2001
DOI: 10.1006/mgme.2000.3130
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Genetic Factors Related to Racial Variation in Plasma Levels of Insulin-Like Growth Factor-1: Implications for Premenopausal Breast Cancer Risk

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Cited by 99 publications
(108 citation statements)
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“…We have not typed a CA repeat polymorphism located in the 5 0 region of IGF1, between SNPs rs35767 and rs2162679, which has been frequently included in previous studies. Several epidemiological studies on the association between this polymorphism and breast cancer risk or IGF-I levels (Jernstrom et al, 2001a;Yu et al, 2001;Figer et al, 2002;Missmer et al, 2002;DeLellis et al, 2003) have yielded highly conflicting results. This microsatellite polymorphism has a large number of alleles, which results in fractioning the study population into a large number of classes.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…We have not typed a CA repeat polymorphism located in the 5 0 region of IGF1, between SNPs rs35767 and rs2162679, which has been frequently included in previous studies. Several epidemiological studies on the association between this polymorphism and breast cancer risk or IGF-I levels (Jernstrom et al, 2001a;Yu et al, 2001;Figer et al, 2002;Missmer et al, 2002;DeLellis et al, 2003) have yielded highly conflicting results. This microsatellite polymorphism has a large number of alleles, which results in fractioning the study population into a large number of classes.…”
Section: Discussionmentioning
confidence: 99%
“…So far, however, only few studies have been conducted to identify specific gene variants that influence circulating IGF-I levels, even though such research is currently intensifying (Hasegawa et al, 2000;Lopez-Bermejo et al, 2000;Jernstrom et al, 2001a;Vaessen et al, 2001).…”
mentioning
confidence: 99%
“…Most white women have at least one copy of the 19-repeat allele (Jernström et al, 2001b), but the frequency of the 19-repeat allele varies between ethnic groups (Jernström et al, 2001a). Insulin-like growth factor-1 levels decrease in most white OC users compared with white non-users (Jernström and Olsson, 1994).…”
mentioning
confidence: 99%
“…The 19 CA-repeat allele is the most common in whites (Jernström et al, 2001a;Schildkraut et al, 2005). Studies of other genes indicate that the number of CA repeats in a promoter region is inversely correlated with transcription activity (Gebhardt et al, 1999;Tae et al, 1994).…”
mentioning
confidence: 99%
“…A non-significant trend of decreasing IGF-1 levels with increasing number of repeats has been reported (Figer et al, 2002). The level of IGF-1 is also influenced by other factors, such as oral contraceptive (OC) use (Jernström & Barrett-Connor, 1999;Jernström et al, 2001a;Jernström et al, 2001b;Narod et al, 2002). We have previously reported that the IGF1-19/-19 genotype was more common among known BRCA1 mutation carriers than among other healthy women from highrisk breast cancer families of various types (i.e.…”
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confidence: 99%