Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3′-UTR, influence susceptibility to gastric cancer

Arisawa, Tomiyasu; Tahara, Tomomitsu; Shiroeda, Hisakazu; Matsue, Yasuhito; Minato, Takahiro; Nomura, Tomoe; Yamada, Hideto; Hayashi, Ranji; Saito, Takashi; Matsunaga, Kazuhiro; Fukuyama, Tomoki; Hayashi, Nobuhiko; Otsuka, Toshimi; Fukumura, Atsushi; Nakamura, Masakatsu; Shibata, Tomoyuki

doi:10.1016/j.humimm.2012.04.011

Cited by 64 publications

(35 citation statements)

References 28 publications

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“…IL-17A and IL-17F are important members of the IL-17 cytokine family preferentially produced by helper T 17 (Th17) cells, which are responsible for the pathogenic activity of the lineage of CD4+ effector cells and multiple proinflammatory mediators (Rutitzky et al, 2005;Ishigame et al, 2009 et al, 2010). However, subsequent replication studies for the association between IL-17A and IL-17F variants and gastric cancer risk are controversial (Shibata et al, 2009;Arisawa et al, 2012;Rafiei et al, 2013;Zhang et al, 2014;Zhu et al, 2014). The discrepancy may be attributed to the relatively small sample size of previous studies and the genetic heterogeneity of polymorphisms in gastric cancer among different populations.…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of Associations between Interleukin-17 Gene Polymorphisms and Risk of Gastric Cancer

Sun

Liu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Previous studies have indicated that single nucleotide polymorphisms (SNPs) of the interleukin-17 (IL-17) gene are associated with an increased risk of gastric cancer. However, the findings were inconsistent. Materials and Methods: To provide a more reliable estimation of the association between SNPs in the IL-17 gene and the susceptibility to gastric cancer, we searched PubMed, CNKI, and Wan Fang databases and selected finally six studies covering 2,366 cases and 3,205 controls to perform a meta-analysis. Results: Statistical analyses showed that an rs2275913 polymorphism within the IL-17A gene was significantly associated with an increased risk of gastric cancer using a generalized odds ratio (ORG, a model-free approach). Moreover, we also found that the 'A' allele carriers of IL-17A rs2275913 had a significant link with clinicopathological features. However, no significant positive signals were observed in the association analysis of the rs3748067 and rs763780 polymorphisms with the risk of gastric cancer in IL-17A and IL-17F, respectively. Conclusions: Despite some limitations, the present meta-analysis provided a more precise estimation of the relationship between the IL-17 gene SNPs and gastric cancer risk compared with individual studies.

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Section: Introductionmentioning

confidence: 99%

Meta-analysis of Associations between Interleukin-17 Gene Polymorphisms and Risk of Gastric Cancer

Sun

Liu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…For the correlation between the IL-17 rs2275913 genetic variation and gastric cancer risk, several studies were performed in different populations and reported different results (Shibata et al, 2009;Arisawa et al, 2012;Qinghai et al, 2014;Wang et al, 2014;Zhang et al, 2014;Hou and Yang, 2015). Shibata et al (2009), Arisawa et al (2012 and Zhang et al (2014) conducted studies in Japanese and Chinese populations, and they revealed that the IL-17 rs2275913 genetic variation was significantly associated with a higher risk of gastric cancer when compared to the wild-type genotype.…”

Section: Discussionmentioning

confidence: 99%

IL-17 rs2275913 genetic variation contributes to the development of gastric cancer in a Chinese population

Dong

et al. 2016

Genet. Mol. Res.

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ABSTRACT. The purpose of this hospital-based case-control study was to assess whether the interleukin (IL)-17 rs2275913 genetic variation can influence susceptibility to gastric cancer. Samples from a total of 202 gastric cancer patients and 237 controls were collected from the Linyi People's Hospital between March 2013 and March 2015. The IL-17 rs2275913 gene polymorphism was identified by polymerase chain reaction and restriction fragment length polymorphism. When compared with control subjects, gastric cancer patients were older in age (OR = 3.89, 95%CI = 2.55-5.95), male (OR = 2.08, 95%CI = 1.39-3.10), had a habit of alcohol consumption (OR = 1.71, 95%CI = 1.15-2.55), and were more likely to be infected with Helicobacter pylori (OR = 2.76, 95%CI = 1.83-4.16). We observed that the AA genotype of the IL-17 rs2275913 polymorphism resulted in a 2.32-fold risk of gastric cancer compared to the GG genotype (OR = 2.32, 95%CI = 1.20-4.54; P = 0.01). The AG combined with AA genotype of the IL-17 rs2275913 polymorphism had more risk of developing gastric cancer than the GG genotype (OR = 1.50, 95%CI = 1.01-2.23; P = 0.04). Moreover, the AA genotype of the IL-17 rs2275913 polymorphism was correlated with a higher risk of developing gastric cancer than the GG and AG genotypes combined (OR = 2.01, 95%CI = 1.08-3.79; P = 0.02). In conclusion, the results of our study suggest that the IL-17 rs2275913 polymorphism could contribute to the risk of gastric cancer.

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“…Genetic origin of cancer had been a focus of research in the past years, and some studies found that the genetic alteration was associated with the susceptibility of cancer and might become an early diagnosis indicator to predict the risk of cancer (Sagae et al, 2002;Huo et al, 2009;Jeon et al, 2010;Arisawa et al, 2012;. Prohibitin, acting as a tumor suppression gene, might play an important role in the pathogenesis of cancer.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between the Prohibitin 3' Untranslated Region C > T Gene Polymorphism and Cancer Susceptibility - Results of a Meta-analysis

Zhou

Yin²,

Huang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3′-UTR, influence susceptibility to gastric cancer

Cited by 64 publications

References 28 publications

Meta-analysis of Associations between Interleukin-17 Gene Polymorphisms and Risk of Gastric Cancer

Meta-analysis of Associations between Interleukin-17 Gene Polymorphisms and Risk of Gastric Cancer

IL-17 rs2275913 genetic variation contributes to the development of gastric cancer in a Chinese population

Relationship Between the Prohibitin 3' Untranslated Region C > T Gene Polymorphism and Cancer Susceptibility - Results of a Meta-analysis

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