Genetic Polymorphism of Matrix Metalloproteinase-9 and Susceptibility to Myocardial Infarction: A Meta-Analysis

Abstract

Objective. Current findings on the association between MMP-9 rs3918242 and susceptibility to myocardial infarction (MI) are inconsistent, and their definite relationship is discussed in this meta-analysis. Methods. Eligible literatures reporting MMP-9 rs3918242 and susceptibility to MI were searched in PubMed, Cochrane Library, CNRI, and VIP using keywords such as “MMP-9”, “matrix metallopeptidase-9” and “myocardial infarction”, “acute myocardial infarction”, “AMI”, and “polymorphism”. Data from eligible literatures were extracted for calculating OR and corresponding 95% CI using RevMan 5.3 and STATA12.0. Results. Ten independent literatures reporting MMP-9 rs3918242 and susceptibility to MI were enrolled. Compared with subjects carrying CT&TT genotype of MMP-9 rs3918242, susceptibility to MI was lower in those carrying CC genotype ( OR = 1.49 , 95 % CI = 1.19 – 1.86 , P = 0.0004 ). Such a significance was observed in the overdominant ( OR = 1.27 , 95 % CI = 1.14 – 1.41 , P < 0.0001 ) and allele genetic models ( OR = 1.43 , 95 % CI = 1.17 – 1.74 , P = 0.0005 ) as well. This finding was also valid in the Asian population. Conclusions. Mutation on MMP-9 rs3918242 has a potential relevance with susceptibility to MI.

Bioinformatics analysis of potential common pathogenic mechanisms for systemic lupus erythematosus and acute myocardial infarction

“…53 MMP9 levels were significantly elevated in patients with STEMI, and a mutation on MMP-9 rs3918242 may be relevant to susceptibility to MI. 54,55 The ZFP36 family of highly conserved RNA-binding proteins, including ZFP36, ZFP36L1, and ZFP36L2, have been extensively studied in autoimmune diseases. While 28 single-nucleotide polymorphisms (SNPs) in the ZFP36 gene have been reported in patients with autoimmune diseases such as RA, psoriasis, multiple sclerosis (MS), and juvenile idiopathic arthritis (JIA), few studies have investigated the relationship between ZFP36 and SLE.…”

“…53 MMP9 levels were significantly elevated in patients with STEMI, and a mutation on MMP-9 rs3918242 may be relevant to susceptibility to MI. 54,55…”

Matrix Metalloproteinases in Cardioembolic Stroke: From Background to Complications

“…In patients without a metabolic syndrome, neither the T-allele occurrence nor MMP-9 activity were associated with the risk of an event [ 67 ]. The meta-analysis of literature concerning the association of MMP-9 rs3918242 SNP and susceptibility to MI revealed that carriers of CT and TT genotypes were less susceptible to MI in comparison with CC homozygotes [ 68 ]. As regards MMP-12 A/G polymorphism, carriers of G allele, which were characterized by lower MMP-12 promoter activity (-82AG and GG genotypes), had an increased risk of having MI and two or three vessel disease [ 56 , 69 ].…”

A Biopsychosocial Model Predicting Myocardial Infarction

“…A substantial body of knowledge related to its biological underpinnings has been accumulated. The intricate interplay of genetic predispositions, lipid profiles, inflammatory markers, hemodynamic factors, and the decline of sex hormones have been previously discussed [5][6][7][8]. Cardiovascular risk factors such as high blood pressure and dyslipidemia, among others, are considered in the development of myocardial infarction [5,6].…”

“…The intricate interplay of genetic predispositions, lipid profiles, inflammatory markers, hemodynamic factors, and the decline of sex hormones have been previously discussed [5][6][7][8]. Cardiovascular risk factors such as high blood pressure and dyslipidemia, among others, are considered in the development of myocardial infarction [5,6]. Age is an independent nonmodifiable cardiovascular risk factor that may be compounded by other additional modifiable factors, including frailty and diabetes, which are known to complicate and enhance cardiovascular risk factors associated with the onset of advanced age [6].…”