Genetic Studies on Polycystic Ovary Syndrome

Zhao, Han; Lv, Yue; Li, Lei; Chen, Zi‐Jiang

doi:10.1016/j.bpobgyn.2016.04.002

Cited by 53 publications

(40 citation statements)

References 92 publications

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“…It is complex and a diverse female endocrine and metabolic disorder that affect women throughout their lifetime, leading to several health complications including menstrual irregularity/disorder, infertility, hirsutism, acne, obesity, and metabolic syndrome. [33] The adverse impact of this heterogeneous condition on psychological features (worsen QOL, depression, and anxiety) has become an important indicator of research in the recent last decade. [34] However, data on women's experience of common PCOS problems and their impact on QOL in Beni-Suef is scanty, therefore, the aim of the study was to determine the impact of PCOS on QOL among the studied women.…”

Section: Discussionmentioning

confidence: 99%

The impact of polycystic ovary syndrome on women’s quality of life: Nursing guidelines for its

Hassan

Farg

2019

CNS

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Background: Polycystic ovary syndrome (PCOS) is an uncertain-etiology heterogeneous disorder, which affects 6.0% to 10.0% of women in their reproductive age. Aim: assess phenotypic characteristics of women with PCOS, discovery the association between women's quality-of-life (QOL) and its occurrence and improve women's knowledge & increase awareness regarding PCOS. Methods: A descriptive cross-sectional design had been utilized on a purposive sample of 300 women in reproductive age with PCOS in the gynecological outpatient clinic at Beni-Suef General Hospital, Egypt. A structured interviewing schedule, patient's assessment record, visual-analogue-scale, Ferriman-Gallwey-Evaluation-of-Hirsutism, QOL Questionnaire, Short-Form-Health-Survey (SF-36), and designed intervention nursing-guideline had been used for data collection. Results: A high percentage (56.7%) of women had a complete phenotype characteristics of PCOS. The most prevalent phenotypic characteristics were alopecia (65.0%), irregular menses (58.7%), and obesity/overweight (48.1%). Statistically significant was found between women's general characteristic of PCOS and their age, body-mass-index, hirsutism, and average cycle length, p < .05. Women's QOL had affected negatively by PCO Syndrome, p < .05. Conclusions: PCOS is a common risk factor for acne, alopecia, hirsutism. Many factors to be associated with its phenotype as: body-mass-index, hirsutism, and average cycles length. It has a negative impact on phenotype characteristic, psychological/social domain and total QOL scale. The nursing guideline had a crucial role in the improvement of women's knowledge in allover items of women's knowledge. Recommendation: Upgrading women's knowledge concerning PCOS with a periodic screening of women for early detection and management. Health-Promotion-Programs through different media to improve QOL for women with PCOS.

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Section: Discussionmentioning

confidence: 99%

The impact of polycystic ovary syndrome on women’s quality of life: Nursing guidelines for its

Hassan

Farg

2019

CNS

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“…Finally, as these changes in the oocyte mitochondria are transferred to the offspring, this may explain the inheritance pattern seen in the offspring of PCOS patients (53). PCOS is well known to be hereditary, though numerous studies investigating the genetic contributions to the disease have been unable to identify strong gene candidates to explain this pattern (54,55,56). Other alternative explanations may include alterations in mitochondrial DNA, increased cellular stress resulting in apoptosis or perhaps via direct effects to the mitochondria itself (26,29,42).…”

Section: Figurementioning

confidence: 99%

Prenatal androgen induced lean PCOS impairs mitochondria and mRNA profiles in oocytes

Chappell

Zhou

Schutt

et al. 2020

Endocrine Connections

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Polycystic ovary syndrome (PCOS) is the most common ovulatory defect in women. Although most PCOS patients are obese, a subset of PCOS women are lean but show similar risks for adverse fertility outcomes. A lean PCOS mouse model was created using prenatal androgen administration. This developmentally programmed mouse model was used for this study. Our objective was to investigate if mitochondrial structure and functions were compromised in oocytes obtained from lean PCOS mouse. The lean PCOS mouse model was validated by performing glucose tolerance test, HbA1c levels, body weight and estrous cycle analyses. Oocytes were isolated and were used to investigate inner mitochondrial membrane potential, oxidative stress, lipid peroxidation, ATP production, mtDNA copy number, transcript abundance and electron microscopy. Our results demonstrate that lean PCOS mice have similar weight to that of the controls but exhibit glucose intolerance and hyperinsulinemia along with dysregulated estrus cycle. Analysis of their oocytes show impaired inner mitochondrial membrane function, elevated reactive oxygen species (ROS) and increased RNA transcript abundance. Electron microscopy of the oocytes showed impaired mitochondrial ultrastructure. In conclusion, the lean PCOS mouse model shows a decreased oocyte quality related to impaired mitochondrial ultrastructure and function.

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“…In addition, first-degree relatives of both genders of women with PCOS are also at increased risk of presenting the metabolic disorders associated with this syndrome (Norman et al 2007). More than 100 candidate genes have been evaluated in previous studies, most of which are related to reproductive hormones, cellular metabolism, chronic inflammation, cell proliferation, and hemostasis (Jia et al 2012;Ruan et al 2012;Sales et al 2013;Zhao et al 2016;Hosseini et al 2017;Reddy et al 2018). More recently, Genome Patients have a dysfunction in the hypothalamic-pituitary-gonadal axis, which influences steroidogenesis.…”

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confidence: 99%

Polycystic Ovary Syndrome as a systemic disease with multiple molecular pathways: a narrative review

Carvalho

Reis

Cândido

et al. 2018

Endocrine Regulations

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Polycystic Ovary Syndrome (PCOS) is characterized by hyperandrogenism, amenorrhea, and polycystic ovaries. This endocrinopathy is associated with many metabolic disorders such as dyslipidemia and insulin resistance, with increased risk of type 2 diabetes mellitus, metabolic syndrome, and cardiovascular complications. Inflammation is likely to play an important role in the promoting these metabolic imbalances, while prothrombotic and pro-oxidative mechanisms further contribute to the cardiovascular risk of these patients. The etiology of PCOS is still not fully understood, but there is evidence of genetic and environmental components. This review aims to discuss some molecular pathways associated with PCOS that could contribute to the better understanding about this syndrome. Recent evidence suggests that intrauterine exposure of female mice to an excess of anti-Müllerian hormone may induce PCOS features in their post-natal life. High cytokine levels and cytokine gene polymorphisms also appear to be associated with the pathophysiology of PCOS. Furthermore, high levels of microparticles may contribute to the altered hemostasis and enhanced inflammation in PCOS. All these mechanisms may be relevant to clarify some aspects of PCOS pathogenesis and inspire new strategies to prevent the syndrome as well as treat its symptoms and mitigate the risk of long-term complications.

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Genetic Studies on Polycystic Ovary Syndrome

Cited by 53 publications

References 92 publications

The impact of polycystic ovary syndrome on women’s quality of life: Nursing guidelines for its

The impact of polycystic ovary syndrome on women’s quality of life: Nursing guidelines for its

Prenatal androgen induced lean PCOS impairs mitochondria and mRNA profiles in oocytes

Polycystic Ovary Syndrome as a systemic disease with multiple molecular pathways: a narrative review

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