Genetic relatedness of Mycobacterium avium-intracellulare complex isolates from patients with pulmonary MAC disease and their residential soils

Fujita, Kohei; Ito, Yutaka; Hirai, Toyohiro; Maekawa, Koichi; Imai, Seiichiro; Tatsumi, Shuji; Niimi, Akio; Iinuma, Yoshitsugu; Ichiyama, Satoshi; Mishima, Michiaki

doi:10.1111/j.1469-0691.2012.03929.x

Cited by 54 publications

(36 citation statements)

References 18 publications

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“…314 Another study isolated M. avium-intracellulare from 49% of residential soil samples in Japan and found 6 clinical and corresponding soil isolate pairs with identical genotypes from non-CF case patients with high soil exposure, defined as more than or equal to 2 hours/week, including digging or carrying soils, mowing grass, planting flowers, and exposure to soil dusts when farming or gardening. 315 Thus, although these studies were not conducted in people with CF, they do suggest that it may be prudent to limit exposure to soil.…”

Section: Iiid1 Nonhealthcare Sources: Soil Organic Matter and Watermentioning

confidence: 96%

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Saiman

Siegel

LiPuma

et al. 2014

Infect. Control Hosp. Epidemiol.

352

382

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The 2013 Infection Prevention and Control (IP&C) Guideline for Cystic Fibrosis (CF) was commissioned by the CF Foundation as an update of the 2003 Infection Control Guideline for CF. During the past decade, new knowledge and new challenges provided the following rationale to develop updated IP&C strategies for this unique population:1. The need to integrate relevant recommendations from evidence-based guidelines published since 2003 into IP&C practices for CF. These included guidelines from the Centers for Disease Control and Prevention (CDC)/Healthcare Infection Control Practices Advisory Committee (HICPAC), the World Health Organization (WHO), and key professional societies, including the Infectious Diseases Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA). During the past decade, new evidence has led to a renewed emphasis on source containment of potential pathogens and the role played by the contaminated healthcare environment in the transmission of infectious agents. Furthermore, an increased understanding of the importance of the application of implementation science, monitoring adherence, and feedback principles has been shown to increase the effectiveness of IP&C guideline recommendations.2. Experience with emerging pathogens in the non-CF population has expanded our understanding of droplet transmission of respiratory pathogens and can inform IP&C strategies for CF. These pathogens include severe acute respiratory syndrome coronavirus and the 2009 influenza A H1N1. Lessons learned about preventing transmission of methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant gram-negative pathogens in non-CF patient populations also can inform IP&C strategies for CF.

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Section: Iiid1 Nonhealthcare Sources: Soil Organic Matter and Watermentioning

confidence: 96%

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Saiman

Siegel

LiPuma

et al. 2014

Infect. Control Hosp. Epidemiol.

352

382

View full text Add to dashboard Cite

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“…In Japan, soil samples near the households of 100 patients with MAC pulmonary disease were also sampled. While 60% of all soil samples yielded MAC isolates, strains identical to the patients' clinical samples by 16-locus VNTR typing were identified for only 6 patients (5 M. avium strains and 1 M. intracellulare strain) (514).…”

Section: Molecular Typing Of Nontuberculous Mycobacteriamentioning

confidence: 99%

Methodological and Clinical Aspects of the Molecular Epidemiology of Mycobacterium tuberculosis and Other Mycobacteria

et al. 2016

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SUMMARYMolecular typing has revolutionized epidemiological studies of infectious diseases, including those of a mycobacterial etiology. With the advent of fingerprinting techniques, many traditional concepts regarding transmission, infectivity, or pathogenicity of mycobacterial bacilli have been revisited, and their conventional interpretations have been challenged. Since the mid-1990s, when the first typing methods were introduced, a plethora of other modalities have been proposed. So-called molecular epidemiology has become an essential subdiscipline of modern mycobacteriology. It serves as a resource for understanding the key issues in the epidemiology of tuberculosis and other mycobacterial diseases. Among these issues are disclosing sources of infection, quantifying recent transmission, identifying transmission links, discerning reinfection from relapse, tracking the geographic distribution and clonal expansion of specific strains, and exploring the genetic mechanisms underlying specific phenotypic traits, including virulence, organ tropism, transmissibility, or drug resistance. Since genotyping continues to unravel the biology of mycobacteria, it offers enormous promise in the fight against and prevention of the diseases caused by these pathogens. In this review, molecular typing methods forMycobacterium tuberculosisand nontuberculous mycobacteria elaborated over the last 2 decades are summarized. The relevance of these methods to the epidemiological investigation, diagnosis, evolution, and control of mycobacterial diseases is discussed.

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“…Several studies have used VNTR analysis to elucidate the sources and routes of MAC infection (Taga et al, 2012;Fujita et al, 2013). However, few studies have investigated the recurrence of pulmonary MAC disease.…”

Section: Discussionmentioning

confidence: 99%

Recurrence of pulmonary Mycobacterium avium complex disease due to endogenous reactivation

et al. 2014

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statement has shown that patients with pulmonary Mycobacterium avium complex (MAC) disease who complete 10-12 months of negative cultures on therapy but then have either single or multiple positive MAC cultures are more likely to have reinfection with a new MAC strain.Case presentation: A 63-year-old woman was diagnosed with pulmonary disease caused by clarithromycin (CAM)-susceptible MAC. Before initiating chemotherapy using a four-drug regimen containing CAM, an investigation of the patient's residential bathroom was conducted and one of the M. avium isolates recovered from the bathtub inlet was found to be genetically identical to sputum-derived isolates by variable number tandem repeats analysis using M. avium tandem repeat loci (MATR-VNTR). A second investigation of the bathroom during chemotherapy showed no M. avium isolates, and five consecutive sputum cultures were negative for 12 months until chemotherapy was discontinued. A recurrence occurred 3 months after the end of chemotherapy (at age 65 years). A third investigation of the bathroom was performed and MATR-VNTR analysis revealed that the VNTR profile of the M. avium isolates recovered from the sputum at recurrence was identical to that of the isolates recovered from the sputum at initial diagnosis and the bathroom at the first investigation. Conclusion:The recurrence occurred due to endogenous reactivation of the initial M. avium isolate despite drug treatment for 12 months after sputum culture conversion. Further genetic analyses of MAC isolates recovered from patients and environments should be encouraged.

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Genetic relatedness of Mycobacterium avium-intracellulare complex isolates from patients with pulmonary MAC disease and their residential soils

Cited by 54 publications

References 18 publications

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Methodological and Clinical Aspects of the Molecular Epidemiology of Mycobacterium tuberculosis and Other Mycobacteria

Recurrence of pulmonary Mycobacterium avium complex disease due to endogenous reactivation

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