Genetic predisposition to gestational diabetes mellitus in the Kazakh population

Svyatova, Gulnara; Berezina, Galina; Danyarova, Laura; Kuanyshbekova, Roza; Urazbayeva, Gulfairuz

doi:10.1016/j.dsx.2022.102675

Diabetes & Metabolic Syndrome: Clinical Research & Revi

2022

DOI: 10.1016/j.dsx.2022.102675

|View full text |Cite

Genetic predisposition to gestational diabetes mellitus in the Kazakh population

Gulnara Svyatova¹,

Galina Berezina²,

Laura Danyarova³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Genetic Predisposition to Prediabetes in the Kazakh Population

Svyatova,

Berezina,

Murtazaliyeva

et al. 2024

CIMB

View full text Add to dashboard Cite

The aim of this study was to conduct a comparative analysis of the population frequencies of the minor allele of polymorphic variants in the genes TCF7L2 (rs7903146) and PPARG (rs1801282), based on the genome-wide association studies analysis data associated with the risk of developing prediabetes, in an ethnically homogeneous Kazakh population compared to previously studied populations worldwide. This study utilized a genomic database consisting of 1800 ethnically Kazakh individuals who were considered in healthy condition. Whole-genome genotyping was performed using Illumina OmniChip 2.5–8 arrays, which interrogated approximately 2.5 million single nucleotide polymorphisms. The distribution of genotypes for the TCF7L2 (rs7903146) and PPARG (rs1801282) polymorphisms in the Kazakh sample was found to be in Hardy–Weinberg equilibrium (p > 0.05). The minor G allele of the “Asian” protective polymorphism rs1801282 in the PPARG gene was observed at a frequency of 13.8% in the Kazakh population. This suggests a potentially more significant protective effect of this polymorphism in reducing the risk of prediabetes among Kazakhs. The frequency of the unfavorable T allele of the insulin secretion-disrupting gene TCF7L2 (rs7903146) in Kazakhs was 15.2%. Studying the associations of genetic markers for prediabetes enables the timely identification of “high-risk groups” and facilitates the implementation of effective preventive measures. Further results from replicative genomic research will help identify significant polymorphic variants of genes underlying the alteration of prediabetes status.

show abstract

Genetic Predisposition to Prediabetes in the Kazakh Population

Svyatova,

Berezina,

Murtazaliyeva

et al. 2024

CIMB

View full text Add to dashboard Cite

show abstract

Set of heart failure early mortality prevention methods

Serzysko,

Mroczkowska,

Podsiadlo

et al. 2024

Healthc Low-resour S

View full text Add to dashboard Cite

Heart failure is a common chronic disease with a poor prognosis that often ends in death. The research thus aims to thoroughly investigate ways in which the prognosis of heart failure could be improved. For this purpose, a 9-month study was conducted with a group of people who followed the Mediterranean diet, and the effects of this diet on the cardiovascular system and the state of the body as a whole were assessed. The study found that adherence to the principles of the Mediterranean diet improved the quality of life of patients, according to the quality-of-life questionnaire (the average score was 81.3 at the beginning of the study and 87 points at the end of the study), and the level of adherence to the Mediterranean diet in the study group increased from 30 points to 39.7, according to the MedDietScore (MDS) scale. There was also an improvement in appetite and sleep quality. A decrease in the average blood pressure in the group was recorded (from 140/95 to 137/88 mmHg). It was found that due to proper nutrition, the participant’s Body Mass Index (BMI) was reduced (from 31.2 kg/m2 to 29.6 kg/m2), and the percentage of overweight people in the study group was also reduced from 44% to 26%. It was noted that no deterioration in heart failure class or functional class was recorded during the study. The left ventricular ejection fraction remained unchanged.

show abstract

Evaluation of the therapeutic potential and safety of Al Hayat black cumin seed oil: an observational study

Turabekov

2024

Healthc Low-resour S

View full text Add to dashboard Cite

The purpose of this study was to investigate the therapeutic potential and safety of the use of Al Hayat black cumin seed oil. Descriptive and discrete statistical methods and frequency analysis were applied. There were 20 participants in total aged between 11 and 67 years, both men and women. The participants were divided into three subgroups, each receiving different doses of black cumin oil: 10 mg/kg, 20 mg/kg, and 30 mg/kg, respectively. Such parameters as general blood count, liver enzyme activities (aspartate aminotransferase and alanine aminotransferase), creatinine, and serum iron levels were analysed. A dose of 10 mg/kg was found to have no significant therapeutic or adverse effect. A dosage of 20 mg/kg demonstrated positive effects on platelet, immune cell, and creatinine values with no significant side effects. A dose of 30 mg/kg is not recommended for use due to the high risk of adverse reactions. The author also found no significant differences in the therapeutic effects and adverse reactions to black cumin oil that could be related to the gender or age of the participants.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Genetic predisposition to gestational diabetes mellitus in the Kazakh population

Cited by 3 publications

References 31 publications

Genetic Predisposition to Prediabetes in the Kazakh Population

Genetic Predisposition to Prediabetes in the Kazakh Population

Set of heart failure early mortality prevention methods

Evaluation of the therapeutic potential and safety of Al Hayat black cumin seed oil: an observational study

Contact Info

Product

Resources

About