Genetic Markers for Coronary Artery Disease

Veljković, Nevena; Zarić, Božidarka; Djurić, Isidora; Obradović, Milan; Sudar-Milovanović, Emina; Radak, Djordje; Isenović, Esma R.

doi:10.3390/medicina54030036

Cited by 13 publications

(10 citation statements)

References 102 publications

(139 reference statements)

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“…CAD is a primary global public health challenge that is associated with severe health problems and economic burdens worldwide. 1,25 However, as a multifactorial disorder, CAD is influenced by the interaction of genetic and physical condition. 26 Dyslipidemia has a multifactorial origin, including environmental factors such as demographics, diet, alcohol consumption, cigarette smoking, and obesity.…”

Section: Discussionmentioning

confidence: 99%

PCSK9 E670G polymorphism increases risk of coronary artery disease in a Chinese Han population

et al. 2019

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Objective Coronary artery disease (CAD) is the leading cause of morbidity and mortality in the world. The proprotein convertase subtilisin/kexin type 9 ( PCSK9) E670G polymorphism has been reported to be associated with variability in levels of low density lipoprotein cholesterol, a risk factor for CAD. However, the relationship between PCSK9 E670G and CAD is still not fully elucidated. Methods A total of 225 patients and 189 control subjects were recruited in this study. DNA was extracted from peripheral blood samples and was genotyped by mass array method. In addition, we also conducted a meta-analysis of case-control studies to elucidate the relationship of CAD and polymorphism. Results The GG genotype of PCSK9 E670G was associated with a higher risk of CAD [odds ratio (OR) 2.994, 95% confidence interval (CI): 1.174–7.631], even adjusting for risk factors (OR 2.794, 95% CI: 1.215–7.460). Logistic regression analysis showed that the dominant genetic model increased the CAD risk (OR 2.313, 95% CI: 1.070–6.983) after adjusting the confounding factors. Meta-analysis results of 13 studies revealed that PCSK9 E670G polymorphism was correlated with CAD risk under different genetic models. Conclusion Our results demonstrated that PCSK9 E670G genotype was associated with a high risk of CAD.

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Section: Discussionmentioning

confidence: 99%

PCSK9 E670G polymorphism increases risk of coronary artery disease in a Chinese Han population

et al. 2019

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“…Up to now, modifiable and non-modifiable risk factors such as obesity, hypertension, smoking, diabetes, blood pressure, and sex have been studied [71,72,73,74]. It is also known that CVDs have high heredity and that 40–60% susceptibility is attributed to genetic factors [3]. To that basis, validation of candidate genes and elucidation of mechanisms underlying the pathophysiology of cardiovascular diseases provides deeper knowledge towards the development of new therapies.…”

Section: Investigation Of Human Cardiac Diseases Under the Light Omentioning

confidence: 99%

“…Nevertheless, population studies are revealing the genetic basis of CAD, highlighting also the complexity of its genetic causality [3]. The development of high-throughput genetic analysis technologies has provided the essential tools for identifying thousands of single nucleotide polymorphisms linked to CAD in large-scale population studies.…”

Section: Introductionmentioning

confidence: 99%

On Zebrafish Disease Models and Matters of the Heart

Giardoglou

Beis

2019

Biomedicines

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Coronary artery disease (CAD) is the leading form of cardiovascular disease (CVD), which is the primary cause of mortality worldwide. It is a complex disease with genetic and environmental risk factor contributions. Reports in human and mammalian models elucidate age-associated changes in cardiac function. The diverse mechanisms involved in cardiac diseases remain at the center of the research interest to identify novel strategies for prevention and therapy. Zebrafish (Danio rerio) have emerged as a valuable vertebrate model to study cardiovascular development over the last few decades. The facile genetic manipulation via forward and reverse genetic approaches combined with noninvasive, high-resolution imaging and phenotype-based screening has provided new insights to molecular pathways that orchestrate cardiac development. Zebrafish can recapitulate human cardiac pathophysiology due to gene and regulatory pathways conservation, similar heart rate and cardiac morphology and function. Thus, generations of zebrafish models utilize the functional analysis of genes involved in CAD, which are derived from large-scale human population analysis. Here, we highlight recent studies conducted on cardiovascular research focusing on the benefits of the combination of genome-wide association studies (GWAS) with functional genomic analysis in zebrafish. We further summarize the knowledge obtained from zebrafish studies that have demonstrated the architecture of the fundamental mechanisms underlying heart development, homeostasis and regeneration at the cellular and molecular levels.

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“…Despite improvement of living situations and increase in awareness over recent years, mortality rates due to these diseases are still too high in Poland, and data compiled in 2014 estimate that the number of deaths from cardiovascular disease in 2020 will exceed 200,000 [ 6 ]. Clinical studies show that genetic factors play a significant role in pathogenesis of CAD, and it is estimated that they may cause up to 60% of cases [ 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

VDR Gene Polymorphisms in Healthy Individuals with Family History of Premature Coronary Artery Disease

et al. 2021

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Aim. The gene encoding the vitamin D receptor (VDR) is considered in many studies to be a good candidate responsible for susceptibility to several diseases such as coronary artery disease (CAD). Epidemiological data show that cardiovascular disease is one of the major health problems in Polish society. Basic studies show that genetic factors play a significant role in the pathogenesis of CAD. We conducted this clinical study to determine if the VDR gene polymorphisms TaqI (rs731236), ApaI (rs7975232), and FokI (rs2228570) could predispose healthy individuals to an increased risk of premature CAD (P-CAD) incidents. Methods. We genotyped 845 subjects in a cohort consisting of 386 healthy volunteers with a documented P-CAD incident in their first-degree relatives and 459 healthy volunteers without family history (FH) of P-CAD. TaqI, ApaI, and FokI polymorphisms in VDR were genotyped using TaqMan assays and the endpoint genotyping method (qPCR). Statistical analyses were performed using the Power Analysis Software STATISTICA v.13.3. Results. Although no statistical significance was found for TaqI and ApaI genotype frequencies, the AA genotype of FokI polymorphism was significantly more frequent in the study group compared to the control group (24.61% vs. 16.99%). The results of logistic regression analysis suggested a significant association between FokI polymorphism and FH of P-CAD in heathy people under the recessive model (OR: 1.26 (1.07-1.49, p = 0.007 )); however, the frequency of VDR haplotypes did not differ significantly between the control and study populations. Conclusions. FokI polymorphism is may be associated with FH of P-CAD. FokI polymorphism may predispose to the development of P-CAD among healthy people over the next years.

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Genetic Markers for Coronary Artery Disease

Cited by 13 publications

References 102 publications

PCSK9 E670G polymorphism increases risk of coronary artery disease in a Chinese Han population

PCSK9 E670G polymorphism increases risk of coronary artery disease in a Chinese Han population

On Zebrafish Disease Models and Matters of the Heart

VDR Gene Polymorphisms in Healthy Individuals with Family History of Premature Coronary Artery Disease

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