Genetic relations between carcass fat and body weight in mice

Hull, P.

doi:10.1017/s0021859600023182

Cited by 28 publications

(16 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The differences in fatness between SF and CF at 91 days and probably therefore at maturity were very marked. This agrees with the majority of other studies, in which selection for postweaning growth rate or body weight has resulted in a correlated increase in fatness at a given age after weaning, (Hull, 1960;Biondini, Sutherland & Haverland, 1968;Timon, Eisen & Leatherwood, 1970;Hayes & McCarthy, 1976;McPhee & Neill, 1976). The C-strain studied by Fowler (1958), and the high line of Lang & Legates (1968) showed no such increase, although the practice of looking at body composition at only one age is dangerous (Hayes & McCarthy, 1976), and does not allow examination of developmental changes brought about by selection.…”

Section: Discussion (I) Comparison Of the Linessupporting

confidence: 91%

Growth, efficiency and body composition of mice selected for post-weaning weight gain onad libitumor restricted feeding

Hetzel

Nicholas

1986

Genet. Res.

View full text Add to dashboard Cite

After seven generations of selection, a line of mice selected for post-weaning (21-42 days) weight gain on full feeding (SF) showed significant increases of 49% in weight gain, 31% in efficiency and 14% in food intake, when compared with its control on full feeding between 21 and 42 days. After day 42, SF mice continued to eat more food and were 28% heavier than control mice at 91 days. Because SF mice were heavier than control mice at almost all ages, they were fatter on an age basis. There was, however, no change in the rate of deposition of fat, protein and ash relative to body weight. On restricted feeding between 21 and 42 days, SF mice showed a non-significant increase in weight gain, and hence in efficiency, of 12%. They deposited more fat than control mice during the feeding period but there was no significant difference when comparisons were made on a weight basis.A contemporary line of mice selected for post-weaning (21-42 days) weight gain on restricted feeding (SR) had significant increases of 12% in weight gain, 17% in efficiency but no significant change in food intake, when compared with its control on full feeding between 21 and 42 days. SR mice were the same weight as control mice at all ages except day 21, when they were significantly lighter due to direct genetic effects rather than maternal effects. SR mice had a lower (P<010) rate of fat deposition per unit body weight and became less fat relative to their control as body weight increased. The rate of deposition of other components was not altered by selection. On restricted feeding, SR had a significant increase in weight gain, and hence in efficiency, of 37%. Changes in body composition were similar to those on full feeding.It was concluded that the use of a restricted feeding regime had enabled the exploitation of heritable variation in the partitioning of energy for growth. This variation was independent of genetic variation for appetite and body weight.Overall performance at each level of feeding was best improved by selection on that feeding level. The realized genetic correlation between post-weaning weight gain on full and restricted feeding was estimated to be 0-28 + 008, indicating a very different genetic basis for the same character in the two feeding environments.

show abstract

Section: Discussion (I) Comparison Of the Linessupporting

confidence: 91%

Growth, efficiency and body composition of mice selected for post-weaning weight gain onad libitumor restricted feeding

Hetzel

Nicholas

1986

Genet. Res.

View full text Add to dashboard Cite

show abstract

“…These results agree with previous work [23] and are based on the strong positive correlation between isolated fat depots and predicted fat mass.…”

Section: Discussionsupporting

confidence: 93%

Evaluating invasive and non-invasive methods to determine fat content in the laboratory mouse

et al. 2015

View full text Add to dashboard Cite

In the midst of an obesity epidemic in humans, diet induced obesity studies in rodents are fundamental to unravel the complex mechanisms underlying this disease, ultimately resulting in the identification of new preventative and therapeutic strategies. The current study was designed to determine if high throughput multiobject CT scanning was capable of providing precise quantification of adipose tissue in C57BL/6 mice when benchmarked to the gold standard method for evaluating fat mass (freeze drying). We report a strong correlation between body weight alone and fat percentage in our mouse cohort (20 g-40 g, r = 0.95). The gonadal fat depot was identified as the most accurate single predictor of total fat mass (r = 0.931). Importantly, we observed a high positive correlation between both live tissue weight and dissected adipose tissue when correlated to CT predictions (r ≥ 0.862), suggesting CT can accurately be used to predict total fat mass/percentage and non-fat mass/percentage in our cohort. We conclude that the use of multi-object in vivo CT fat quantification is cost effective, accurate and minimally invasive technique in the genetic manipulation era to exploit lean/obese genes in the study of diet induced obesity, allowing longitudinal studies to be completed in a high throughput manner.

show abstract

“…The chemical components in adipose tissue were analyzed on the epididymal fat pad of these mice and the weight of the pad was also used as an index of the fatness of the animal. Hull [1960] has shown the weight of this fat body to be highly correlated with the total body fat.…”

Section: Analyses Of Mouse Adipose Tissuementioning

confidence: 99%

The Chemical Composition of Adipose Tissue of Man and Mice

Thomas

1962

Exp Physiol

168

View full text Add to dashboard Cite

The chemical composition of human and mouse adipose tissue taken from fat and thin individuals has been determined.The tissues were obtained from the epididymal fat pads of fat, lean and normal strains of mice and from sixty-one human subjects undergoing various abdominal operations. In both the mice and the humans, the adipose tissue from obese individuals contained slightly more fat and less protein and water than that from lean individuals. However, the differences were small and it is concluded that obese individuals containi, in their total adipose tissue, much more non-fatty cellular material than do the lean.

show abstract

Genetic relations between carcass fat and body weight in mice

Cited by 28 publications

References 4 publications

Growth, efficiency and body composition of mice selected for post-weaning weight gain onad libitumor restricted feeding

Growth, efficiency and body composition of mice selected for post-weaning weight gain onad libitumor restricted feeding

Evaluating invasive and non-invasive methods to determine fat content in the laboratory mouse

The Chemical Composition of Adipose Tissue of Man and Mice

Contact Info

Product

Resources

About