Genetic predisposition for atopy and allergic rhinitis in the Singapore Chinese population

Wang, De Yun

doi:10.5415/apallergy.2011.1.3.152

Cited by 16 publications

(8 citation statements)

References 26 publications

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“…The scope of this study was beyond a genetic investigation. However, many of the gene-based AR studies revealed no significant association with AR [51]. Allergic and non-allergic rhinitis are both similar in signs and symptoms, except that non-allergic rhinitis don’t involve the immune system.…”

Section: Discussionmentioning

confidence: 99%

Allergic rhinitis: Disease characteristics and coping measures in Saudi Arabia

et al. 2019

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Background Despite allergic rhinitis (AR) being a highly prevalent disease, according to literature, it is often underdiagnosed or undertreated. Aim This study explored the disease characteristics of AR in the Saudi community and the non-conventional coping measures used to alleviate symptoms. Methods The study was a nationwide cross-sectional study, using a self-report electronic survey distributed via social media networks in 2018. The survey included an explanatory letter and consent. The sample size comprised 3,458 participants and 2,849 adults had at least one of the four signs of AR, i.e. watery-nose, sneezing, nasal obstruction, itchy nose, watery eyes, in the past year, not related to cold/flu. The outcomes of the study were the triggers, pattern, severity and the classification of AR (2016 ARIA guidelines) and coping measures. Descriptive statistics, univariate analytic statistics and binary logistic regression analyses were conducted. The P-value was considered statistically significant at <0.05. Results The leading reported trigger of AR was dust (74%, n = 2118), followed by pollen (17%, n = 477), mold (5%, n = 140) and fur (4%, n = 114). The prevalence of intermittent AR was (54%, n = 1,635), while that of persistent AR was (46%, n = 1,314). Almost one-third (34%, n = 959) complained of mild forms of AR, while others complained of moderate to severe forms (66%, n = 1890). The coping measures were mainly shower/humidification 368(12.9%) and herbal hot drinks 266(9.3%). Older participants (adj.OR = 1.3[1.1–1.5]) and overweight participants, (adj.OR = 1.2[1.1–1.4]) reported more persistent forms of rhinitis compared to their counter groups, (adj.P<0.001 and adj.P = 0.032) respectively. Female participants (adj.OR = 0.8[0.7–0.9]) had significantly milder forms of AR, in comparison to males, adj.P = 0.006. Conclusion This study presented the disease characteristics of self-reported AR and its associated factors in Saudi Arabia. Special attention should be paid to older age groups and overweight patients who reported persistent forms of AR. Males reported more severe and persistent forms of AR.

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Section: Discussionmentioning

confidence: 99%

Allergic rhinitis: Disease characteristics and coping measures in Saudi Arabia

et al. 2019

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“…The pathogenesis of AR and similar allergic diseases involves complex interactions of environmental exposure to allergens and respiratory irritants (Shusterman et al, 2003;Wang, 2005;Bousquet, 2008) as well as genetic predisposition of the individual patients (Dávila et al, 2009). Many susceptibility loci for AR and atopy have been described in various Western and Eastern populations (Bauchau and Durham, 2004;Mou et al, 2010;Wang, 2011). Results from several studies have suggested that interactions of multiple genes and environmental factors cause susceptibility to AR.…”

Section: Introductionmentioning

confidence: 97%

Investigation of Poly (ADP-Ribose) Polymerase-1 Genetic Variants as a Possible Risk for Allergic Rhinitis

Özaydın

AkbasFahri

AksoyFadlullah

et al. 2014

Genetic Testing and Molecular Biomarkers

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Recent studies point toward the involvement of poly (ADP-ribose) polymerase-1 (PARP-1) in the pathogenesis of allergic airway inflammation, such as asthma and allergic rhinitis (AR). It has been suggested that inhibition of PARP-1 provides significant protection against systemic or tissue inflammation in animal models. The objective of this study was to investigate whether single-nucleotide polymorphisms of PARP-1 gene are associated with genetic susceptibility to AR. We studied the effect of promoter variations and Val762Ala polymorphism of the PARP-1 gene on the risk for developing AR in a case-control association study with 110 RA patients and 130 control subjects in a Turkish population. The polymorphisms of 410 C/T, -1672G/A, and Val762Ala in the PARP-1 gene were analyzed using the polymerase chain reaction-restriction fragment length polymorphism method. Haplotype analysis of these groups was also performed. The results were statistically analyzed by calculating the odds ratio (OR) and their 95% confidence intervals using χ(2) tests. The heterozygote genotype of the promoter polymorphism (-1672) was significantly found to be associated with susceptibility to AR (OR: 0.56) among the tested single-nucleotide polymorphisms. Haplotypes of PARP-1 -410, -1672, and 762 were not associated with an increased risk for AR. These results raise the possibility that the promoter (-1672) polymorphism of the PARP-1 gene may be a risk factor for AR.

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“…24,25,28 Actually, it was reasonable that the results from epidemiologic studies were not consistent with the results from respective functional study. This is because AR is a complex atopic disorder and is affected by many factors including both genetic and environmental factors, and different genetic backgrounds including age or ethnicity may lead to different outcomes 38,39 and other undiscovered genes involved in AR development might mask the influence of the D or I allele.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme insertion/deletion polymorphism associated with allergic rhinitis susceptibility: Evidence from 1410 subjects

Lin

Zheng

2013

J Renin Angiotensin Aldosterone Syst

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Background and objective: Whether the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene increases susceptibility to allergic rhinitis (AR) is still undetermined. Therefore, this meta-analysis was performed to systematically assess the possible association between them. Methods: The OVID, Medline, Embase, Web of Science, CNKI and Wangfang databases were searched to identify the eligible studies focusing on the association between ACE I/D polymorphism and susceptibility to AR. Results: A total of 1410 subjects from six studies were subjected to meta-analysis. In the overall analysis, ACE I/D polymorphism had a statistically significant association with increased AR risk under all genetic models (p<0.05). In the subgroup analysis by ethnicity, significant elevated AR risks were associated with ACE I/D polymorphism in Asians under all genetic models (p<0.05) and in Caucasians under under allele contrast, homozygous comparison and recessive models (p<0.05). In the subgroup analysis by age, ACE I/D polymorphism was associated with significant elevated risks of AR in adults (p<0.05) but not in children (p>0.05) under all genetic models. Conclusions:The ACE I/D polymorphism may be a risk factor for AR and studies with large sample size and representative population are warranted to verify this finding.

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Genetic predisposition for atopy and allergic rhinitis in the Singapore Chinese population

Cited by 16 publications

References 26 publications

Allergic rhinitis: Disease characteristics and coping measures in Saudi Arabia

Allergic rhinitis: Disease characteristics and coping measures in Saudi Arabia

Investigation of Poly (ADP-Ribose) Polymerase-1 Genetic Variants as a Possible Risk for Allergic Rhinitis

Angiotensin-converting enzyme insertion/deletion polymorphism associated with allergic rhinitis susceptibility: Evidence from 1410 subjects

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