Genetic factors and clinical significance of acanthosis nigricans in obese Japanese children and adolescents

Miura, Noriaki; Ikezaki, Ayako; Iwama, Saika; Matsuoka, Hisafumi; Itō, Keiko; Sugihara, Shigetaka

doi:10.1111/j.1651-2227.2006.tb02202.x

Cited by 12 publications

(13 citation statements)

References 33 publications

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“…In the present study, patients with AN had significantly higher BMI than obese control subjects without AN. This is in agreement with the results of other studies that have reported the BMI of subjects with AN to be significantly greater than that in subjects without AN …”

Section: Discussionsupporting

confidence: 93%

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Serum leptin, adiponectin, and resistin among adult patients with acanthosis nigricans: correlations with insulin resistance and risk factors for cardiovascular disease

et al. 2013

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Section: Discussionsupporting

confidence: 93%

“…However, the correlation of serum leptin with other CVD risk factors was not studied. Similarly, Miura et al . reported that serum leptin was significantly higher in obese children and adolescents with AN than in obese control subjects.…”

Section: Discussionmentioning

confidence: 85%

Serum leptin, adiponectin, and resistin among adult patients with acanthosis nigricans: correlations with insulin resistance and risk factors for cardiovascular disease

et al. 2013

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“…Sendo assim, o achado de alta prevalência de fatores de risco para doença cardiovascular ateroscleró-tica, como circunferência da cintura aumentada, HDLcolesterol baixo e triglicérides altos, é preocupante. A alta prevalência de acantose nigricans, considerada marcador de resistência insulínica, mesmo em crianças (37)(38)(39)(40), também chama a atenção.…”

Section: Discussionunclassified

Ponto de corte do índice Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) avaliado pela curva Receiver Operating Characteristic (ROC) na detecção de síndrome metabólica em crianças pré-púberes com excesso de peso

Madeira

Carvalho

Mussi

et al. 2008

Arq Bras Endocrinol Metab

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RESUMOObjetivo: Estabelecer, entre os pontos de corte do índice homeostatic model assessment for insulin resistance (HOMA-IR), citados na literatura, o melhor em identifi car a síndrome metabólica (SM) em crianças com obesidade e sobrepeso. Métodos: Foram estudadas 140 crianças pré-púberes. A defi nição de SM foi adaptada da International Diabetes Federation. Para cada ponto de corte de HOMA-IR foram estimados sensibilidade e especifi cidade, tomandose como desfecho a SM. Uma curva receiver operating characteristic (ROC) foi construída com estes valores. Resultados: O grupo estudado constituiu-se de 106 crianças com obesidade (37 meninas e 69 meninos) e 34 com sobrepeso (19 meninas e 15 meninos), média de idade 6,5 ± 2,3 anos. A acurácia da curva ROC foi 72%, e o melhor ponto de corte foi 2,5, com sensibilidade 61% e especifi cidade 74%. Conclusões: O índice HOMA-IR pode ser útil para detectar a SM, e o ponto de corte 2,5 mostrou-se o melhor para crianças pré-pú-beres com obesidade e sobrepeso. Objective: To establish, among the cut-off values for the homeostatic model assessment for insulin resistance index (HOMA-IR) cited in the literature, the best in identifying metabolic syndrome (MS) in obese and overweight children. Methods: A total of 106 pre-pubertal children were studied. The defi nition of MS was adapted from that of the International Diabetes Federation. For each cut-off values for HOMA-IR, it was estimated sensibility and specifi city for MS. A receiver operating characteristic (ROC) curve was generated using these values. Results: The study included 106 obese (37 girls and 69 boys) and 34 overweight (19 girls and 15 boys) children aged 6,5 ± 2,3 years. The accuracy of the ROC curve was 72%, and the best cut-off value for HOMA-IR was 2,5, with sensitivity of 61% and specifi city of 74%. Conclusions: HO-MA-IR may be useful to detect MS and the cut-off 2,5 seems to be the best in obese and overweight pre-pubertal children.

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“…8,9 Although the rates of AN and obesity are different among races, a close association between these clinical findings and IR was documented in children from many countries and various ethnicities. 3,9,[10][11][12][13][14][15][16] The investigation of IR status requires a blood withdrawn under fasting condition and is associated with pain, patient's reluctance, and poor compliance. Thus, the clinical dermatological finding of AN may offer an easier solution to detect IR in obese children with better patient's compliance and parents acceptance.…”

Section: Introductionmentioning

confidence: 99%

Acanthosis Nigricans as a Clinical Marker to Detect Insulin Resistance in Caucasian Children From West Virginia

Aswani

Lochow

Dementieva

et al. 2011

Clin Pediatr (Phila)

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The accuracy of acanthosis nigrcans (AN) as a dermatological clinical marker to predict insulin resistance (IR) has not been well established in children. A cohort of obese Caucasian children was prospectively recruited. Demographic data, body mass index values, and laboratory data were compared for the presence or absence of AN. A total of 76 children participated. In all, 46 (60.5%) children had AN, and 34 (44.7%) children were positive for IR (>3.16); 25 (32.9%) children were positive for both AN and IR. Sensitivity, specificity, positive and negative predictive values, and accuracy level for AN to detect IR in the obese children who participated in this study were 73.5%, 50%, 54.3%, 70%, and 49%, respectively. The correlation between insulin and fasting glucose levels in AN-negative or AN-positive patients was low (R (2) = 13% to 17%). Acanthosis nigricans was only a surrogate marker for IR. It is concluded that IR should be examined in every obese West Virginian child irrespective of his or her AN status.

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Genetic factors and clinical significance of acanthosis nigricans in obese Japanese children and adolescents

Abstract: We demonstrate that AN is a useful clinical marker for the severity of obesity associated with a high BMI, and that B2ADR Gly16 and B3ADR Arg64 are associated synergistically with AN in obese children and adolescents.

Cited by 12 publications

References 33 publications

Serum leptin, adiponectin, and resistin among adult patients with acanthosis nigricans: correlations with insulin resistance and risk factors for cardiovascular disease

Serum leptin, adiponectin, and resistin among adult patients with acanthosis nigricans: correlations with insulin resistance and risk factors for cardiovascular disease

Ponto de corte do índice Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) avaliado pela curva Receiver Operating Characteristic (ROC) na detecção de síndrome metabólica em crianças pré-púberes com excesso de peso

Acanthosis Nigricans as a Clinical Marker to Detect Insulin Resistance in Caucasian Children From West Virginia

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