Genetic variability of the glycoprotein genes of current wild-type measles isolates

Rota, Jennifer S.; Hummel, Kimberly B.; Rota, Paul A.; Bellini, William J.

doi:10.1016/0042-6822(92)90742-8

Cited by 164 publications

(97 citation statements)

References 26 publications

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“…Measles virus has traditionally been thought to be a relatively conserved RNA virus, since it confers life-long immunity on its hosts and those in the vaccinated class (Panum 1939) and because some earlier studies revealed low levels of both antigenic and genetic variation (Rota et al 1992). These observations led to suggestions that measles-and its relatives within in the Paramyxoviridae-evolve anomalously slowly.…”

Section: Discussionmentioning

confidence: 99%

The Evolutionary and Epidemiological Dynamics of the Paramyxoviridae

2008

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Paramyxoviruses are responsible for considerable disease burden in human and wildlife populations: measles and mumps continue to affect the health of children worldwide, while canine distemper virus causes serious morbidity and mortality in a wide range of mammalian species. Although these viruses have been studied extensively at both the epidemiological and the phylogenetic scales, little has been done to integrate these two types of data. Using a Bayesian coalescent approach, we infer the evolutionary and epidemiological dynamics of measles, mumps and canine distemper viruses. Our analysis yielded data on viral substitution rates, the time to common ancestry, and elements of their demographic history. Estimates of rates of evolutionary change were similar to those observed in other RNA viruses, ranging from 6.585 to 11.350 × 10 −4 nucleotide substitutions per site, per year. Strikingly, the mean Time to the Most Recent Common Ancestor (TMRCA) was both similar and very recent among the viruses studied, ranging from only 58 to 91 years (1908 to 1943). Worldwide, the paramyxoviruses studied here have maintained a relatively constant level of genetic diversity. However, detailed heterchronous samples illustrate more complex dynamics in some epidemic populations, and the relatively low levels of genetic diversity (population size) in all three viruses is likely to reflect the population bottlenecks that follow recurrent outbreaks.

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Section: Discussionmentioning

confidence: 99%

The Evolutionary and Epidemiological Dynamics of the Paramyxoviridae

2008

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“…The virus is monotypic, existing as a single serotype, and infection with one strain appears to provide life-long protection from the disease. With the development of RT/PCR and DNA sequencing techniques, it has become clear that virus isolates vary in their nucleotide sequences, especially in those encoding the last 150 amino acids of the N protein and the entire H protein [29][30][31][32]. At least 22 genotypes exist and these have been grouped into eight clades.…”

Section: Molecular Biology Of the Virusmentioning

confidence: 99%

Morbilliviruses and human disease

Rima

Duprex

2005

The Journal of Pathology

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Morbilliviruses are a group of viruses that belong to the family Paramyxoviridae. The most instantly recognizable member is measles virus (MV) and individuals acutely infected with the virus exhibit a wide range of clinical symptoms ranging from a characteristic mild selflimiting infection to death. Canine distemper virus (CDV) and rinderpest virus (RPV) cause a similar but distinctive pathology in dogs and cattle, respectively, and these, alongside experimental MV infection of primates, have been useful models for MV pathogenesis. Traditionally, viruses were identified because a distinctive disease was observed in man or animals; an infectious agent was subsequently isolated, cultured, and this could be used to recapitulate the disease in an experimentally infected host. Thus, satisfying Koch's postulates has been the norm. More recently, particularly due to the advent of exceedingly sensitive molecular biological assays, many researchers have looked for infectious agents in disease conditions for which a viral aetiology has not been previously established. For these cases, the modified Koch's postulates of Bradford Hill have been developed as criteria to link a virus to a specific disease. Only in a few cases have these conditions been fulfilled. Therefore, many viruses have over the years been definitely and tentatively linked to human diseases and in this respect the morbilliviruses are no different. In this review, human diseases associated with morbillivirus infection have been grouped into three broad categories: (1) those which are definitely caused by the infection; (2) those which may be exacerbated or facilitated by an infection; and (3) those which currently have limited, weak, unsubstantiated or no credible scientific evidence to support any link to a morbillivirus. Thus, an attempt has been made to clarify the published data and separate human diseases actually linked to morbilliviruses from those that are merely anecdotally associated.

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“…It should be noted that approximately half of the plaques on N 13Ve-20-infected monolayers was the latter type, which, nevertheless, exhibited marked haemadsorption (data not shown). When compared with other MV isolates, residues at positions 174, 252, 284, 296, 302 and 416 were shown to be conserved in more recent isolates (after 1983), and those at positions 243 and 276 were conserved in earlier ones (before 1968) including the Edmonston strain (see Rota et al, 1992Rota et al, , 1994.…”

Section: Deduced Amino Acid Sequence Analysis Of the H Protein Of MVmentioning

confidence: 99%

“…Shown are only the positions where sequence divergence between the above isolates and the Edmonston strain is observed. Symbols * and t indicate positions where residues are conserved in more recent isolates (after 1983), and in more previous ones (before 1968), respectively (see Rota et al, 1992Rota et al, , 1994. Hyphens indicate residues identical to those of the Edmonston strain.…”

Section: Deduced Amino Acid Sequence Analysis Of the H Protein Of MVmentioning

confidence: 99%

Increased binding activity of measles virus to monkey red blood cells after long-term passage in Vero cell cultures

Shibahara

Hotta

Katayama

et al. 1994

Journal of General Virology

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Recent field isolates of measles virus (MV) obtained by using B95-8 cells have been reported not to agglutinate African green monkey red blood cells (AGM-RBC). Vero cell-adapted, plaque-forming strains derived from three field isolates at the third passage in Vero cell cultures (T8Ve-3, T11Ve-3 and N13Ve-3) also exhibited markedly decreased binding activity, as determined by infectivity-absorption and haemadsorption tests. On the other hand, binding activity of the respective strains at the twentieth passage

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Genetic variability of the glycoprotein genes of current wild-type measles isolates

Cited by 164 publications

References 26 publications

The Evolutionary and Epidemiological Dynamics of the Paramyxoviridae

The Evolutionary and Epidemiological Dynamics of the Paramyxoviridae

Morbilliviruses and human disease

Increased binding activity of measles virus to monkey red blood cells after long-term passage in Vero cell cultures

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