Genetic factors associated with obesity risks in a Kazakhstani population

Razbekova, Madina; Chan, Mei-Yen; Chan, Robbie; Yerezhepov, Dauren; Kozhamkulov, Ulan; Akilzhanova, Ainur; Chan, Chee–Kai

doi:10.1136/bmjnph-2020-000139

Cited by 7 publications

(7 citation statements)

References 65 publications

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“…In several studies it was observed that Egyptian and Tunisian studies showed no statistically significant results, and this is consistent with the current study 47,48 . Other research, contradicting the present study findings, in the Romanian and Kazakhs populations carriers with either genotype had the inverse effect, particularly being related to an increased obesity risk 28,49 . There is also another study in Poland that revealed no statistically significant results, therefore does not agree with the current study results 50 .…”

Section: Discussioncontrasting

confidence: 99%

Investigation of the association of AGTR1 A1166C rs5186 and FTO rs9939609 polymorphisms with the obesity in children and adolescents

Ali

Teplyakova²,

Bocharova³

et al. 2022

Baghdad Sci.J

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Obesity is a risk factor for a number of chronic conditions. Obesity is clinically defined using the body mass index (BMI) as weight in kg divided by (height)2 in m2 correlated with obesity. Currently, genetic markers of obesity are being studied. This study focused on the association between the angiotensin II receptor AGTR1 gene (A1166C) and fat mass and obesity-associated protein also known as alpha-ketoglutarate-dependent dioxygenase (FTO) (rs9939609) in obese children and adolescents patients in Rostov region, Russia. Five-hundreds of Russian nationality child and adolescent were recruited for the obesity-control studies. The relationship between the A1166C polymorphism of the AGTR1 gene in 300 children and adolescents included as the unhealthy group, compared with healthy group of 200 participants were investigated. Genotyping of A1166C polymorphisms of the AGTR1 rs5186 gene was performed using PCR allele-specific primers. Polymorphisms of the AGTR1 A1166C (rs5186) genes in donor DNA samples were typed by the electrophoretic method using commercial test systems from the Lytech research and production company. The relationship between obesity and AGTR1 gene polymorphism (A1166C) was not established between the obesity and control groups in terms of the frequency of occurrence of the CC genotype (P = 1.000) and (OR 1.05; 95% CI (0.53 – 2.10)) and the C allele (P = 0.942) and (OR 1.01; 95% CI (0.76 – 1.35)). However, in the occurrence of frequency genotype of AA (P = 0.003; OR 0.57; 95% CI (0.39 – 0.82)) and T (P = 0.006) of allele and (OR 1.44; 95% CI (1.11 – 1.87)) the rs9939609 of the FTO gene were revealed differences (P <0.05) between patients and control groups. The association between genotypes obesity risk was indicated, and a significant relationship was shown between the occurrence of obesity with the FTO rs9939609 polymorphism.

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Section: Discussioncontrasting

confidence: 99%

Investigation of the association of AGTR1 A1166C rs5186 and FTO rs9939609 polymorphisms with the obesity in children and adolescents

Ali

Teplyakova²,

Bocharova³

et al. 2022

Baghdad Sci.J

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“…Interesting data is presented by the Swedish Pregnancy, Obesity and Pelvic floor (SWEPOP) project: with each unit exceeding the normal value of the body mass index (BMI), the risk of developing symptomatic POP increases by 3% [27]. Currently, obesity also is one of the main problems in our country [28]. In this study, all the patients were overweight as a risk factor for POP, which is consistent with the results of previous studies [29].…”

Section: Discussionsupporting

confidence: 89%

Effects of unilateral apical sling and laparoscopic sacrocolpopexy on the outcome in women with apical prolapse: randomised trial

Aitbayeva

Iskakov

Lushchaeva³

et al. 2023

Ginekol Pol

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Objectives:The purpose of this study was to compare the use of unilateral apical sling versus laparoscopic sacrocolpopexy in the treatment of the apical form of pelvic organ prolapse in women. Material and methods:A prospective, single-center randomized trial included 100 patients who were alternately assigned to treatment. Each patient had a ≥ III stage of apical or anterior-apical prolapse determined by the POP-Q system. 45 accepted for unilateral apical sling (UAS) and 55 accepted for laparoscopic sacrocolpopexy (LS). Data were compared by the One-way ANOVA test using IBM SPSS stats 19.Results: Mean operating time was significantly greater in the LS group versus UAS group, 194.6 vs 42.4 minutes, respectively (p < 0.05). The amount of intraoperative bleeding was significantly higher in the UAS group, compared to the LS group (p = 0.01). Within the follow-up period, 2 patients in UAS group and 3 patients in LS group (4.4% vs 5.4%, respectively; p = 0.9) had recurrent cystocoele. HRQoL and sexual outcomes did not differ significantly between the two treatment groups. Conclusions:Our data demonstrate the non-superiority one on each other of the two different approaches, except in terms of shorter operating time and higher intraoperative bleeding when UAS used. These findings raise questions about the need for long-term results of quality of life outcomes for women with genital prolapse, especially in resource-limited settings similar to Kazakhstan.

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“…37 , 38 B12 deficiency is also associated with obesity. 58 , 59 Obesity and insulin resistance are two major risk factors for T2D. Indians as a group have a substantial prevalence of vitamin B12 deficiency.…”

Section: Discussionmentioning

confidence: 99%

Polygenic scores of diabetes-related traits in subgroups of type 2 diabetes in India: a cohort study

Yajnik

Wagh

Kunte

et al. 2023

The Lancet Regional Health - Southeast Asia

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Genetic factors associated with obesity risks in a Kazakhstani population

Cited by 7 publications

References 65 publications

Investigation of the association of AGTR1 A1166C rs5186 and FTO rs9939609 polymorphisms with the obesity in children and adolescents

Investigation of the association of AGTR1 A1166C rs5186 and FTO rs9939609 polymorphisms with the obesity in children and adolescents

Effects of unilateral apical sling and laparoscopic sacrocolpopexy on the outcome in women with apical prolapse: randomised trial

Polygenic scores of diabetes-related traits in subgroups of type 2 diabetes in India: a cohort study

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