Genetic predisposition to ocular melanoma

Association of first ocular melanoma with subsequent cutaneous melanoma: Results from the Swedish Family‐Cancer Database

“…1,2 The incidence of OM has remained constant in Sweden, which is in sharp contrast to the incidence of cutaneous melanoma (CM) and squamous cell carcinoma of the skin (SCC), both of which both have increased markedly, probably because of altered habits of sun exposure. [2][3][4][5] Previous data on the role of ultraviolet radiation (UVR) causing OM have been contradictory, 6 but strong evidence was recently reported, particularly for the most common types of OM, chorioid and ciliary body melanoma.…”

Low penetrance breast cancer predisposition SNPs are site specific

“…Many of the common cancers are associated with a twofold increase in familial relative risk across the different cancer types [19]. This together with the finding of risk variants for breast, prostate, colon and ovarian cancer clustering at 8q24 suggests that there may be low penetrance susceptibility alleles elsewhere in the genome predisposing to all of these cancers.…”

Molecular pathology of uveal melanoma

“…Concerning predisposition to UM, rare reports of families with an excess of UM cases have been published. [1][2][3] Recent evidence suggests that patients with a cancer susceptibility may have higher frequencies of UM compared with the normal population. 4 Other risk factors are congenital ocular melanocytosis, melanocytoma, and neurofibromatosis.…”