Genetic Susceptibility to Periapical Disease: Conditional Contribution of MMP2 and MMP3 Genes to the Development of Periapical Lesions and Healing Response

Menezes-Silva, Renato; Khaliq, Shahryar; Deeley, Kathleen; Letra, Ariadne; Vieira, Alexandre R.

doi:10.1016/j.joen.2012.02.009

Cited by 86 publications

(96 citation statements)

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“…The hypothesis that individual genetic susceptibility through gene polymorphisms can contribute to periapical disease risk has been explored recently in the literature (10)(11)(12)(13)(14). However, gene polymorphisms may explain only a fraction of the associated risk because other genetic or ''epigenetic'' events may confer additional susceptibility to disease.…”

Section: Discussionmentioning

confidence: 99%

“…Recent evidence suggests that genetic predisposition of the host can contribute to an individual's susceptibility to persistent apical periodontitis (10)(11)(12)(13)(14). Polymorphisms in disease-relevant genes, such as cytokines and matrix metalloproteinases, have been shown to be associated with pulpal and periapical pathologies (10)(11)(12). Moreover, there has been some evidence pointing to the hypothesis that epigenetic factors may also play an important role in pulpal and periapical disease (15,16).…”

mentioning

confidence: 99%

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FOXP3 DNA Methylation Levels as a Potential Biomarker in the Development of Periapical Lesions

Campos

Franscisconi

Okehie

et al. 2015

Journal of Endodontics

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

FOXP3 DNA Methylation Levels as a Potential Biomarker in the Development of Periapical Lesions

Campos

Franscisconi

Okehie

et al. 2015

Journal of Endodontics

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“…MMP2 expression is higher in dentin affected by caries [Toledano et al, 2010]. When the presence of periapical lesions associated with deep carious lesions in dentin was used as a phenotype (in comparison to absence of periapical lesions despite the presence of deep carious lesions in dentin), associations were found with MMP2 and MMP3 [Menezes-Silva et al, 2012], demonstrating the promise of exploring phenotypes related to the severity of the carious lesions.…”

Section: Candidate Gene Studiesmentioning

confidence: 99%

Caries: Review of Human Genetics Research

Vieira¹,

Modesto²,

2014

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The NIH Consensus Development Program released a statement in 2001 (http://consensus.nih.gov/2001/2001DentalCaries115html.htm) and listed six major clinical caries research directions. One of these directions was the need for genetic studies to identify genes and genetic markers of diagnostic, prognostic and therapeutic value. This last decade has seen a steep increase in studies investigating the presence of genetic factors influencing individual susceptibility to caries. This review revisits recent caries human genetic studies and provides a perspective for future studies in order to fulfil their promise of revolutionizing our understanding of and the standard of care for the most prevalent bacteria-mediated non-contagious disease in the world.

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“…Due to their various roles in bone remodeling, immune responses, caries, and dental development, it is hypothesize that variation in MMPs and TIMP genes may alter the level of bone destruction and remodeling and contribute to the formation of more extensive periapical lesions in teeth affected by deep carious lesions [19,20].…”

Section: Discussionmentioning

confidence: 99%