance includes the high frequency of a number of detrimental hemato-genetic diseases (including the different hemoglobinopathies, thalassemias, and red cell enzymopathy), caused by the effects of these malaria resistance variants. In view of this pathetic scenario, it is justifiable that population genetics could be useful to determine the amount and pattern of natural selection in human population isolates [5][6][7][8][9][10][11][12].…”

Section: Cardinal Malaria Situationmentioning

confidence: 99%

Protective Resistance by Human G6PD Enzyme Deficiency and Hemoglobin Variants Against Malaria and Natural Selection: Further Evidence from Review of New Studies

ranbir

2019

EAST

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Main objective of this article is to review and evaluate recent red cell variant studies for protection against malaria and natural selection. Malaria is a parasitic disease highly widespread in tropical and subtropical regions of the world. It is also one of the leading causes of death worldwide and genes involved in malaria resistance are the most important for natural selection in human populations. Multiple red cell variants, which evolved probably to counter the lethal effects of malaria and confer protection against malaria through different mechanisms, show high frequencies in malaria endemic vulnerable populations. Different natural protective/resistance mechanisms including hampering of parasite growth, invasion related immunological responses or rapidly elimination of malaria parasite from the infected erythrocytes of host have briefly been discussed, evaluated, and reviewed. Conclusions drawn have been projected here. High frequency of inherited hemoglobin disorders including thalassemias, and red cell G6PD enzyme deficiency, which seemed to evolve simultaneously in relation to malaria, and high mortality caused by Plasmodium falciparum malaria in different vulnerable populations of tropical and subtropical parts of world, confirm that the natural selection is certainly operating against malaria in one way or another; and human population genetics have distinctly played a significant role in the co-evolution of host and malaria. The inverse relationship between sickle cell trait and G6PD deficiency and vice versa, revealed by allele frequencies distribution shown in our previous studies, is a testimony of disequilibrium, as sickle cell allele being replaced by G6PD deficiency allele in populations of central India. Positive natural selection plays a definite role against malaria for maintaining balance in high frequency endemic populations.

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Genetic diversity of hemoglobinopathies, G6PD deficiency, and ABO and Rhesus blood groups in two isolates of a primitive Kharia Tribe in Sundargarh District of Northwestern Orissa, India

Abstract: Tribal communities constitute about 8

Cited by 11 publications

References 8 publications

Association of ACE <i>DD</i> Genotype with Hypertension among the Tribal Populations of South India

Association of ACE <i>DD</i> Genotype with Hypertension among the Tribal Populations of South India

Comprehensive integrated care for patients with sickle cell disease in a remote aboriginal tribal population in southern India

Protective Resistance by Human G6PD Enzyme Deficiency and Hemoglobin Variants Against Malaria and Natural Selection: Further Evidence from Review of New Studies

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