Genetic factors adaptive in a malarial environment may increase the risk of type 1 diabetes遗传因素在疟疾环境中的自适应可能会增加1型糖尿病的风险

Gloria‐Bottini, F.; Bottini, E.

doi:10.1111/1753-0407.12250

Cited by 1 publication

(1 citation statement)

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“…To the best of our knowledge, there were only three genetic investigations to establish the role of TP53 codon 72 polymorphism in T1D. Spitsina et al [20] have not found any associations, and Bitti et al [21] have suggested that the Arg/Arg genotype predispose to T1D in a sex-specific and age-specific manner, whereas Gloria-Bottini et al [22] have found increase in the Arg/Arg genotype in T1D vs. control subjects. In our study, T1D seemed to have little association (p = 0.04) with Arg/Pro carriers but not with the other genotypes nor alleles.…”

Section: Discussionmentioning

confidence: 96%

Associations of TP53 codon 72 polymorphism with complications and comorbidities in patients with type 1 diabetes

et al. 2021

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Wild-type TP53 plays an important role in the regulation of immune response and systemic inflammation. In type 1 diabetes (T1D), TP53 pathways are upregulated and an increased susceptibility to apoptosis is observed. We hypothesize that TP53 codon 72 polymorphism could be associated with complications and comorbidities in patients with T1D. We have investigated the associations of the TP53 codon 72 polymorphism with the T1D complications and comorbidities (retinopathy, nephropathy, hypertension, dyslipidemia, autoimmune thyroiditis, and celiac disease) in 350 patients. The key results of our approach are as follows: (1) In diabetic subjects, the Pro/Pro genotype is associated with an increased risk of microvascular complications, dyslipidemia, and celiac disease; (2) the Arg/Arg variant is associated with a decreased risk of autoimmune thyroiditis and celiac disease; (3) the Pro allele is associated with an increased risk of dyslipidemia, autoimmune thyroiditis, and celiac disease. Although further studies are required, our results for the first time indicate that the TP53 codon 72 polymorphism could be considered a genetic marker to predict the increased susceptibility to some T1D complications and comorbidities. Key messages We analyzed the TP53 codon 72 polymorphism in patients with T1D. Pro/Pro genotype is associated with an increased risk of microvascular complications, dyslipidemia, and celiac disease. The Arg/Arg variant is associated with a decreased risk of autoimmune thyroiditis and celiac disease. The Pro allele is associated with an increased risk of dyslipidemia, autoimmune thyroiditis, and celiac disease.

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Section: Discussionmentioning

confidence: 96%