Genetic Polymorphisms in SOD (rs2070424, rs7880) and CAT (rs7943316, rs1001179) Enzymes Are Associated with Increased Body Fat Percentage and Visceral Fat in an Obese Population from Central Mexico

Hernández‐Guerrero, César; Hernández-Chávez, Paulina; Romo-Palafox, Inés; Blanco-Melo, Grecia; Parra-Carriedo, Alicia; Pérez-Lizaur, Ana Bertha

doi:10.1016/j.arcmed.2016.08.007

Cited by 25 publications

(19 citation statements)

References 34 publications

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“…It would be interesting to more precisely determine the mechanistic link; doing so may enable clinicians to predict the efficacy of liraglutide treatment based on genotype. SNPs close to antioxidant genes producing super oxide dismutase and catalase have also been associated with body fat distribution, and obese carriers of two distinct SNPs had more abdominal VAT accumulation compared to obese non-carriers, further supporting a role for genetic regulation of abdominal VAT at the level of the adipose tissue (107). Additionally, four SNPs -rs2070424, rs7880, rs7943316, rs21001179 -were also shown to be associated with greater abdominal VAT volumes (107).…”

Section: Meta-analyses Published By the Genetic Investigation Of Anthmentioning

confidence: 90%

Determinants of body fat distribution in humans may provide insight about obesity-related health risks

Frank

Santos

Palmer

et al. 2019

Journal of Lipid Research

181

133

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Section: Meta-analyses Published By the Genetic Investigation Of Anthmentioning

confidence: 90%

Determinants of body fat distribution in humans may provide insight about obesity-related health risks

Frank

Santos

Palmer

et al. 2019

Journal of Lipid Research

181

133

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“…The conditions, primers sequences, and identification of WT and mutated alleles of the five genetic polymorphisms have been described previously [ 26 , 27 ].…”

Section: Methodsmentioning

confidence: 99%

“…Our research group previously identified an association with obesity for the SNPs 599C>T GPX1 (rs1050450) and − 251A>G SOD1 (rs2070424). For the SNPs − 21A>T CAT (rs7943316), − 262C>T CAT (rs1001179), and 47C>T SOD2 (rs4880), we identified differences between people with obesity CR (homozygous plus heterozygous) of mutated allele, and obese WT people, with respect to anthropometric and clinical variables in a cross-sectional study [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms of antioxidant enzymes CAT and SOD affect the outcome of clinical, biochemical, and anthropometric variables in people with obesity under a dietary intervention

et al. 2018

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BackgroundGenetic polymorphisms of antioxidant enzymes CAT, GPX, and SOD are involved in the etiology of obesity and its principal comorbidities. The aim of the present study was to analyze the effect of aforementioned SNPs over the output of several variables in people with obesity after a nutritional intervention. The study included 92 Mexican women, which received a dietary intervention by 3 months. Participants were genotyped and stratified into two groups: (1) carriers; mutated homozygous plus heterozygous (CR) and (2) homozygous wild type (WT). A comparison between CR and WT was done in clinical (CV), biochemical (BV), and anthropometric variables (AV), at the beginning and at the end of the intervention.ResultsParticipants (n = 92) showed statistically significant differences (p < 0.05) at the end of the nutritional intervention in several CV, BV, and AV. However, two kinds of responses were observed after genotyping participants: (A) CR and WT showed statistically significant differences (p < 0.05) in several CV, BV, and AV for the SNPs 599C>T GPX1 (rs1050450), − 251A>G SOD1 (rs2070424), and − 262C>T CAT (rs1001179). (B) Only CR showed statistically changes (p < 0.05) in several CV, BV, and AV for the SNPs − 21A>T CAT (rs7943316) and 47C>T SOD2 (rs4880). The dietary intervention effect was statistically significantly between the polymorphisms of 47C>T SOD2 and BMI, SBP, TBARS, total cholesterol, and C-LCL (p < 0.05) and between the polymorphisms of − 21A>T CAT (rs7943316) and SBP, DBP, total cholesterol, and atherogenic index (p < 0.05).ConclusionPeople with obesity display different response in several CV, BV, and AV after a nutritional intervention, depending on the antioxidant genetic background of SOD and CAT enzymes.

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“…Patients with BMI over 50 showed a dramatical decrease in Cu,Zn‐SOD activity, reaching 853 ± 30 U/g Hb . It has recently been observed, in Mexican population, that increased body fat is more popular among individuals with GA and GG genotype of SOD1 rs2070424 . Genotypes were detected with use of PCR‐RFLP method.…”

Section: Obesity Is Associated With Changes In Cuzn‐sod Activitymentioning

confidence: 97%

The copper‐zinc superoxide dismutase activity in selected diseases

Lewandowski

Kępińska

Milnerowicz

2018

Eur J Clin Investigation

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Copper‐zinc superoxide dismutase (Cu,Zn‐SOD) plays a protective role in various types of tissue protecting them from oxidative damage. Alterations in Cu,Zn‐SOD (SOD1 and SOD3) activity and its expression have been observed in pathological occurrences most prevalent in modern society, including inflammatory bowel disease, obesity and its implications—diabetes and hypertension, and chronic obstructive pulmonary disease. Moreover, several SOD1 and SOD3 gene polymorphisms have been associated with the risk of developing a particular type of disease, or its exacerbation. This article features recent observations in this topic, aiming to show the importance of proper gene sequence and activity of Cu,Zn‐SOD in the aforementioned diseases.

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Genetic Polymorphisms in SOD (rs2070424, rs7880) and CAT (rs7943316, rs1001179) Enzymes Are Associated with Increased Body Fat Percentage and Visceral Fat in an Obese Population from Central Mexico

Cited by 25 publications

References 34 publications

Determinants of body fat distribution in humans may provide insight about obesity-related health risks

Determinants of body fat distribution in humans may provide insight about obesity-related health risks

Genetic polymorphisms of antioxidant enzymes CAT and SOD affect the outcome of clinical, biochemical, and anthropometric variables in people with obesity under a dietary intervention

The copper‐zinc superoxide dismutase activity in selected diseases

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