Genetic structure of milk protein polymorphisms and effects on milk production traits in a local dairy cattle

Caroli, Anna; Chessa, S.; Bolla, P.; Budelli, E.; Gandini, G.

doi:10.1111/j.1439-0388.2003.00443.x

Cited by 59 publications

(53 citation statements)

References 33 publications

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“…The most common alleles are A, B and E (Neubauerová, 2001). Allele A is associated with higher milk yield but lower protein content, while allele B is linked with higher protein content (Neubauerová, 2001) and higher milk quality (Strzalkowska et al, 2002) but lower milk yield (Boettcher et al, 2004;Caroli et al, 2004). The negative effect of allele E on milk protein quality was reported by Ikonen et al (1997).…”

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confidence: 83%

Joint effects of CSN3 and LGB genotypes and their relation to breeding values of milk production parameters in Czech Fleckvieh

Matéjicek¹,

Matějíčková²,

Němcová³

et al. 2007

CZECH J ANIM SCI

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ABSTRACT:The objective of this study was to estimate the joint effects of CSN3 and LGB genotypes on breeding values of milk production parameters. CSN3 (kappa-casein) and LGB (beta-lactoglobulin) genotypes of 120 Czech Fleckvieh sires were detected using the PCR-RFLP method. Breeding values of sires were obtained from the Official Database of Progeny Testing. Ten genotype combinations were detected. Genotypes ABAB (25.0%), ABAA (13.3%) and ABBB (13.3%) were the most frequent. Significant effects of genotype combinations on breeding values for fat and protein content were found. The highest breeding values for milk (+621 kg) and protein (+15.8 kg) yields were associated with genotype combination ABAA, while the highest breeding values for content parameters (+0.15% for protein content and +0.55% for fat content) were associated with genotype combination BBAB.

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confidence: 83%

Joint effects of CSN3 and LGB genotypes and their relation to breeding values of milk production parameters in Czech Fleckvieh

Matéjicek¹,

Matějíčková²,

Němcová³

et al. 2007

CZECH J ANIM SCI

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“…Os alelos A e B (κ-caseína) estão associados à maior produção de leite e proteína (Caroli et al, 2004;Dagnachew et al, 2011). Aleandri et al (1990) relataram efeito quantitativo de variantes genotípicas do gene para β-lactoglobulina sobre a composição do leite e as propriedades do queijo.…”

Section: Introductionunclassified

Associação de SNPs nos genes para κ-caseína e β-lactoglobulina com curvas de lactação em cabras leiteiras

Cardona

Álvarez

Sarmento

et al. 2015

Pesq. agropec. bras.

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Resumo -O objetivo deste trabalho foi identificar o modelo com melhor ajuste aos dados de produção de leite, gordura, proteína e sólidos totais para cabras leiteiras, bem como associar polimorfismos de nucleotídeo único (SNPs) nos genes para κ-caseína (κ-CSN3) e β-lactoglobulina (β-LG) aos parâmetros das curvas de produção e qualidade do leite. Foram avaliados 4.160 registros de produção de leite, gordura, proteína e sólidos totais de cabras das raças Alpina, Saanen e mestiça, no Estado de Antioquia, na Colômbia. Os modelos não lineares com melhor ajuste à estrutura dos dados foram os de Nelder, para produção de leite, e de Cappio-Borlino, para qualidade do leite. As análises de associação mostraram efeito significativo do SNP κ-CSN3 sobre o pico de produção, a produção inicial e a persistência das características qualitativas do leite. Já o SNP β-LG apresentou efeito significativo sobre os picos de produção de leite e gordura, e sobre o tempo necessário para atingir o pico de produção de proteína. A identificação e a estimação da influência dos marcadores SNP avaliados sobre as curvas de lactação e a qualidade do leite podem contribuir para a seleção de caprinos leiteiros.Termos para indexação: Capra hircus, controle leiteiro, modelos não lineares, polimorfismo de nucleotídeo único, qualidade do leite, seleção assistida por marcadores. Association of SNPs in the genes for κ-casein and β-lactoglobulin with lactation curves in dairy goatsAbstract -The objective of this work was to identify the model that best fits production data of milk, fat, protein, and total solids for dairy goats, as well as to associate single-nucleotide polymorphisms (SNPs) in the genes for κ-casein (κ-CSN3) and β-lactoglobulin (β-LG) with parameters from lactation and milk-quality curves. A total of 4,160 production records of milk, fat, protein, and total solids from goats of the Alpine, Saanen, and crossbred breeds, in the state of Antioquia, Colombia, were evaluated. The nonlinear models with the best fit to data structure were Nelder's, for milk yield, and Cappio-Borlino's, for milk quality. Association analyzes showed significant effect of the SNP κ-CSN3 on production peak, initial production, and persistence of milk-quality traits. The SNP β-LG had significant effect on the peaks of milk and fat yield, and on the time required to reach the peak of protein yield. The identification and estimation of the influence of the evaluated SNP markers on lactation and milk-quality curves can contribute for dairy goat selection.

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“…This was first suggested in cattle by Grosclaude et al (1978) and was further developed in the same species (Aleandri et al, 1990;Ikonen et al, 2001;Boettcher et al, 2004;Caroli et al, 2004). The effect of an allele at a given locus could be confounded with the effect of linked alleles at another locus.…”

Section: Introductionmentioning

confidence: 99%

Casein Haplotype Structure in Five Italian Goat Breeds

Sacchi¹,

Chessa

Budelli

et al. 2005

Journal of Dairy Science

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The aim of this work was to investigate the genetic structure of the casein gene cluster in 5 Italian goat breeds and to evaluate the haplotype variability within and among populations. A total of 430 goats from Vallesana, Roccaverano, Jonica, Garganica, and Maltese breeds were genotyped at α s1 -casein (CSN1S1), α s2 -casein, (CSN1S2), β-casein (CSN2), and κ-casein (CSN3) loci using several genomic techniques and milk protein analysis. Casein haplotype frequencies were estimated for each breed. Principal component analysis was carried out to highlight the relationship among breeds. Allele and haplotype distributions indicated considerable differences among breeds. The haplotype CSN1S1*F-CSN1S2*F-CSN3*D occurred in all breeds with frequencies >0.100 and was the most common haplotype in the Southern breeds. A high frequency of CSN1S1*0-CSN1S2*C-CSN3*A haplotype was found in Vallesana population (0.162). Principal component analysis clearly separated the Northern and Southern breeds by the first component. The variability of the caprine casein loci and variety of resulting haplotypes should be exploited in the future using specific breeding programs aiming to preserve biodiversity and to select goat genetic lines for specific protein production. (Key words: goat, casein, polymorphism, haplotype) Abbreviation key: AS-PCR = allele specific-PCR, CSN1S1 = α s1 -casein locus, CSN1S2 = α s2 -casein locus, CSN3 = κ-casein locus, CSN2 = β-casein locus, IEF = isoelectrofocusing, PCR-SSCP = PCR-single strand conformational polymorphism.

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Genetic structure of milk protein polymorphisms and effects on milk production traits in a local dairy cattle

Cited by 59 publications

References 33 publications

Joint effects of CSN3 and LGB genotypes and their relation to breeding values of milk production parameters in Czech Fleckvieh

Joint effects of CSN3 and LGB genotypes and their relation to breeding values of milk production parameters in Czech Fleckvieh

Associação de SNPs nos genes para κ-caseína e β-lactoglobulina com curvas de lactação em cabras leiteiras

Casein Haplotype Structure in Five Italian Goat Breeds

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