2018
DOI: 10.1101/444380
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Genetic networks underlying natural variation in basal and induced activity levels inDrosophila melanogaster

Abstract: Exercise is recommended by health professionals across the globe as part of a healthy lifestyle to prevent and/or treat the consequences of obesity. While overall, the health benefits of exercise and an active lifestyle are well understood, very little is known about how genetics impacts an individual’s inclination for and response to exercise. To address this knowledge gap, we investigated the genetic architecture underlying natural variation in activity levels in the model system Drosophila melanogaster. Act… Show more

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Cited by 7 publications
(26 citation statements)
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“…There are genes that impact activity levels in only one sex, and genes affecting both sexes, which now can be investigated in follow‐up studies utilizing the various Drosophila mutant collections available. This study demonstrates the complex contributions of genetics to exercise response and illustrates the immense potential for Drosophila to contribute to exercise research . Several different populations for GWAS can be obtained from the community, and tools and established protocols are readily available to investigate exercise response rates such as body composition, physical fitness, cardiac health, metabolites, memory/learning and more .…”
mentioning
confidence: 91%
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“…There are genes that impact activity levels in only one sex, and genes affecting both sexes, which now can be investigated in follow‐up studies utilizing the various Drosophila mutant collections available. This study demonstrates the complex contributions of genetics to exercise response and illustrates the immense potential for Drosophila to contribute to exercise research . Several different populations for GWAS can be obtained from the community, and tools and established protocols are readily available to investigate exercise response rates such as body composition, physical fitness, cardiac health, metabolites, memory/learning and more .…”
mentioning
confidence: 91%
“…Dropping the enclosures results in the animals being knocked to the bottom of the enclosure, and due to their negative geotaxis response, they will attempt to climb to the top of the enclosure until they are dropped again . The Power Tower is a relatively intense form of exercise, and to induce a more gentle form of exercise, other groups have used partial (Swing Boat) or full rotations (Treadwheel, Rotating Exercise Quantification System [REQS], system developed by the Key Laboratory of Physical Fitness and Exercise Rehabilitation of Hunan Province at Hunan Normal University in China) of the animal enclosures to induce exercise. When the animal enclosures are rotated, the orientation of “up” changes, and the animals are stimulated to continue to move, leading to exercise compared to control flies.…”
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confidence: 99%
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