Genetic Polymorphisms in Estrogen-Related Genes and the Risk of Breast Cancer among Han Chinese Women

Sun, Ming; Du, Hongwu; Zhu, Anna; Lee, Hui; Garibay, Gorka Ruíz de; Li, Fenxia; Li, Ming; Yang, Xu

doi:10.3390/ijms16024121

Cited by 20 publications

(22 citation statements)

References 54 publications

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“…Chattopadhyay et al (2014) previously observed that rs700519 had a significant association with BC risk in North Indian women, which was strongly affected by menopausal status. Sun et al (2015) also reported that rs700519 is associated with susceptibility to BC among the Han Chinese population. However, Khvostova et al (2012) and Sangrajrang et al (2009) found that rs700519 was not associated with BC risk in Siberian and Thai women.…”

Section: Discussionmentioning

confidence: 93%

Genetic polymorphisms and haplotype of hormone-related genes are associated with the risk of breast cancer in Chinese women

Pan¹,

Song³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Sex hormones play important roles in breast cancer (BC) development. This study investigated associations between BC risk and hormone-related gene variants in Chinese women. In a cohort of 336 patients with histopathologically confirmed BC and 390 age-matched controls, we genotyped seven single nucleotide polymorphisms (SNPs) in five hormone-related genes: estrogen receptor-α (ESR1), aromatase (CYP19), catechol-O-methyl transferase (COMT), sex hormonebinding globulin (SHBG), and glutathione S-transferase (GSTP1). Among these seven SNPs, the SNPs in GSTP1 rs1695 [A/G; odds ratio (OR): 1.68; 95% confidence interval (CI): 1.23-2.30] and ESR1 rs2046210 (C/T; OR: 1.39; 95%CI = 1.02-1.91) were associated with an increased risk among heterozygote carriers. Homozygotes of minor alleles of CYP19 rs10046 (CC) were associated with a reduced risk of BC with OR: 0.61 (95%CI = 0.39-0.95). In addition, a stratified analysis by menopausal status indicated that the association of the CYP19 polymorphisms (rs10046 and rs700519) with BC risk was mainly evident in premenopausal women, and the association of CYP19 rs700519 with BC risk was significant in women less than 50 years old. Haplotype analysis identified 15 common haplotypes (>1%). The haplotype TGGGGTC was significantly associated with BC risk compared with the reference haplotype CGAGGTC (OR > 1000, P < 0.0001). Our data demonstrate that these ESR1, GSTP1, and CYP19 polymorphisms are associated with risk of BC, and the risk haplotype TGGGGTC could help to identify populations with high susceptibility to BC in Chinese women.

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Section: Discussionmentioning

confidence: 93%

Genetic polymorphisms and haplotype of hormone-related genes are associated with the risk of breast cancer in Chinese women

Pan¹,

Song³

et al. 2016

Genet. Mol. Res.

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“…CDX2, TBX21) (Tulsyan et al, 2014;Yu et al, 2014;Iqbal et al, 2015), estrogen-related enzymes or receptors (e.g. CYP1A2, CYP19A1, ESR1) (Son et al, 2015;Sun et al, 2015b) and cell surface glycoproteins, growth factors or their receptors (e.g. IGKC, CD44, VEGF, IGF1R, HGF, FGFR2, ESR1) (Choi et al, 2014;Pandey et al, 2014;Siddiqui et al, 2014;Wang et al, 2014c;Yu et al, 2014;Son et al, 2015).…”

Section: Vietnammentioning

confidence: 99%

A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors

Youn

Han

2020

Asian Pac J Cancer Prev

105

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Background and Aim: Breast cancer is the most prevalent cancer in women. To date, regional differences in breast cancer risk factors have not been identified. The aim of our review was to gain a better understanding of the role of risk factors in women with breast cancer in Asia. Methods: We conducted a PubMed search on 15 March 2016, for journal articles published in English between 2011 and 2016, which reported data for human subjects in Asia with a diagnosis of breast cancer. Search terms included breast neoplasm, epidemiology, Asia, prevalence, incidence, risk and cost of illness. Studies of any design were included, except for review articles and meta-analyses, which were excluded to avoid duplication of data. No exclusions were made based on breast cancer treatment. We reported the results using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Results: A total of 776 abstracts were retrieved. After screening against the eligibility criteria, 562 abstracts were excluded. The remaining 214 abstracts, which were published between 2013 and 2015, were included in this review. Results were summarized and reported under three categories: incidence, prevalence or outcomes for breast cancer in Asia; modifiable risk factors; and non-modifiable risk factors. We found that the increased risk of breast cancer among participants from Asia was associated with older age, family history of breast cancer, early menarche, late menopause, high body mass index, being obese or overweight, exposure to tobacco smoke, and high dietary intake of fats or fatty foods. In contrast, intake of dietary fruits, vegetables, and plant-and soy-based products was associated with a decreased breast cancer risk. While based on limited data, when compared to women from the United States, women from Asia had a decreased risk of breast cancer. Conclusions: This review of 214 abstracts of studies in Asia, published between 2013 and 2015, confirmed the relevance of known non-modifiable and modifiable risk factors for women with breast cancer.

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“…The same was reported among American CC homozygous women (Sigurdson, (Sun , et al;. On the contrary, a reverse association with the G; and not the C allele was observed among American women of African ethnicity (Van Emburgh, et al;.…”

Section: Discussion:-mentioning

confidence: 53%

Polymorphisms of Estrogen Biosynthesis and Metabolizing Genes in Egyptian Women With Breast Cancer.

Tolba¹,

Baz²,

Othman³

et al. 2017

IJAR

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Polymorphisms of genes responsible for biosynthesis and metabolism of estrogen including CYP and COMT groups might play a role in breast cancer. This study aims to investigate the association of CYP17 MspA1I, CYP1A1 MspI, CYP1B1 G>C, and COMT G>A polymorphisms with breast cancer in Egyptian women. Participants were in the form of 152 Egyptian women with cancer breast in addition to 100 healthy controls. They were subjected to DNA analysis using PCR-RFLP technique to characterize genetic polymorphisms of CYP17 MspA1I, CYP1A1 MspI, CYP1B1 G>C, and COMT G>A. Interestingly all these polymorphisms showed a positive association with cancer breast but in a variable degrees. Highest association was found with CYP1B1 C allele (p = 0.000, OR=10.26, 95% CI = 5.98 -17.8) followed by COMT A allele (p = 0.000, OR=6.66, 95% CI= 4.09 -10.9) then Cyp1A1 MspI C allele (p = 0.000, OR=4.46, 95% CI=2.68 -7.47) and lastly the CYP17 MspA1 C allele (p = 0.058, OR=1.46, 95% CI =1.0 -2.1). Regarding clinical presentation, COMT A allele carriage was significantly higher among cases with positive lymph nodes (p=0.02) and in pre-menopausal cases (p= 0.020) while CYP 17 MspA1I C allele carriage was significantly higher among cases with negative breast feeding (P= 0.043). We can come to a conclusion that rare alleles of estrogen biosynthesis and metabolizing genes particularly CYP1B1 G>C, and COMT G>A followed by CYP1A1 MspI, and CYP17 MspA1I are associated with breast cancer among Egyptian women.

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Genetic Polymorphisms in Estrogen-Related Genes and the Risk of Breast Cancer among Han Chinese Women

Cited by 20 publications

References 54 publications

Genetic polymorphisms and haplotype of hormone-related genes are associated with the risk of breast cancer in Chinese women

Genetic polymorphisms and haplotype of hormone-related genes are associated with the risk of breast cancer in Chinese women

A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors

Polymorphisms of Estrogen Biosynthesis and Metabolizing Genes in Egyptian Women With Breast Cancer.

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