2016
DOI: 10.1007/s00296-016-3563-7
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Genetic markers as therapeutic target in rheumatoid arthritis: A game changer in clinical therapy?

Abstract: Rheumatoid arthritis (RA) is a chronic, inflammatory, multi-systemic autoimmune disease unremitted by genetic and environmental factors. The factors are crucial but inadequate in the development of disease; however, these factors can be representative of potential therapeutic targets and response to clinical therapy. Insights into the contribution of genetic risk factors are currently in progress with studies querying the genetic variation, their role in gene expression of coding and non-coding genes and other… Show more

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Cited by 11 publications
(10 citation statements)
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“…43-45 By detecting active inflammation in the joints or elsewhere early in patients known to be at risk for the development of RA, treatment may be able to be initiated earlier, even prior to clinical onset of disease. 46,47 …”
Section: Discussionmentioning
confidence: 99%
“…43-45 By detecting active inflammation in the joints or elsewhere early in patients known to be at risk for the development of RA, treatment may be able to be initiated earlier, even prior to clinical onset of disease. 46,47 …”
Section: Discussionmentioning
confidence: 99%
“…In addition, non-coding regions with the TRAF-C5 genetic region are associated with RA (42). Multiple genetic factors are also associated with certain biologic pathways in patients with established classified RA, typically relating to response to therapy, or toxicity, although how these factors influence the earliest stages of RA development remains to be determined (43, 44). Finally, several genetic factors are associated with decreased risk for RA, or the development of ACPA in RA (19).…”
Section: Genetic and Familial Risk Factors For Ramentioning
confidence: 99%
“…Rheumatoid arthritis (RA) is a chronic autoimmune disorder which affects approximately 1–2% of the world's population, being two to three times more common in women than in men. All RA patients suffer from mild disability, which can worsen in time and seriously damage the motor function (Ali and Vino, 2016 ; Cheung and McLnnes, 2017 ). Even more unfortunately, a large proportion of patients cannot tolerate current therapies and/or become insensitive to continuous exposure, which suggests that it is necessary to develop novel drugs to improve the existing treatment options for RA.…”
Section: Introductionmentioning
confidence: 99%