Genetic polymorphisms of MBL2 and tuberculosis susceptibility: a meta-analysis of 22 case-control studies

Abstract

IntroductionThe association of mannose-binding lectin gene (MBL2) polymorphisms with tuberculosis susceptibility was inconclusive. In this study, a meta-analysis of 22 case-control studies was carried out to assess the effect of MBL2 polymorphisms on tuberculosis risk.Material and methodsA search was performed in Embase, PubMed and Web of Science up to Sep 30, 2015. Odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the association. Statistical analyses were performed using STATA 12.0 software.Resultsrs1800451 was associated with a decreased tuberculosis risk in the allele model (C vs. A: OR = 0.93, 95% CI: 0.86–1.00, p = 0.050). In analyses stratified by ethnicity, rs7096206 (C/G: OR = 1.31, 95% CI: 1.10–1.57, p = 0.003; GG vs. GC + CC: OR = 0.69, 95% CI: 0.56–0.85, p < 0.001) and A/O (O/A: OR = 1.34, 95% CI: 1.10–1.64, p = 0.004) were associated with tuberculosis risk in Asians, A/O (AA vs. AO + OO: OR = 0.71, 95% CI: 0.51–0.99, p = 0.041) and rs1800451 (AC vs. AA + CC: OR = 2.70, 95% CI: 1.27–5.74, p = 0.010) were associated with tuberculosis risk in Americans, and rs1800451 (C/A: OR = 0.92, 95% CI: 0.86–0.99, p = 0.035) was associated with tuberculosis risk in Africans. Additionally, rs1800450 (B/A: OR = 0.42, 95% CI: 0.25–0.72, p = 0.001) was associated with tuberculosis risk in Europeans.ConclusionsThe MBL2 rs1800451 polymorphism is associated with decreased TB risk in the general population, and A/O, rs7096206, rs1800450 and rs1800451 are likely to be associated with the risk for some specific ethnic groups.

Association between polymorphisms in mannose-binding lectin 2 gene with pulmonary tuberculosis susceptibility

“…Cao et al analyzed 22 studies to assess the effect of MBL2 polymorphisms on TB risk. The rs1800451 polymorphism was associated with decreased TB risk in both the total sample and in some ethnic groups; in addition, A/O, rs7096206 and rs1800450 were likely only related to risk in some ethnic groups [56]. The analysis did not differentiate between the total sample and PTB subgroups.…”

Mannose-binding lectin 2 gene polymorphisms and their association with tuberculosis in a Chinese population

“…To our knowledge, this is the first study to report that the rs930507, rs2099902, and rs10824793 polymorphisms can affect TB development in a population of Han Chinese origin. It is worth mentioning that several meta-analysis studies have reported that five MBL2 SNPs (rs1800450, rs1800451, rs5030737, rs7095891, and rs7096206) are associated with an increased or decreased TB risk [22][23][24][25][26]. However, there is insufficient data regarding the role of rs930507, rs2099902, and rs10824793 in TB susceptibility.…”

The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System

“…As revealed in several meta-analyses, the role of MBL in that disease is unclear and inconsistent, apparently reflecting differences in study design, ethnicity and number of patients tested. Although it is generally believed that MBL2 O alleles may contribute to enhanced susceptibility to TB, at least in some populations (87)(88)(89), certain data suggest diverse associations for D, B, and C variants. Tong et al (90) concluded that minor alleles in codons 52 (D) and 54 (B) elevate the risk of developing disease while that in codon 57 (C) has a protective effect (in Chinese population).…”