The Renin-Angiotensin System (RAS) is an important regulator of the blood pressure(BP). The level of the vasoactive peptide Angiotensin-II, is mainly determined by the RAS enzyme, angiotensin converting enzyme-1 (ACE-1). Polymorphisms in ACE gene is reported to be associated with hypertension in various populations worldwide. We investigated the association of ACE I/D polymorphisms with hypertension among the tribal populations of South India. Samples were collected from hypertensive patients (n = 33) and healthy controls (n = 37). Genotyping was performed using Polymerase chain reaction (PCR) with allele specific primers. The DD genotype is significantly observed among the cases (OR = 1.0) . Specifically, the DD genotype is more evident among the females (OR = 0.705) than males (OR = 1.22) and is analysed to be associated with hypertension among the tribal populations of South India.

Northern India is one of the oldest geophysical regions of human evolution and migration in the world. Genetic and anthropological studies have shown that the peopling the subcontinent is characterized by a complex history, contributed from different ancestral populations. Genetic level studies of polymorphisms always associated with health and diseases of population becoming the need of hours. The present study was aimed to explore the relationship of ABO blood groups association of populations and to assess the prevalence of blood groups in different categories of Northern India and to compare our results with other studies conducted in India. Blood samples from 155 unrelated individuals was collected from Naga tribal settlements Blood groups of individuals were evaluated with the presence of antigen using monoclonal antibody by a standard blood typing are protocol, Gene frequencies was calculated by Hardy-Weinberg method. The blood group O 67 (43.23%) was the commonest group prevalent in donors followed by group B 45 (29.03%), A 33(21.29%) and AB 10 (6.45%). The Rh negative was not observed in female donors, whereas in male it was found to be 1.3%.Data among tribal suggest their common origin as well as a drift from an original population due to the possible founder effect among tribal Naga Ten Tribal

Urinary tract infections(UTI) are the most common problem caused by infections in the urinary system, which includes kidneys, bladder, ureters and urethra. Urinary infections are found to be one of the common diseases worldwide. The study mainly focuses on analyzing the association of TPA 25 gene with Urinary tract infected individual in tribal population of Dimapur District. This study considers the population of Urinary tract infection(UTI)patients. The samples of the study consist of 32 Urinary tract infected patient which was collected from Eden hospital, Dimapur and 32 control samples through random sampling technique. The genotyping is done using Polymerase Chain Reaction (PCR) with allele specific marker (TPA 25). The study concluded that the association of TPA gene is significantly high in both ID and DD genotype (0.00*) of the male population and females shows statistical significant in ID and II phenotype (0.002*).

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