2020
DOI: 10.1007/s11605-020-04693-5
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Genetic Risk Factors for Diverticular Disease—Emerging Evidence

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Cited by 13 publications
(7 citation statements)
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References 37 publications
(30 reference statements)
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“…This phenomenon might be explained by the fact that some genes, such as LAMB4, TNFSF15, ARHGAP15, ANO1, ELN, and SPINT2, play known roles in processes logically related to diverticulitis, including inflammation, intestinal transport, intestinal motility, and extracellular matrix formation. 59,60 Our study failed to show the effect of other risk factors of colorectal lesions that need further investigation.…”
Section: Number Of Diverticulamentioning
confidence: 61%
“…This phenomenon might be explained by the fact that some genes, such as LAMB4, TNFSF15, ARHGAP15, ANO1, ELN, and SPINT2, play known roles in processes logically related to diverticulitis, including inflammation, intestinal transport, intestinal motility, and extracellular matrix formation. 59,60 Our study failed to show the effect of other risk factors of colorectal lesions that need further investigation.…”
Section: Number Of Diverticulamentioning
confidence: 61%
“…The mechanism of the difference is unknown. Given the complex relationship among genetic 12 , dietary habits ,gender, BMI and lifestyle 3,8,18,19 . In addition, colonoscopy is used worldwide to detective colonic diverticula, however, it can miss diverticula, especially the left-side ones 20 .…”
Section: Discussionmentioning
confidence: 99%
“…In addition to the studies included in this review, other studies have identified several risk factors with a positive association in the development of this inflammatory process, including medications, genetic factors, smoking, obesity, sedentary lifestyle, alteration of intestinal microflora, age, among other less significant conditions (4,13,(18)(19)(20)(21)(22)(23)(24) . Despite the increase in research on this disease, guiding new paths regarding its approach and treatment, the understanding of the pathogenesis of diverticulitis is still superficial.…”
Section: Discussionmentioning
confidence: 99%