Genetic polymorphisms in cytochrome P450 (CYP) 1A1, CYP1A2, CYP2E1, glutathione S-transferase (GST) M1 and GSTT1 and susceptibility to prostate cancer in the Japanese population

Genetic polymorphisms in glutathione S-transferase T1 affect the surgical outcome of varicocelectomies in infertile patients

“…In this study, the genotype of each gene was not significantly related to this end-point (data not shown), possibly because the number of patients in this study was too small to elicit statistically significant results regarding the frequency of patients whose seminal findings increased into the WHO reference range. However, it is still important to note that varicocelectomy improves motile sperm concentrations, because this factor influences patients' decisions regarding assisted reproductive techniques [19][20][21][22][23][24][25][38][39][40][41]. In our series, the GSTM1-null, GSTT1-null, SOD2-Val/Val and NQO1-Ser/Ser genotypes were found in 52.7%, 49.8%, 83.2% and 17.8% of the controls, respectively, which are consistent with those observed earlier in Asian populations.…”

“…These polymorphisms of GSTs, SOD2 and NQO1 have been reported to influence individual susceptibility to various diseases, including malignancy [18][19][20][21][22][23][24][25], although the relationship between polymorphisms and male infertility remains to be elucidated [26,27]. We therefore speculated that individual susceptibility to varicocele-induced ROS may depend on one or more of these genetic polymorphisms and that the outcome of varicocelectomy may be influenced by an individual's genetic susceptibility to ROS.…”

Interacciones genéticas y genético-ambientales como efecto modificador del riesgo de cáncer de próstata: un diseño «case-only»

“…A la fecha en la literatura publicada no hemos encontrado diseños del tipo case-only para estos genotipos y su relación con cáncer de próstata. Murata y cols, en estudios (caso-control) realizados en población japonesa informaron de incrementos en el riesgo de CaP (OR 2,3 CI 95% 1,18-4,48; OR 2,2 CI 95% 1,12-4,20) cuando ambos polimorfismos genéticos estuvieron presentes (GSTM1 nulo y CYP1A1 m2) 39,40 . Por otro lado, diversos autores han evaluado polimorfismos genéticos combinados de GSTM1, GSTT1 y riesgo de CaP.…”

“…En cambio, los mismos autores no encontraron relación entre GSTM1 susceptible genotipo, hábito de fumar y riesgo de CaP. Similares hallazgos comunican Murata y cols 40 , quienes no observaron ningún efecto modificador en CaP cuando el hábito de fumar fue considerado. En general no existe clara evidencia epidemiológica que apoye una relación causal entre el hábito de fumar y riesgo de CaP 2,42,43 .…”

Genetic Polymorphisms of Glutathione S-transferase M1 and Prostate Cancer Risk in Asians: A Meta-analysis of 18 Studies

“…Of these studies, 9 reported on Caucasians, and 9 reported on East Asians. Studies were carried out in Japan (Murata et al, 2001;Nakazato et al, 2003;Komiya et al, 2005), China (Guan et al, 2005;Lai et al, 2005;Wang et al, 2005;Yang et al, 2006;Li et al, 2008), India ( Vijayalakshmi et al, 2005;Srivastava et al, 2005;Mittal et al, 2006;Thakur et al, 2011;Kumar et al, 2011), South Korea (Kwon et al, 2011), Iran (Ashtiani et al, 2011;Safarinejad et al, 2011) and Turkey (Aktas et al, 2004;Silig et al, 2006). A list of details abstracted from the studies included in the meta-analysis is provided through Table 1.…”