Genetic variability at promoters of IL-18 (pro-) and IL-10 (anti-) inflammatory gene affects susceptibility and their circulating serum levels: An explorative study of prostate cancer patients in North Indian populations

Associations of IL-10 genetic polymorphisms with the risk of urologic cancer: a meta-analysis based on 18,415 subjects

“…On the other hand, the anti-angiogenic property of IL-10 may inhibit microvasculature formation and tumor growth. Previous studies have found that serum level of IL-10 was significantly elevated in urologic cancer, and it was closely correlated with tumor progression and metastasis (Stearns et al 1999; Uwatoko et al 2002; Dwivedi et al 2015a, b), which suggested that IL-10 may play a vital role in the development of urologic cancer.…”

“…For IL - 10 −592C>A polymorphism, a total of 14 studies including 5899 urologic cancer patients and 6181 control subjects were investigated (Dluzniewski et al 2012; Dwivedi et al 2015a, b; Eder et al 2007; Faupel-Badger et al 2008; Liu et al 2010; VanCleave et al 2010; Wang et al 2009; Winchester et al 2015; Xu et al 2005; Zabaleta et al 2008; Basturk et al 2005; Cozar et al 2007; Chang et al 2016; Chen et al 2013). HWE test for the control group of each included studies demonstrated that only 1 study deviated from HWE (see Table 1).…”

“…A total of 13 studies with 4655 cancer cases and 6344 healthy controls were enrolled to evaluate the association between IL - 10 −819C>T polymorphism and urologic cancer risk (Dwivedi et al 2015a, b; Faupel-Badger et al 2008; Liu et al 2010; VanCleave et al 2010; Winchester et al 2015; Zabaleta et al 2008; Basturk et al 2005; Cozar et al 2007; Chang et al 2016; Chen et al 2013; Kesarwani et al 2009; Michaud et al 2006; Ahirwar et al 2009). HWE test for the control group of eligible studies revealed that 4 studies violated HWE (see Table 2).…”

Prospects of Molecular Biotechnology in Diagnostics: Step Towards Precision Medicine

“…The AP-1 transcription factor is a regulator of processes essential for normal growth and development as well as carcinogenesis. Similarly, pro-inflammatory and anti-inflammatory interleukin's genotypes and gene expression have established their role in survival of prostate cancer patients [3][4][5]. Thus molecular diagnostics is going to swing the whole paradigm of screening and treatment.…”

Association analysis of interleukin‐18 gene promoter region polymorphisms and susceptibility to sporadic breast cancer in Chinese Han women

“…Research showed that IL‐18 can suppress antitumor immunity in a programmed death‐1 (PD‐1)‐dependent manner, PD‐1 is a co‐inhibitory receptor and one of the major checkpoints . Furthermore, the association was verified between the 2 SNPs and the susceptibility to many cancers . However, studies focus on the role of IL‐18 polymorphisms on the risk of breast cancer remain controversial.…”