Genetic toxicology of 1,2-dibromo-3-chloropropane (DBCP)

Teramoto, Shoji; Shirasu, Yasuhiko

doi:10.1016/0165-1110(89)90042-0

Cited by 13 publications

(2 citation statements)

References 43 publications

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“…This will cause a smear in the gel resembling a ''comet tail,'' the size of which correlates with the extent of DNA damage that has occurred in the cells. Several reprotoxins and genotoxins have been tested with this assay including dibromochloropropane [Teramoto and Shirasu, 1989;Ulbrich and Palmer, 1995] and ethylene glycol monomethyl ether [McGregor et al, 1983]. This assay may be useful for testing substances that are suspected of being possible mutagens and may have a particular affinity for germ cells; otherwise, its use for screening or identifying reproductive toxins may be limited.…”

Section: Research Needsmentioning

confidence: 99%

Assessment of the U.S. Environmental Protection Agency methods for identification of hazards to developing organisms, Part I: The reproduction and fertility testing guidelines

1999

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Background Successful reproduction depends on the coordination of many processes, particularly the normal development and subsequent maturation of the sexual organs. The Food Quality Protection Act of 1996 mandates that the U.S. Environmental Protection Agency must protect infants and children from the effects of toxins, including those that affect the reproductive system. Therefore, the Agency finds itself at a critical juncture to make sure that the methods it requires for toxicity testing, the Health Effects Test Guidelines or Series 870 Guidelines, are adequate to determine possible toxicity to children. Methods and Results We found that two testing protocols included in the core guidelines assess toxicological effects on developing animals. This article aims to provide a detailed analysis of the protocols included in the Reproduction and Fertility Effects Test Guideline. An accompanying article assesses the Developmental Toxicity Testing Guideline. We conducted this analysis on the basis of whether the test would yield the information needed to adequately determine risk to infants and children. Conclusions Our analysis concludes that given the limitations inherent in testing for reproduction and fertility effects during development, it is necessary to include a safety factor during risk assessment of chemicals. This action will fulfill the mandate expressed in the FQPA to protect infants and children from environmental hazards. Am. J. Ind. Med. 35:543–553, 1999. © 1999 Wiley‐Liss, Inc.

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Section: Research Needsmentioning

confidence: 99%

Assessment of the U.S. Environmental Protection Agency methods for identification of hazards to developing organisms, Part I: The reproduction and fertility testing guidelines

1999

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“…Dibromochloropropane is a known reprotoxin to man [14,15] and a genotoxin [16] and ethylene glycol monomethyl ether has been shown to affect germ cell parameters [17,18] and has been reported to be mutagenic in mammalian cells [19,20]. Reproductive effects of lead compounds have been recognized for 2 decades and lead intoxication has been associated with sterility, abortion, stillbirths, neonatal morbidity, and mortality from exposure to lead in vitro [21].…”

Section: Introductionmentioning

confidence: 99%