Genetic variability at the D1S80 minisatellite: predominance of allele 18 among some Indian populations

Abstract

This study at the D1S80 minisatellite on seven ethnic groups will provide useful information for the Indian population genetic database. However, the most important observation was the predominance of allele 18 among the majority of Indian ethnic groups. The reason is not clear yet and thus further studies on Indian ethnic groups from different regions are necessary to find out the importance of allele 18 as the predominant allele in Indian population.

Genetic polymorphism study at D1S80 VNTR in four major tribal populations (Garo, Santal, Khasia and Monipuri) of Bangladesh

“…Chi-square test showed significant deviation (*** P<0.001) in D1S80 allelic frequencies from the Hardy-Weinberg Equilibrium (HWE) in all four populations. Similar observations at D1S80 locus were reported earlier (Das and Seshadri, 2004;Trivedi et al, 2002;Vallinoto et al, 2003;Walsh and Eckhoff, 2007). This deviation might root from the more frequent presence of certain D1S80 alleles in populations as well as low representation of alleles at the bond ends of D1S80 allelic spectrum (Hutz et al, 1997;Trivedi et al, 2002).…”

“…D1S80 allele frequencies showed multi-modal distribution in all four populations. Multimodal distribution is a distinctive feature of the spectrum of D1S80 allele frequencies (Das and Seshadri, 2004;Limborska et al, 2011;Mastana and Papiha, 2001). Allele with 18 repeats was the most frequent in three populations (Garo, Khasia and Monipuri), while in Santals allele with 19 repeat was the most common.…”

“…Allele with 24 repeats is relatively more common in the African and the Caucasian populations (Bernal et al, 2000;Herrera et al, 2004;Koseler et al, 2012;Limborska et al, 2011;Soares-Vieira et al, 2000;Verbenko et al, 2006). In the majority of Indian sub-populations allele with 18 repeats was found to be the most prevalent one (Das et al, 2002;Das and Seshadri, 2004;Trivedi et al, 2002). Some mixed European populations also had higher frequencies of allele with 18 repeats (Verbenko et al, 2003).…”

“…D1S80 allele frequencies were studied in a large number of populations worldwide. In this study, 76 different population data (including the data presented in this study) (Al-Nassar et al, 1996;Alkhayat et al, 1996;Balamurugan et al, 2001;Bernal et al, 2000;Cabrero et al, 1995;Çakir et al, 2001;Cerda-Flores et al, 2002;Ciesielka et al, 1996;Das and Seshadri, 2004;Gutowski et al, 1995;Halos et al, 1999;Herrera et al, 2004;Keys et al, 1996;Lorentea et al, 1997;Mastana, 1999;Matamoros et al, 2004;Morales et al, 2001;Ruangjirachuporn et al, 2006;Sachdeva et al, 2004;Sajib et al, 2016;Soares-Vieira et al, 2000;Tenaglia et al, 2004;Trivedi et al, 2002;Vallinoto et al, 2003;Verbenko et al, 2006;Yunis et al, 2001) were fed into POPTREE2 and a phylogenetic tree was constructed following neighbor-joining (NJ) method (Figure 1). Phylogenetic analysis based on the D1S80 alleleic profiles placed the four indigenous populations along with the mainstream Bangladeshis, the north Indian Tamils and the mixed Panjabi Indians in a clade separated from the rest.…”

Genetic Variation and its Role in Malignancy

“…Tandemly repeated DNA can be divided into satellite DNA (highly repetitive DNA with repeat lengths of one thousand to several thousand base pairs (bp)), minisatellite DNA (moderately repetitive, 9-100 bp) and microsatellites (di-, tri-and tetra nucleotide repeats). Minisatellites are extremely polymorphic, which have made them excellent markers for DNA finger printing and linkage analysis (14)(15)(16). Microsatellites are very useful genetic markers (linkage analysis) as they are highly polymorphic, co-dominant and are spread approximately every 50 kb across the entire human genome (17,18).…”