Genetic Mapping of Social Interaction Behavior in B6/MSM Consomic Mouse Strains

Takahashi, Akiyoshi; Tomihara, Kazuya; Shiroishi, Toshihiko; Koide, Tsuyoshi

doi:10.1007/s10519-009-9312-x

Cited by 28 publications

(27 citation statements)

References 46 publications

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“…In our laboratory, we use a consomic strain of the wild-derived mouse strain MSM/Ms and a common laboratory strain C57BL/6J (Takada et al, 2008). Male MSM mice are highly aggressive in the home cage and sometimes kill their littermates, and we found enhanced aggression in the consomic strains that have either Chr 4 or Chr 15 from MSM on the C57BL/6J background (Takahashi et al, 2010d; in preparation).…”

Section: Forward Genetics Of Aggressive Behavior In Rodentsmentioning

confidence: 80%

Neurogenetics of Aggressive Behavior: Studies in Rodents

Takahashi

Miczek

2013

Current Topics in Behavioral Neurosciences

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Aggressive behavior is observed in many animal species, such as insects, fish, lizards, frogs, and most mammals including humans. This wide range of conservation underscores the importance of aggressive behavior in the animals’ survival and fitness, and the likely heritability of this behavior. Although typical patterns of aggressive behavior differ between species, there are several concordances in the neurobiology of aggression among rodents, primates, and humans. Studies with rodent models may eventually help us to understand the neurogenetic architecture of aggression in humans. However, it is important to recognize the difference between the ecological and ethological significance of aggressive behavior (species-typical aggression) and maladaptive violence (escalated aggression) when applying the findings of aggression research using animal models to human or veterinary medicine. Well-studied rodent models for aggressive behavior in the laboratory setting include the mouse (Mus musculus), rat (Rattus norvegicus), hamster (Mesocricetus auratus), and prairie vole (Microtus ochrogaster). The neural circuits of rodent aggression have been gradually elucidated by several techniques e.g. immunohistochemistry of immediate-early gene (c-Fos) expression, intracranial drug microinjection, in vivo microdialysis, and optogenetics techniques. Also, evidence accumulated from the analysis of gene-knockout mice shows the involvement of several genes in aggression. Here we review the brain circuits that have been implicated in aggression, such as the hypothalamus, prefrontal cortex (PFC), dorsal raphe nucleus (DRN), nucleus accumbens (NAc), and olfactory system. We then discuss the roles of glutamate and γ-aminobutyric acid (GABA), major inhibitory and excitatory amino acids in the brain, as well as their receptors, in controlling aggressive behavior, focusing mainly on recent findings. At the end of this chapter, we discuss how genes can be identified that underlie individual differences in aggression, using the so-called forward genetics approach.

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Section: Forward Genetics Of Aggressive Behavior In Rodentsmentioning

confidence: 80%

Neurogenetics of Aggressive Behavior: Studies in Rodents

Takahashi

Miczek

2013

Current Topics in Behavioral Neurosciences

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190

132

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“…We chose to use only females in this experiment despite the potential complication of the estrous cycle owing to our decision to separate the sexes early post weaning and house the experimental subjects communally. In some of the wild-derived strains, males are aggressive and harm, even kill, one another when housed in this manner (Takahashi et al, 2010). Therefore, we were unable to keep male littermates of some of the wild-derived strains in the same cage.…”

Section: Materials and Methods Micementioning

confidence: 99%

Ultradian components in the locomotor activity rhythms of the genetically normal mouse,Mus musculus

Dowse

Umemori

Koide

2010

Journal of Experimental Biology

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SUMMARYUltradian periodicities in physiological processes have been reported for a wide variety of organisms and may appear as bouts in locomotor activity. In some instances, this temporal organization can be related to some ethological strategy. In mice, however, ultradian rhythms have been reported largely in animals with circadian pacemakers disrupted either by genetic or surgical manipulation. Using analysis techniques capable of resolving periodicities in the ultradian range in the presence of strong diel periodicity, we found unequivocal evidence of ultradian rhythms in mice entrained to an light:dark cycle. We collected locomotor activity data of individuals from 11 genetically disparate strains of mice whose activity was recorded in 12h:12h L:D photoperiods for 3days. Data were subjected to maximum entropy spectral analysis and autocorrelation, both before and after filtering to remove the 24-h periodicity. We found that every strain had a majority of individuals with strong ultradian rhythms ranging from 3 to ~5h. These periodicities were commonly visible in individual animals both in high-pass-filtered and in unfiltered data. Furthermore, when all raw data from a given strain were pooled to get a 24-h ensemble average across all animals and days, the rhythms continued to be discernable. We fitted Fourier series to these form estimates to model the frequency structure of each strain and found significant effects of strain and an interaction between period and strain indicating significant genetic variation for rhythmicity in the ultradian range. The techniques employed in this study should have wider use in a range of organisms and fields.

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“…Significant resistance to age-dependent hearing loss has been reported [26,32]. Unique wild-derived behavioral traits including very high locomotor activity are also characteristic of MSM [21,33,56,57]. additionally, this strain was selected as one of the target strains in the Mouse Phenome Project of the Jackson Laboratory, and the accumulated phenotypic data are now available online [16,39].…”

Section: Japanese Wild-mouse-derived Inbred Strain For Studies Of Quamentioning

confidence: 99%

Complex Quantitative Traits Cracked by the Mouse Inter-Subspecific Consomic Strains

Takada

Shiroishi

2012

Exp. Anim.

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Mammalian quantitative traits that are observed at the whole-body level, such as body weight and length and blood biochemical parameters, are determined by the cooperative effects of multiple genetic and epigenetic factors as well as environmental factors. This complexity has hampered the genetic analysis of quantitative traits. To overcome this difficulty, we have established a full set of consomic mouse strains, also known as chromosome substitution strains, by replacing every chromosome of the classical inbred strain C57BL/6J with its counterpart from the Japanese wildmouse-derived inbred strain MSM/Ms. The core components of the genomes of these two strains originated from different mouse subspecies. The inter-subspecific large-genome divergence and phenotypic differences between the two strains allowed the identification of genetic determinants for many quantitative traits by comprehensive phenotype screening. For some quantitative traits, the genetic determinants could be dissected into multiple chromosomes, thereby reflecting strain differences between C57BL/6J and MSM/Ms and their simple additive effects on the background of the consomic host strain. For other quantitative traits, the measured values of some consomic strains often far exceeded the range of the two parental strains, which suggests that nonadditive genetic interactions occur among multiple genes located on the substituted MSM/Ms chromosomes and the consomic host chromosomes. Thus, the inter-subspecific consomic strains are unique tools that can be used to identify both additive and nonadditive genetic effects on quantitative complex traits.

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Genetic Mapping of Social Interaction Behavior in B6/MSM Consomic Mouse Strains

Cited by 28 publications

References 46 publications

Neurogenetics of Aggressive Behavior: Studies in Rodents

Neurogenetics of Aggressive Behavior: Studies in Rodents

Ultradian components in the locomotor activity rhythms of the genetically normal mouse,Mus musculus

Complex Quantitative Traits Cracked by the Mouse Inter-Subspecific Consomic Strains

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