Genetic polymorphism in the sulfotransferase SULT1A1 gene in cancer

Pereira, Wogelsanger Oliveira; Paiva, Aldair Sousa; Queiroz, José W.; Toma, Leny; Dietrich, Carl P.; Nader, Helena B.; Jerônimo, Selma M. B.

doi:10.1016/j.cancergencyto.2004.12.005

Cited by 17 publications

(18 citation statements)

References 26 publications

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“…Sulfonation is thought to be a detoxification pathway for various xenobiotics, and it is also involved in the bioactivation of several carcinogens by O-esterification to form DNA-damaging toxic metabolites [8,11]. The G to A polymorphism at position 638 of SULT1A1 may result in reduced enzyme activity and reduced thermostability.…”

Section: Discussionmentioning

confidence: 99%

“…In particular, SULT1A1 appears to be a key phenol SULT because of its abundance and distribution in a wide range of tissues [10]. The common polymorphism of SULT1A1 involves a single nucleotide G to A transition at nucleotide 638 (codon 213) in exon 7, which results in an arginine (Arg) to histidine (His) amino acid substitution and this polymorphism may lead to a lower enzyme activity and thermostability [11]. Epidemiological studies have shown inconsistent results for the association between the SULT1A1 G638A polymorphism and several malignancies including bladder cancer, lung cancer and breast cancer [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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<i>Sulfotransferase</i> 1A1 G638A polymorphism, cigarette smoking and bladder cancer risk in Taiwan

Shen¹,

Wu²,

Wang³

et al. 2012

ABB

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Cigarette smoking is a major risk factor for bladder cancer (BC). Sulfotransferase 1A1 (SULT1A1), a phase II enzyme, plays an important role in the metabolism of several carcinogens contained in cigarettes. The aim of this study was to investigate the relationship between SULT1A1 G638A polymorphism, cigarette smoking and bladder cancer risk in Taiwan. A total of 150 BC patients and 150 cancer-free controls were recruited from February 2002 to February 2009. Genotyping of the SULT1A1 G638A polymerphism was determined using the polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) method. The odds ratio (OR) and 95% confidence interval (CI) were calculated as a measure of the combined effect of cigarette smoking and the SULT1A1 G638A polymorphism on BC risk. In the present study, we found that study subjects with the G/G genotype of the SULT1A1 gene had a significantly higher BC risk of 1.7 (95% CI = 1.3 -3.2) compared with those carrying the combination of G/A and A/A genotypes. Moreover, ever smokers who carried the G/G genotype of the SULT1A1 gene had a significantly increased UC risk of 3.5 (95% CI = 2.5 -10.2) compared with never smokers who carried the G/A and A/A genotypes as the reference group. In conclusion, our findings suggest that SULT1A1 G638A polymorphism is associated with the development of BC, especially among cigarette smokers.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<i>Sulfotransferase</i> 1A1 G638A polymorphism, cigarette smoking and bladder cancer risk in Taiwan

Shen¹,

Wu²,

Wang³

et al. 2012

ABB

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“…A functional polymorphism in exon 7 of the SULT1A1 gene, with a G→A substitution, results in a change in the amino acid sequence from arginine to histidine, leading to a decrease in enzymatic activity and variable rates of activation or detoxification of procarcinogens (10,11). Carcinogenic aromatic amines, such as 4-aminobiphenyl, which is contained in tobacco smoke, are one of the causal factors of UC.…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of the association between sulfotransferase isoform 1A1 polymorphism and risk of urothelial carcinoma

Liu

Huang

et al. 2014

Molecular and Clinical Oncology

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Abstract. Sulfotransferase isoform 1A1 (SULT1A1) is a member of the sulfotransferase family that plays an important role in the biotransformation of numerous carcinogenic and mutagenic compounds through sulfation. A number of case-control studies were conducted to investigate the association between the Arg213His polymorphism in SULT1A1 and the risk of urothelial carcinoma (UC) in humans. However, the results were inconsistent. A meta-analysis based on 10 case-control studies was performed to address this issue. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of this association. Between-study heterogeneity was assessed with the Chi-square-based Q test. Overall, a possibly decreased risk of UC was associated with the SULT1A1 A/A polymorphism for the heterozygote model (OR=0.86, 95% CI: 0.76-0.98, P=0.471). In the subgroup analysis by cancer type, the results indicated that individuals with the G/G genotype had a significantly higher bladder cancer (BC) risk (GA vs. GG: OR=0.88, 95% CI: 0.74-0.99, P=0.626; GA/AA vs. GG: OR=0.85, 95% CI: 0.74-0.97, P=0.504), which was contrary to the results of the upper urinary tract urothelial carcinoma (UTUC) group (AA vs. GG: OR=2.18, 95% CI: 1.28-3.69; AA vs. GA/GG: OR=2.05, 95% CI: 1.24-3.38). In addition, stratification by smoking status demonstrated that the Arg213His polymorphism was associated with a decreased risk of UC in non-smokers (OR=0.70, 95% CI: 0.53-0.92) but not in smokers (OR=0.85, 95% CI: 0.70-1.03) under the dominant model. In conclusion, this meta-analysis demonstrated a significant association between the SULT1A1 Arg213His polymorphism and BC. However, there was insufficient evidence to support a consistent association between this polymorphism and UC, partly due to the differences between BC and UTUC.

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“…Cytosolic sulfotransferases (SULT) catalyze the conjugation of sulfo group to these substrates (6), the two major gene families being the phenol (SULT1A1) and hydroxysteroid (SULT2A) sulfotransferases. The SULT1A1 gene is located on chromosome 16p12.1-p11.2 and is expressed in several tissues including liver, lung, and kidney (6). A polymorphism (G!A) in exon 7 of the gene results in substitution of an arginine residue by histidine, decreased enzymatic activity, and changes in mutagen and procarcinogen detoxification and bioactivation rates (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

“…The SULT1A1 gene is located on chromosome 16p12.1-p11.2 and is expressed in several tissues including liver, lung, and kidney (6). A polymorphism (G!A) in exon 7 of the gene results in substitution of an arginine residue by histidine, decreased enzymatic activity, and changes in mutagen and procarcinogen detoxification and bioactivation rates (6)(7)(8). The variant allele SULT1A1*2 with reduced sulfotransferase activity might enhance the risk of cancer (6).…”

Section: Introductionmentioning

confidence: 99%

Phenol Sulfotransferase SULT1A12* Allele and Enhanced Risk of Upper Urinary Tract Urothelial Cell Carcinoma

Rouprêt¹,

Cancel‐Tassin²,

Compérat³

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Cytosolic sulfotransferases (SULT) are involved in detoxification pathways. A functional polymorphism in the SULT1A1 gene, leading to an Arg213His substitution (SULT1A1*2), is thought to confer susceptibility to various types of cancer. Upper urinary tract urothelial cell carcinomas (UUT-UCC) are rare (5% of all urothelial carcinomas). We genotyped 268 patients with UUT-UCC and 268 healthy controls matched for age, gender, tobacco consumption, and ethnicity. His213 (SULT1A1*2) allele frequency was significantly higher in patients than in controls (37.1% versus 28.9%; P = 0.004). The His/ His genotype corresponding to low-activity SULT1A1 enzyme conferred a significantly higher risk of UUT-UCC (odds ratio, 2.18; 95% confidence interval, 1.28-3.69; P = 0.004). (Cancer Epidemiol Biomarkers Prev 2007; 16(11):2500 -3)

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Genetic polymorphism in the sulfotransferase SULT1A1 gene in cancer

Cited by 17 publications

References 26 publications

<i>Sulfotransferase</i> 1A1 G638A polymorphism, cigarette smoking and bladder cancer risk in Taiwan

<i>Sulfotransferase</i> 1A1 G638A polymorphism, cigarette smoking and bladder cancer risk in Taiwan

Quantitative analysis of the association between sulfotransferase isoform 1A1 polymorphism and risk of urothelial carcinoma

Phenol Sulfotransferase SULT1A12* Allele and Enhanced Risk of Upper Urinary Tract Urothelial Cell Carcinoma

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Genetic polymorphism in the sulfotransferase SULT1A1 gene in cancer

Cited by 17 publications

References 26 publications

&lt;i&gt;Sulfotransferase&lt;/i&gt; 1A1 G638A polymorphism, cigarette smoking and bladder cancer risk in Taiwan

&lt;i&gt;Sulfotransferase&lt;/i&gt; 1A1 G638A polymorphism, cigarette smoking and bladder cancer risk in Taiwan

Quantitative analysis of the association between sulfotransferase isoform 1A1 polymorphism and risk of urothelial carcinoma

Phenol Sulfotransferase SULT1A1*2 Allele and Enhanced Risk of Upper Urinary Tract Urothelial Cell Carcinoma

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<i>Sulfotransferase</i> 1A1 G638A polymorphism, cigarette smoking and bladder cancer risk in Taiwan

<i>Sulfotransferase</i> 1A1 G638A polymorphism, cigarette smoking and bladder cancer risk in Taiwan

Phenol Sulfotransferase SULT1A12* Allele and Enhanced Risk of Upper Urinary Tract Urothelial Cell Carcinoma