Genetic polymorphism of calcium-sensing receptor in women with breast cancer

Abstract

Breast cancer is a disease of unknown etiology, whose major risk factors are genetic alterations. Polymorphism of the calcium-sensing receptor (CaSR) has been a focus of some recent studies, due to a probable association with breast cancer risk and tumor aggressiveness. A relationship between polymorphic rs17251221 variant of the CaSR gene, and allele G (considered a gain-of-function mutation) and breast cancer risk has been stressed, despite the paucity of studies found in the literature. The present study involved 137 women (69 women with breast cancer-case; and 68 controls without breast cancer) who had 3 ml of peripheral blood drawn for DNA study. Genomic DNA was extracted from leukocytes by genotyping technique with real-time polymerase chain reaction. The AG genotype (rs17251221) was present in 13 women (18.84%) from the case group and in 8 (11.76%) women from the control group (p = 0.3434), while the GG genotype (rs17251221) did not occur in any group. In contrast, no statistically significant difference was observed between the AG genotype of variant rs17251221 in premenopausal case and control women (p = 0.71). There was also no statistically significant difference between postmenopausal case and control patients (p = 0.6851). In the current study, CaSR gene polymorphism of SNP variant rs17251221 did not show any statistically significant association with breast cancer, in both premenopausal and postmenopausal women.

Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature

“…Breast cancer is a multifactorial disease of unknown etiology. One of the main risk factors is genetic alteration (5,6). Genetic mutations of breast cancer, BRCA 1 and 2, are related to the increased risk of developing hereditary breast and ovarian cancer over time (7).…”

“…Genetic mutations of breast cancer, BRCA 1 and 2, are related to the increased risk of developing hereditary breast and ovarian cancer over time (7). However, the involvement of genes in breast cancer has not yet been fully elucidated (5,6,8). Some authors have described a significant association between the levels of gene expression of CYP19A1 and breast cancer, however there is a need for further elucidation of the association between these levels and increased risk of breast cancer, survival, and disease progression (9)(10)(11).…”

Influence of Insulin-Like Growth Factor 1 Gene Expression in Women with Breast Cancer: A Systematic Review

“…For the year 2018, approximately 2.1 million new cases of breast cancer were estimated to occur worldwide [3]. Breast cancer is a complex disease of unknown and multifactorial etiology, in which one of the main risk factors is genetic alteration [4,5]. Thus, genetic mutations of breast cancer (BRCA) 1 and 2 genes are related to the increased risk of hereditary breast and ovarian cancer over time [6], however, the participation of genes in breast cancer has not yet been fully elucidated [4,5].…”

“…Breast cancer is a complex disease of unknown and multifactorial etiology, in which one of the main risk factors is genetic alteration [4,5]. Thus, genetic mutations of breast cancer (BRCA) 1 and 2 genes are related to the increased risk of hereditary breast and ovarian cancer over time [6], however, the participation of genes in breast cancer has not yet been fully elucidated [4,5]. Thus, changes in expression levels of the insulin-like growth factor 1 [IGF-1] gene have been evaluated in breast cancer, however, there is a need for further elucidation of the association between changes in IGF-1 levels and increase in the risk, survival, and disease progression of breast cancer [7,8].…”

“…The IGF system consists of two peptidic hormones (IGF-1 and IGF-2), two cell surface receptors (IGF-1R and IGF-2R), and at least six IGF-binding proteins [IGFBP [1][2][3][4][5][6]] that control normal growth and differentiation in most tissues [9,10]. The effects of free IGF-1 protein, which represent about 1% of the circulating proteins, are mediated by IGF-1R [11].…”