Genetic, Environmental, and Disease-Associated Correlates of Vitamin D Status in Children with CKD

Doyon, Anke; Schmiedchen, Bettina; Sander, Anja; Bayazıt, Aysun Karabay; Düzova, Ali; Canpolat, Nur; Thurn, Daniela; Ažukaitis, Karolis; Anarat, Ali; Bacchetta, Justine; Mır, Sevgı; Shroff, Rukshana; Candan, Cengiz; Kemper, Markus J.; Fischbach, Michel; Cortina, Gérard; Klaus, Günter; Wuttke, Matthias; Köttgen, Anna; Melk, Anette; Querfeld, Uwe; Schaefer, Franz

doi:10.2215/cjn.10210915

Cited by 12 publications

(2 citation statements)

References 43 publications

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“…As for vertebral BMD, RFs that explained up to 73% of variability were age, sex, hypovitaminosis D, and ethnicity. The positive effect of hypovitaminosis D could be a potential confounding effect associated with seasonal uctuations or solar exposition [14,15], included patient's ethnicity [16], genetic polymorphisms [14,15,17], or underlying diseases [15].…”

Section: Resultsmentioning

confidence: 99%

Bone Health in Children With Risk Factors for Low Bone Mass

Magallares

Cerdá

Betancourt

et al. 2022

Preprint

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Purpose: To describe clinical and biological characteristics of pediatric patients with at least one risk factor (RF) for low bone mass for chronological age (LBMca)/childhood osteoporosis (cOP) and to assess its influence on bone mineral density (BMD).Methods: Patients between 2 and 20 years of age with at least 1 RF were recruited. Daily calcium intake, number of previous fractures and other RFs and their distribution among different groups were assessed. Spine and whole body DXA and vertebral morphometry were performed.Results: 103 patients were included. Mean age was 9.8 years old. 52.4% were female. Of the RFs, 84.5% presented insufficient calcium intake, 38.8% were receiving or had received corticosteroids, 31.1% were receiving other treatments with osteotoxic potential, 13.6% led a sedentary lifestyle, 12.6% presented history of fractures, and up to 8.1% had hypovitaminosis D. 38% of the cohort had 2 RFs, 31% had 3 RFs, 15% had 4 RFs, and 12% associated 5 or more RFs. 10.5% met LBMca criteria and 4.8% met cOP criteria. 73% of vertebral BMD was justified by age and hypovitaminosis D (positive effect), and male sex and Hispanic ethnicity (negative effect). 82% of total body less head BMD was justified by age (positive effect), and Hispanic ethnicity and sedentary lifestyle (negative effect).Conclusions: Pediatric populations with risk of LBM/cOP have 2 or more risk factors. Up to 10.5% of children with RFs present LBM and 4.8% have an unknown cOP. RFs related to changes in BMD are age, sex, sedentary lifestyle, ethnicity, and hypovitaminosis D.

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Section: Resultsmentioning

confidence: 99%

Bone Health in Children With Risk Factors for Low Bone Mass

Magallares

Cerdá

Betancourt

et al. 2022

Preprint

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“…[1] Vitamin D insufficiency is commonly found in children with chronic kidney disease (CKD), and it relates to mineral and bone problems. [3][4] Furthermore, there is evidence that vitamin D may play a role in various other areas, including cardiovascular disease, immunological function, and the prevention of autoimmune illnesses and some cancers. [5][6] A range of problems in mineral metabolism leads to bone damage in patients with chronic kidney disease (CKD).…”

Section: Introductionmentioning

confidence: 99%

Effect of vitamin and mineral supplementation on nutritional status in children with chronic kidney disease: Protocol for a systematic review and meta-analysis

et al. 2022

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Background: Persistent kidney illness in children and those on dialysis therapy, risk of vitamin and mineral deficiencies due to abnormal renal metabolism, anorexia, inadequate intake, poor gastrointestinal absorption, drug-nutrient interaction, and dialysisrelated losses. Adequate nutritional management is essential to achieve and maintain an optimal nutritional status for the usual pattern of growth, sexual and neurocognitive development, metabolic abnormalities, and ultimately reducing the risk of chronic mortality and morbidity in adulthood. The purpose of this paper is to describe a protocol for a systematic review to assess the effects of vitamin and mineral supplementation in children with chronic renal disease.Methods: This systematic review protocol is developed according to the Preferred Reporting Item for Systematic Review and Meta-Analysis Protocols (PRISMA-P) as well as the Cochrane group guidelines. Comprehensive searching for all possible relevant works of literature-such as PubMed, Google Scholar, MEDLINE, Embase, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), Science-Direct, Scopus, Research-Gate, Clinical Trials for all randomized controlled studies, full paper articles, and articles written in English will be considered. The primary outcome of this review will be measuring any changes (such as changes in body mass, BMI, and overall Z-score) in the nutritional status of the children (age < 18 years) with chronic kidney disease following vitamin and mineral supplementations. This review will help better understand the effects of vitamin and mineral supplementation to improve nutritional status in CKD children and will create a guideline to determine the applicability of these interventions in different feasible settings. Conclusion:The systematic review protocol has been evaluated and approved by the institutional review board of North South University. Finding will be shared using traditional approaches, including scientific presentations, open-access peer-reviewed platforms.

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