Genetic Factors for Coronary Heart Disease and Their Mechanisms: A Meta-Analysis and Comprehensive Review of Common Variants from Genome-Wide Association Studies

Zarkasi, Khairul Anwar; Abdullah, Nor Azizan; Murad, Nor Azian Abdul; Ahmad, Norfazilah; Jamal, Rahman

doi:10.3390/diagnostics12102561

Cited by 6 publications

(3 citation statements)

References 221 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is also worth noting that atherosclerosis susceptibility is influenced by genetic factors, with polymorphisms in genes related to lipid metabolism (e.g., APOE), inflammation (e.g., IL-6), and vascular function (e.g., eNOS) playing significant roles. Epigenetic modifications, including DNA methylation and histone acetylation, further regulate the expression of genes associated with atherosclerosis [60][61][62].…”

Section: Pathogenesis Of Atherosclerosismentioning

confidence: 99%

Photodynamic Therapy for Atherosclerosis

Mytych,

Bartusik-Aebisher,

Łoś

et al. 2024

IJMS

View full text Add to dashboard Cite

Atherosclerosis, which currently contributes to 31% of deaths globally, is of critical cardiovascular concern. Current diagnostic tools and biomarkers are limited, emphasizing the need for early detection. Lifestyle modifications and medications form the basis of treatment, and emerging therapies such as photodynamic therapy are being developed. Photodynamic therapy involves a photosensitizer selectively targeting components of atherosclerotic plaques. When activated by specific light wavelengths, it induces localized oxidative stress aiming to stabilize plaques and reduce inflammation. The key advantage lies in its selective targeting, sparing healthy tissues. While preclinical studies are encouraging, ongoing research and clinical trials are crucial for optimizing protocols and ensuring long-term safety and efficacy. The potential combination with other therapies makes photodynamic therapy a versatile and promising avenue for addressing atherosclerosis and associated cardiovascular disease. The investigations underscore the possibility of utilizing photodynamic therapy as a valuable treatment choice for atherosclerosis. As advancements in research continue, photodynamic therapy might become more seamlessly incorporated into clinical approaches for managing atherosclerosis, providing a blend of efficacy and limited invasiveness.

show abstract

Section: Pathogenesis Of Atherosclerosismentioning

confidence: 99%

Photodynamic Therapy for Atherosclerosis

Mytych,

Bartusik-Aebisher,

Łoś

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…The analysis of the multiple dataset provides a good result with the developed research. In [6] S. Satoh has proposed a sequence analysis of the face extraction which tends to give out from the video. A key frame Extraction technique has been generated with the extracted with multiple level of face content detection.…”

Section: Literature Surveymentioning

confidence: 99%

Child Missing with Surveillance Analysis with Multi Phase Extraction Face Monitoring

Latha

2024

IJRASET

View full text Add to dashboard Cite

Visual Surveillance has been placed in everywhere for any incidents identification. With the wide developments missing child identification with the computer vision system is the main focus. The implementation carried out with face based detection with rapid advance digital connectivity. Face recognition plays as a major developmental process where the concern person can be identified with face based identification system. Machine learning with artificial intelligence plays a vital role in facial detection and recognition. The paper proposes Haar Cascade on feature extraction from facial points and Hybrid Recurrent Neural System(HRNN) with Long Short Term Memory(LSTM) algorithm, on multi face recognition over public crowded area. Missing child images will be pre- trained in a database where the face matching templates will be provided. On matching the database labeled points with the feature point an E-mail or SMS based alert system can be generated on notification to the authority with cam points. Thus the development carried will give best accuracy solution on finding out from multiple face regions. Mainly identification of the missing child over the road side areas will be done with computer vision frame targeting system.

show abstract

“…Since its initial identification, LRP1 has also been shown to be highly expressed in a variety of cell types, interact with a broad range of macromolecular substrates, and control cell functions in a cell type-and context-dependent manner. Several studies revealing that LRP1 gene polymorphisms are connected with a broad spectrum of disorders serve as the finest illustration of the significance of these LRP1 roles in health maintenance and disease protection [112,113]. However, we do not yet fully understand the underlying mechanisms through which LRP1 malfunction encourages obesity, diabetes, and fatty liver disease.…”

Section: Low-density Lipoprotein Receptor (Ldlr)mentioning

confidence: 99%

Molecular Mechanisms and Mediators of Hepatotoxicity Resulting from an Excess of Lipids and Non-Alcoholic Fatty Liver Disease

Finelli

2023

Gastrointestinal Disorders

View full text Add to dashboard Cite

The paper reviews some of the mechanisms implicated in hepatotoxicity, which is induced by an excess of lipids. The paper spans a wide variety of topics: from the molecular mechanisms of excess lipids, to the therapy of hyperlipidemia, to the hepatotoxicity of lipid-lowering drugs. NAFLD is currently the leading cause of chronic liver disease in Western countries; the molecular mechanisms leading to NAFLD are only partially understood and there are no effective therapeutic interventions. The prevalence of liver disease is constantly increasing in industrialized countries due to a number of lifestyle variables, including excessive caloric intake, unbalanced diet, lack of physical activity, and abuse of hepatotoxic medicines. Considering the important functions of cell death and inflammation in the etiology of the majority, if not all, liver diseases, one efficient therapeutic treatment may include the administration of hepatoprotective and anti-inflammatory drugs, either alone or in combination. Clinical trials are currently being conducted in cohorts of patients with different liver diseases in order to explore this theory.

show abstract

Genetic Factors for Coronary Heart Disease and Their Mechanisms: A Meta-Analysis and Comprehensive Review of Common Variants from Genome-Wide Association Studies

Cited by 6 publications

References 221 publications

Photodynamic Therapy for Atherosclerosis

Photodynamic Therapy for Atherosclerosis

Child Missing with Surveillance Analysis with Multi Phase Extraction Face Monitoring

Molecular Mechanisms and Mediators of Hepatotoxicity Resulting from an Excess of Lipids and Non-Alcoholic Fatty Liver Disease

Contact Info

Product

Resources

About