Genetic Polymorphisms ofIL1B, IL6,andTNFαin a Chinese Han Population with Pulmonary Tuberculosis

Abstract

Background The factors that predispose to pulmonary tuberculosis (PTB) are not fully understood. Previous studies have shown that cytokine gene polymorphisms were associated with PTB. Objectives In this study, we have investigated the relationship between ILB, IL6, and TNFα polymorphisms and a predisposition to Mycobacterium tuberculosis (MTB) infection and PTB. Methods A total of 209 cases of PTB, 201 subjects with latent TB infection (LTBI), and 204 healthy controls (HCS) were included in this study. Logistic regression analyses under allelic, homozygous, and heterozygous models were used to calculate P values, odds ratios (ORs), and 95% confidence intervals (CIs) for assessing the association between single nucleotide polymorphisms (SNPs) and disease risk, adjusting for sex and age. Genotyping was conducted using the improved multiplex ligase detection reaction (iMLDR) method. Results When comparing PTB patients with LTBI subjects, significant associations with disease development were observed for SNPs of IL6 and TNFα. When comparing LTBI subjects with HCS, IL1B polymorphisms were significantly associated with LIBI. Haplotype analyses suggested that the CGG haplotype of IL1B was associated with an increased risk of PTB (P = 0.039, OR = 1.34, 95% CI: 1.01–1.76), while the TTGCG haplotype of TNFα was a protective factor against PTB (P = 0.039, OR = 0.66, 95% CI: 0.44–0.98). Conclusion Our study demonstrated that IL1B variants were related to LTBI and IL6 and TNFα variants were associated with PTB.

The Association of Cytokine Genes Polymorphisms (IL1β+3954 C/T, IL18-137 G/C, and IL18-607 C/A) in Type 2 Diabetes Mellitus-tuberculosis

“…In this current study showed that no association between genotypes and alleles of IL1β+3954 C/T, IL18-137 G/C, and IL18-607 C/A gene polymorphism with T2DM-TB compared to control group and T2DM-TB compared to T2DM group. The association of IL1β+3954 C/T gene polymorphism with TB and latent TB has been reported in the literature before, with a different result [9], [18], [19], [20], but the associations of IL1β+3954 C/T gene polymorphism with T2DM-TB have not reported.…”

Association of human leukocyte antigens‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population

“…Multivariable logistic analysis revealed the association between rs7453920 GA genotype and an increased risk of TB. As mentioned in the literature, GA genotype of SNP rs2069837 A>G located within IL‐6 was associated with PTB, while GG genotype did not show any association with TB (Wu et al, ). Prior studies have noted the relationship between CT genotype of TNF‐857 and spinal TB, while TT genotype did not correlate with spinal TB (Zheng et al, ).…”

The Gene Polymorphisms (-308G/A) and the Tumor Necrosis Factor-alpha Levels in Type 2 Diabetic Patients with and Without Tuberculosis Infection

“…Another study showed that A allele of TNF-α at position (-308) was associated with tuberculosis infection [12]. Wu et al, (2017) notice that TNF-α gene polymorphism (-308G/A) was associated with severity of tuberculosis infection in a Chinese Han Population [23]. In this context, previous study showed that the GG wild type genotype significantly decreased in diabetic patients and also in tuberculosis patients compared to healthy subjects, different with our study that found the GG genotype frequency was highest in all groups.…”