Genetic diversity of the genus Lactobacillus bacteria from the human gastrointestinal microbiome

Ботина, С. Г.; Koroban, N. V.; Klimina, Ksenia M.; Glazova, A. A.; Zakharevich, Natalia V.; Зинченко, В.В.; Даниленко, В. Н.

doi:10.1134/s102279541012001x

Cited by 4 publications

(1 citation statement)

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“…According to definition of probiotic recommended by FAO/WHO, probiotics are live microorganisms, which when administered in adequate amounts confer a health benefit on the host (13). Bacterial species that are currently of commercial interest as probiotics mainly belong to the genus Lactobacillus and Bifidobacterium (8,20,33). Their use in the recommended doses is safe for humans.…”

Section: Introductionmentioning

confidence: 99%

Probiotic features of two oral Lactobacillus isolates

Zavišić¹,

Petricevic²,

Radulović³

et al. 2012

Braz. J. Microbiol.

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In this study, we checked lactobacilli strains of human origin for their potential as probiotic. Samples were collected from oral mucosa of 16 healthy individuals, out of which twenty isolates were obtained and two of them were selected and identified as Lactobacillus plantarum (G1) and L. casei (G3). Both isolates exhibited antagonistic action towards pathogenic microorganisms such as Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Salmonella abony, and Clostridium sporogenes, but not on the growth of Candida albicans. The bacteriocin activity against Staphylococcus aureus ATCC 6358-P was shown only by L. plantarum G1. Moreover, the isolates G1 and G3 showed good viability in the acid gastric environment and in the gut environment containing bovine bile salts. The viability of G1 and G3 isolates in the gastrointestinal tract, and the adhesion to the intestinal mucosa were also confirmed in vivo. The biochemical tests of blood samples revealed lower levels of serum triglycerides and cholesterol, as well as reduced activity of alkaline phosphatase in all lactobacilli-treated Wistar rats, compared to control ones. No toxicity for NMRI Ham mice was observed. According to our experimental results, these findings imply that L. plantarum G1 and L. casei G3 could be characterized as potential probiotics

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Section: Introductionmentioning

confidence: 99%