Genetic Factors in Male Pattern Alopecia

Multifactorial Classification of Male and Female Androgenetic Alopecia

“…Male or female androgenetic alopecia induces a relatively early hair loss phenomenon of varying incidence and extent. 1 Several intermediate evolutive stages exist between minimal thinning due to a decrease in hair density (frontotemporal recessions, crown, or vertex) and the stage where only a narrow horseshoe‐shaped band remains. Classifications of baldness require a more objective, precise, and detailed approach for the different modifications determined by the evolutive process.…”

Hair Restoration Surgery in Patients with Pubic Atrichosis or Hypotrichosis: Review of Technique and Clinical Consideration of 507 Cases

“…The current literature suggests that the genetic predisposition to androgenetic alopecia is most likely linked to an increased androgen sensitivity of the hair follicles in the affected areas of the scalp. 14 In contrast, patients with pubic atrichosis or hypotrichosis appear to have a deficiency of androgen receptors or an androgen insusceptibility in their pubic hair follicles, which is likely inherited as a polygenic trait. Pubic atrichosis or hypotrichosis is also more commonly seen in Mongolian women, suggesting racial predisposition.…”

Die pathogenetische Bedeutung der 5α-Reduktase-Isoenzyme für die androgenetische Alopezie

“…Zahlreiche Vererbungsmodi der androgenetischen Alopezie wurden bis heute diskutiert.Vermutet wurde ein autosomal-dominanter Erbgang mit variabler Penetranz [5,48,52], wenngleich am wahrscheinlichsten ein polygenetischer Erbgang ist [19,38]. Spezifische Gene, welche die Veranlagung und die Ausprägung der androgenetischen Alopezie determinieren, sind ebenfalls noch nicht identifiziert.…”