Genetic Polymorphisms inPRM1,PRM2, andYBX2Genes are Associated with Male Factor Infertility

Abstract

This study demonstrates that the PRM1 c.-190C>A polymorphism is associated with sperm DNA fragmentation, which may impact male infertility in the Turkish population. Further research with larger groups and in various other study populations will be required to clarify the impact of protamine and YBX2 gene polymorphisms on male infertility.

Evaluation of the association between polymorphisms of PRM1 and PRM2 and the risk of male infertility: a systematic review, meta-analysis, and meta-regression

“…Table 1 presentations the features of studies entered to the meta-analysis. The studies [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] were published from 2003 to 2019. Twelve studies 23,[26][27][28][29][30][31]33,35,[37][38][39] were reported in Caucasian, four studies 24,32,34,36 in Asian, and one 25 in mixed ethnicities.…”

“…The studies [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] were published from 2003 to 2019. Twelve studies 23,[26][27][28][29][30][31]33,35,[37][38][39] were reported in Caucasian, four studies 24,32,34,36 in Asian, and one 25 in mixed ethnicities. The genotyping method was PCR-based in fourteen studies [23][24][25][26][27][28][29][30][31]33,35,[37][38][39] and Mass ARRAY in three studies 32,34,36…”

“…Twelve studies 23,[26][27][28][29][30][31]33,35,[37][38][39] were reported in Caucasian, four studies 24,32,34,36 in Asian, and one 25 in mixed ethnicities. The genotyping method was PCR-based in fourteen studies [23][24][25][26][27][28][29][30][31]33,35,[37][38][39] and Mass ARRAY in three studies 32,34,36 . The source of controls was hospital-based in ten studies 25,[31][32][33]33,34,[36][37][38][39] and populationbased in seven studies 24,[26][27][28][29][30]…”

“…The genotyping method was PCR-based in fourteen studies [23][24][25][26][27][28][29][30][31]33,35,[37][38][39] and Mass ARRAY in three studies 32,34,36 . The source of controls was hospital-based in ten studies 25,[31][32][33]33,34,[36][37][38][39] and populationbased in seven studies 24,[26][27][28][29][30]35 . Tables 2 and 3 show the prevalence of the genotypes and alleles of PRM1 and PRM2 polymorphisms.…”

The c.‐190 C>A transversion in promoter region of protamine 1 gene as a genetic risk factor in Egyptian men with idiopathic infertility

“…Aydos et al () studied the genetic polymorphisms in PRM1, PRM2 and YBX2 genes and their association with male infertility. Their results agreed with the present study as the AA and CA genotypes of the PRM1 c.‐190 C>A polymorphism had a significant association with infertility ( p < 0.001), and the AA genotype was significantly associated with high sperm DNA damage ( p < 0.001).…”