Genetic risk score based on fat mass and obesity-associated, transmembrane protein 18 and fibronectin type III domain containing 5 polymorphisms is associated with anthropometric characteristics in South Brazilian children and adolescents

Todendi, Pâmela Ferreira; Klinger, Elisa Inês; Geraldo, Ana Caroline Regner; Brixner, Lucas; Reuter, Cézane Priscila; Lindenau, Juliana Dal-Ri; Valim, Andréia Rosane Moura; Fiegenbaum, Marilu

doi:10.1017/s0007114518002738

Cited by 15 publications

(9 citation statements)

References 38 publications

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“…Based on different genetic models, the results showed that TT genotype of FNDC5 (rs16835198) increased the risk of overweight or obesity in children and adolescents. Todendi et al 30 reported that TT genotype of FNDC 5 (rs16835198) increased risk of obesity in South Brazilian children and adolescents. The studies showed that the obese adults with TT genotype of FNDC 5 (rs16835198) had higher levels of total cholesterol (TC), triacylglycerol (TG) and low-density lipoprotein (LDL-C), lower levels of high-density lipoprotein (HDL-C).…”

Section: Discussionmentioning

confidence: 99%

An Association Between FNDC5, PGC-1α Genetic Variants and Obesity in Chinese Children: A Case-Control Study

Wang¹,

Zhang²,

Wu³

et al. 2023

DMSO

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Background Fibronectin type III domain containing protein 5 ( FNDC5 ) gene encodes irisin that regulates adipose tissue metabolism. Peroxide-proliferator-activated receptor γ coactivator 1α ( PGC-1α ) is a powerful promoter of mitochondrial biosynthesis and oxidative metabolism, which plays an important role in inducing heat production and energy consumption of brown fat. PGC1-α expression stimulated an increase in expression of FNDC5 . Purpose The aims of this study were to analyze the association between FNDC5, PGC-1α genetic variants and overweight or obesity in Chinese children and adolescents. Methods A total of 198 children and adolescents with overweight or obesity and 198 children and adolescents with normal weight were screened according to gender and age 1:1. The healthy eating behaviors, moderate-to-vigorous physical activity time were surveyed using food frequency questionnaire and CLASS questionnaire, respectively. Genotypes of FNDC5 and PGC-1α gene were detected using SNaPshot method. Results GT genotype of FNDC 5 (rs16835198) increased the risk of overweight or obesity in boys (OR (95% CI): 1.68 (1.00, 2.93)) based on overdominant model; GG genotype of FNDC 5 (rs16835198) decreased the risk of overweight or obesity in girls and boys (OR (95% CI): 0.45 (0.21,0.97), 0.45 (0.24, 0.83), respectively) based on dominant model; TT genotype of FNDC 5 (rs16835198) increased the risk of overweight or obesity in girls based on recessive model (OR (95% CI): 2.46 (1.19, 5.05)), and based on the additive model (OR (95% CI): 3.82 (1.49, 9.80)). There was significant interaction between FNDC 5 (rs16835198) and PGC -1α (rs3755863, rs8192678), healthy eating behaviors, moderate-to-vigorous physical activity time, interaction between PGC-1α (rs8192678) and moderate-to-vigorous physical activity time in the occurrence of overweight or obesity in Chinese children and adolescents. Conclusion FNDC5 (rs16835198) played an independent or interactive role with PGC -1α (rs3755863, rs8192678), healthy eating behaviors, moderate-to-vigorous physical activity time in the occurrence of overweight or obesity in Chinese children and adolescents.

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Section: Discussionmentioning

confidence: 99%

An Association Between FNDC5, PGC-1α Genetic Variants and Obesity in Chinese Children: A Case-Control Study

Wang¹,

Zhang²,

Wu³

et al. 2023

DMSO

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“…However, it must be considered that the prevention and treatment of childhood obesity is a complex task. Additionally, it is known that this disease is of polygenic origin, and other genes are also associated with it, including MCR4 , LEP , FTO, and TMEM18 [ 14 , 32 ]. Knowing that increasing levels of physical activity is an important part of the process, we should mention mechanisms for promoting a more active lifestyle.…”

Section: Discussionmentioning

confidence: 99%

“…This association suggests that FNDC5 is beneficial for the treatment of obesity, diabetes, and a variety of pathological conditions characterized by an imbalance in energy expenditure [ 13 ]. It is observed that the human locus FNDC5 rs16835198 contributed positively to anthropometric phenotypes in a previous Brazilian study [ 14 ]. However, the role of specific components of physical fitness in the relationship between FNDC5 polymorphism and adiposity is not known.…”

Section: Introductionmentioning

confidence: 99%

Cardiorespiratory Fitness and Muscular Strength Moderates the Relationship between FNDC5 Polymorphism and Adiposity in Children and Adolescents

Todendi

Brand

Silveira

et al. 2021

IJERPH

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The human locus FNDC5 rs16835198 contributes positively to anthropometric phenotypes in children and adolescents. However, the role of specific components of physical fitness in this relationship is not known. The present study aimed to verify the moderator role of cardiorespiratory fitness (CRF) and muscular strength in the relationship between rs16835198 polymorphism FNDC5 and adiposity in children and adolescents. This cross-sectional study was carried out by genotyping the rs16835198 FNDC5 polymorphism in 1701 children and adolescents (mean age 11.73 ± 2.75 years). Obesity was assessed using waist circumference and body mass index (BMI) z-scores. To evaluate CRF and muscular strength, the 6 min run/walk test and lower limb strength (LLS) were used. Linear regression models were applied, and all analyses were adjusted for age, sex, skin color, living area, and school type. A significant interaction term for CRF (p = 0.038) and LLS (p = 0.040) × rs16835198 FNDC5 with WC was identified. Regarding BMI, a significant interaction term for CRF (p = 0.007) and LLS (p = 0.044) × rs16835198 FNDC5 was observed. Moreover, medium and high CRF and LLS levels protected against higher WC and BMI. In conclusion, adiposity levels of children and adolescents with a genetic predisposition to obesity might be modified by improving CRF and muscular strength.

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“…TaqMan™ assays C__29311887_10 (rs6548238), C__30090620_10 (rs9939609) and C__34204885_10 (rs16835198) and Master Mix PCR Universal were purchased from Applied Biosystems. The genetic risk score (GRS) was based on previously associated obesity single‐nucleotide polymorphism (SNP) rs9939609 ( FTO ), rs6548238 ( TMEM18 ), and rs16835198 ( FNDC5 ) 23 . The unweighted GRS was constructed using a genotypic score based on the number of unfavorable alleles (those associated with higher levels of BMI Z‐score and waist circumference) that were carried by each subject for each of the three SNP 24 …”

Section: Methodsmentioning

confidence: 99%

Physical fitness attenuates the genetic predisposition to obesity in children and adolescents

Todendi

Brand

Silveira

et al. 2020

Scandinavian Med Sci Sports

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Obesity is an important risk factor associated with non‐communicable cardiometabolic diseases. Previous studies have indicated that children and adolescents with a predisposed genetic risk for obesity could benefit from an active lifestyle, but there are no studies investigating whether physical fitness moderates the association of genetics and obesity. The aim of this study was to verify the moderating role of physical fitness in the relationship between genetic risk score (GRS) and body mass index (BMI) in children and adolescents. This cross‐sectional study was carried out with 1471 children and adolescents, aged between 6 and 17 years from Santa Cruz do Sul, Brazil. Weight and height were assessed to determine BMI. Physical fitness components (cardiorespiratory fitness [CRF], lower limb strength [LLS], upper limb strength, and abdominal strength) were evaluated. The GRS was based on previously associated obesity single‐nucleotide polymorphism rs9939609 (FTO), rs6548238 (TMEM18), and rs16835198 (FNDC5). Moderation analyses were tested using linear regression models, and the interactions were represented by physical fitness components X GRS (categorical variable). All analyses were adjusted for skin color/ethnicity, sex, and sexual maturation. Significant interactions for CRF (P = 0.041), LLS (P = 0.041), and abdominal strength (P = 0.046) X 5 and 6 risk alleles with BMI were found only in adolescents. In addition, there was evidence that fitness components attenuated the high genetic predisposition to high BMI. Physical fitness components are moderators in the relationship between GRS and BMI in adolescents. These findings highlight the need for interventions targeting to improve this aspect, which is an important health indicator in all ages.

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Genetic risk score based on fat mass and obesity-associated, transmembrane protein 18 and fibronectin type III domain containing 5 polymorphisms is associated with anthropometric characteristics in South Brazilian children and adolescents

Cited by 15 publications

References 38 publications

An Association Between FNDC5, PGC-1α Genetic Variants and Obesity in Chinese Children: A Case-Control Study

An Association Between FNDC5, PGC-1α Genetic Variants and Obesity in Chinese Children: A Case-Control Study

Cardiorespiratory Fitness and Muscular Strength Moderates the Relationship between FNDC5 Polymorphism and Adiposity in Children and Adolescents

Physical fitness attenuates the genetic predisposition to obesity in children and adolescents

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