Genetic variants associated with low-density lipoprotein cholesterol and systolic blood pressure and the risk of recurrent cardiovascular disease in patients with established vascular disease

Possible clinical usefulness of polygenic risk scores among patients with established atherosclerotic cardiovascular disease

“…The authors showed that the allele frequencies of the selected SNPs in the current study population were not different compared to the allele frequencies found in the general population from Europe [16]. With other additional analysis, although the authors replicated the known association of PRSs for LDL-C and SBP with these risk factors in patients with established cardiovascular disease, the authors concluded that there was no statistically significant association between an LDL-C PRS and an SBP PRS, nor in combination, and recurrent cardiovascular events [16].…”

“…However, the authors found no statistically significant association between an LDL-C PRS and an SBP PRS, nor in combination, and recurrent cardiovascular events [16]. Then, it would be important to examine possible contributing factors of these recurrent cardiovascular events in the study population: were there any differences in achieved levels of LDL-C and/or SBP during the cohort period of the study between patients with recurrent cardiovascular events and those without these events?…”

“…In the study by Groenland et al, the authors replicated the 275 association of a PRS for LDL-C and a PRS for SBP with these risk factors, constructed by 276 SNPs identified through the on-going, single-center, prospective cohort study in the Netherlands [16]. Groenland et al used data from patients enrolled in the Utrecht Cardiovascular Cohort-Second Manifestations of Arterial Disease (UCC-SMART) study [16,17]. The UCC-SMART study is an ongoing, single-center, prospective cohort at the tertiary referral center University Medical Center Utrecht (UMCU) in the Netherlands [17].…”

“…However, whether adding PRS to current clinical risk prediction algorithms is worthwhile is still under discussion [14,15]. Furthermore, the association between such PRS and recurrent cardiovascular events is uncertain, and this is examined in the paper published by Groenland et al in this issue of Atherosclerosis [16]. In the study by Groenland et al, the authors replicated the 275 association of a PRS for LDL-C and a PRS for SBP with these risk factors, constructed by 276 SNPs identified through the on-going, single-center, prospective cohort study in the Netherlands [16].…”

“…Furthermore, the association between such PRS and recurrent cardiovascular events is uncertain, and this is examined in the paper published by Groenland et al in this issue of Atherosclerosis [16]. In the study by Groenland et al, the authors replicated the 275 association of a PRS for LDL-C and a PRS for SBP with these risk factors, constructed by 276 SNPs identified through the on-going, single-center, prospective cohort study in the Netherlands [16]. Groenland et al used data from patients enrolled in the Utrecht Cardiovascular Cohort-Second Manifestations of Arterial Disease (UCC-SMART) study [16,17].…”