Genetic mapping of the autosomal region involved in XX sex-reversal and horn development in goats

Vaiman, Daniel; Koutita, Olga; Oustry, Anne; Elsen, Jean-Michel; Manfredi, Eduardo; Fellous, Marc; Cribiu, Edmond

doi:10.1007/s003359900033

Cited by 72 publications

(44 citation statements)

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“…The chromosome 10 QTL overlapped with the horns locus, a locus controlling discrete horn phenotypes in domestic sheep (that is, presence versus absence of horns, Montgomery et al, 1996). On the other hand, no putative QTL overlapped with loci known to influence discrete horn polymorphisms in other bovid genera (Georges et al, 1993;Vaiman et al, 1996;Asai et al, 2004). This suggests that different genes may be responsible for quantitative and discrete variation in horn morphology among bovids.…”

Section: Discussionmentioning

confidence: 93%

QTL mapping for sexually dimorphic fitness-related traits in wild bighorn sheep

et al. 2011

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Dissecting the genetic architecture of fitness-related traits in wild populations is key to understanding evolution and the mechanisms maintaining adaptive genetic variation. We took advantage of a recently developed genetic linkage map and phenotypic information from wild pedigreed individuals from Ram Mountain, Alberta, Canada, to study the genetic architecture of ecologically important traits (horn volume, length, base circumference and body mass) in bighorn sheep. In addition to estimating sex-specific and cross-sex quantitative genetic parameters, we tested for the presence of quantitative trait loci (QTLs), colocalization of QTLs between bighorn sheep and domestic sheep, and sexÂQTL interactions. All traits showed significant additive genetic variance and genetic correlations tended to be positive. Linkage analysis based on 241 microsatellite loci typed in 310 pedigreed animals resulted in no significant and five suggestive QTLs (four for horn dimension on chromosomes 1, 18 and 23, and one for body mass on chromosome 26) using genome-wide significance thresholds (Logarithm of odds (LOD) 43.31 and 41.88, respectively). We also confirmed the presence of a horn dimension QTL in bighorn sheep at the only position known to contain a similar QTL in domestic sheep (on chromosome 10 near the horns locus; nominal Po0.01) and highlighted a number of regions potentially containing weight-related QTLs in both species. As expected for sexually dimorphic traits involved in male-male combat, loci with sex-specific effects were detected. This study lays the foundation for future work on adaptive genetic variation and the evolutionary dynamics of sexually dimorphic traits in bighorn sheep.

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Section: Discussionmentioning

confidence: 93%

QTL mapping for sexually dimorphic fitness-related traits in wild bighorn sheep

et al. 2011

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“…These efforts culminated in the first draft of the ovine reference genome (Archibald et al, 2010), which has been improved further and the current released reference assembly, Oar v3.1, has a contig N50 length of~40 Kb and a total assembled length of 2.61 Gb, with~99% anchored onto the 26 autosomes and the X chromosome (Jiang et al, 2014). In contrast, similar efforts at developing and refining the goat genome have lagged behind, but recent years have witnessed a slow increase in gene mapping data since the first genetic and cytogenetic maps were produced (Vaiman et al, 1996;Schibler et al, 1998) and 550 loci have been mapped to the goat genome using linkage maps of low resolution (Schibler et al, 2009). The initial release of the goat genome sequence (Dong et al, 2013) was based entirely on short-read de novo sequencing that yielded an~2.66 Gb assembly with a contig N50 length of 3.06 Mb.…”

Section: Discussionmentioning

confidence: 99%

Multiple genomic signatures of selection in goats and sheep indigenous to a hot arid environment

et al. 2015

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Goats and sheep are versatile domesticates that have been integrated into diverse environments and production systems. Natural and artificial selection have shaped the variation in the two species, but natural selection has played the major role among indigenous flocks. To investigate signals of natural selection, we analyzed genotype data generated using the caprine and ovine 50K SNP BeadChips from Barki goats and sheep that are indigenous to a hot arid environment in Egypt's Coastal Zone of the Western Desert. We identify several candidate regions under selection that spanned 119 genes. A majority of the genes were involved in multiple signaling and signal transduction pathways in a wide variety of cellular and biochemical processes. In particular, selection signatures spanning several genes that directly or indirectly influenced traits for adaptation to hot arid environments, such as thermo-tolerance (melanogenesis) (FGF2, GNAI3, PLCB1), body size and development (BMP2, BMP4, GJA3, GJB2), energy and digestive metabolism (MYH, TRHDE, ALDH1A3), and nervous and autoimmune response (GRIA1, IL2, IL7, IL21, IL1R1) were identified. We also identified eight common candidate genes under selection in the two species and a shared selection signature that spanned a conserved syntenic segment to bovine chromosome 12 on caprine and ovine chromosomes 12 and 10, respectively, providing, most likely, the evidence for selection in a common environment in two different but closely related species. Our study highlights the importance of indigenous livestock as model organisms for investigating selection sweeps and genome-wide association mapping.

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“…The lack of development of the goat map is not surprising given that the goat map was developed specifically for a genome screen to map a single Mendelian trait, and that the region containing this locus was identified without the need for a full genome scan [26]. The only region mapped in depth on the goat genetic map is the region on chromosome 1 flanking the PISRT1 locus [21,28].…”

Section: Discussionmentioning

confidence: 99%

“…In the case of goats, the reason for developing a genetic map was to map the locus responsible for the Polled Intersex Syndrome [26], and relatively little genetic map development has occurred for goats since this locus was mapped. Initially, much of the work on the sheep genetic map was aimed at identifying loci responsible for fertility traits such as Inverdale and Booroola [12,20].…”

Section: Introductionmentioning

confidence: 99%

A presentation of the differences between the sheep and goat genetic maps

Maddox

2005

Genet. Sel. Evol.

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-The current autosomal version (4.2) of the sheep genetic map comprises 1175 loci and spans ∼3540 cM. This corresponds to almost complete coverage of the sheep genome. Each chromosome is represented by a single linkage group, with the largest gap between adjacent loci being 19.8 cM. In contrast the 1998 goat genetic map (the most recently published) is much less well developed spanning 2737 cM and comprising only 307 loci. Only one of the goat chromosomes appears to have complete coverage (chromosome 27), and 16 of the chromosomes are comprised of two or more linkage groups, or a linkage group and one or more unlinked markers. The two maps share 218 loci, and the maps have been aligned using the shared loci as reference points. Overall there is good agreement between the maps in terms of homologous loci mapping to equivalent chromosomes in the two species, with only four markers mapping to nonequivalent chromosomes. However, there are lots of inversions in locus order between the sheep and goat chromosomes. Whilst some of these differences in locus order may be genuine, the majority are likely to be a consequence of the paucity of genetic information for the goat map.genetic / linkage / sheep / goat / map

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Genetic mapping of the autosomal region involved in XX sex-reversal and horn development in goats

Cited by 72 publications

References 50 publications

QTL mapping for sexually dimorphic fitness-related traits in wild bighorn sheep

QTL mapping for sexually dimorphic fitness-related traits in wild bighorn sheep

Multiple genomic signatures of selection in goats and sheep indigenous to a hot arid environment

A presentation of the differences between the sheep and goat genetic maps

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