Genetic variants in the <i>ZNF208</i> gene are associated with esophageal cancer in a Chinese Han population

Wang, Huijie; Yu, Jianzhong; Guo, Yunshan; Zhang, Zhengxing; Liu, Guoqi; Li, Jingjie; Zhang, Xiyang; Jin, Tianbo; Wang, Zhaoxia

doi:10.18632/oncotarget.13468

Cited by 10 publications

(2 citation statements)

References 32 publications

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“…Wang et al found that SNPs (rs8103163 and rs7248488) were associated with an increased risk of esophageal cancer ( Li et al, 2017 ). Our results showed a consistent direction of risk; SNPs of rs8103163 and rs7248488 in ZNF208 increased risk of LC in the Northwestern Chinese Han male ( Wang et al, 2016 ).…”

Section: Discussionsupporting

confidence: 72%

Genetic Variation in the ZNF208 Gene at rs8103163 and rs7248488 Is Associated With Laryngeal Cancer in the Northwestern Chinese Han Male

et al. 2022

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Background: Laryngeal cancer is more common in middle-aged and older men. We conducted an association analysis between ZNF208 polymorphisms and laryngeal cancer (LC) risk in the Northwestern Chinese Han male.Methods: A total of 352 subjects (172 LC patients and 180 controls) were involved in this study. Agena MassARRAY was used to determine the genotypes. Unconditional logistic regression analysis was performed to explore the relevance.Results: Two SNPs were associated with the risk of LC: rs8103163, OR = 1.41, p = 0.043; rs7248488, OR = 1.45, p = 0.025. Furthermore, rs8103163 was associated with an increased risk of LC under a log-additive model (OR = 1.40, p = 0.042), and rs7248488 was related to a higher risk of LC under a recessive model (OR = 2.33, p = 0.025) and a log-additive model (OR = 1.44, p = 0.026).Conclusions: We first demonstrated that the rs8103163 A allele and the rs7248488 A allele in ZNF208 create susceptibility to laryngeal cancer in the Northwestern Chinese Han male.

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Section: Discussionsupporting

confidence: 72%

Genetic Variation in the ZNF208 Gene at rs8103163 and rs7248488 Is Associated With Laryngeal Cancer in the Northwestern Chinese Han Male

et al. 2022

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“…PELO is a new HERsignaling regulator and was suggested to play a role in inhibiting tumor cell proliferation and metastasis (39,40). ZNF208 is a member of the zinc finger family of proteins and its mutations were found in many cancers, such as pancreatic cancer, gastric cancer, esophageal cancer and laryngeal cancer (41)(42)(43). We discovered its prognostic significance for breast cancer in our investigation.…”

Section: Discussionmentioning

confidence: 71%

The prognostic significance of human ovarian aging-related signature in breast cancer after surgery: A multicohort study

Xiao

Zhang²,

Cao³

et al. 2023

Front. Immunol.

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BackgroundRecent studies have shown that ovarian aging is strongly associated with the risk of breast cancer, however, its prognostic impact on breast cancer is not yet fully understood. In this study, we performed a multicohort genetic analysis to explore its prognostic value and biological features in breast cancer.MethodsThe gene expression and clinicopathological data of 3366 patients from the The Cancer Genome Atlas (TCGA) cohort, the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) cohort and the GSE86166 cohort were analyzed. A total of 290 ovarian aging-related genes (OARGs) were included in the establishment of the prognostic model. Furthermore, functional mechanisms analysis, drug sensitivity, and immune cell infiltration were investigated using bioinformatic methods.ResultsAn eight OARG-based signature was established and validated using independent cohorts. Two risk subgroups of patients with distinct survival outcomes were identified by the OARG-based signature. A nomogram with good predictive performance was developed by integrating the OARG risk score with clinicopathological factors. Moreover, the OARG-based signature was correlated with DNA damage repair, immune cell signaling pathways, and immunomodulatory functions. The patients in the low-risk subgroup were found to be sensitive to traditional chemotherapeutic, endocrine, and targeted agents (doxorubicin, tamoxifen, lapatinib, etc.) and some novel targeted drugs (sunitinib, pazopanib, etc.). Moreover, patients in the low-risk subgroup may be more susceptible to immune escape and therefore respond less effectively to immunotherapy.ConclusionsIn this study, we proposed a comprehensive analytical method for breast cancer assessment based on OARG expression patterns, which could precisely predict clinical outcomes and drug sensitivity of breast cancer patients.

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Gastrointestinal Cancers

Tabatabaiefar¹,

Moridnia²

2017

Cancer Genetics and Psychotherapy

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Genetic variants in the ZNF208 gene are associated with esophageal cancer in a Chinese Han population

Cited by 10 publications

References 32 publications

Genetic Variation in the ZNF208 Gene at rs8103163 and rs7248488 Is Associated With Laryngeal Cancer in the Northwestern Chinese Han Male

Genetic Variation in the ZNF208 Gene at rs8103163 and rs7248488 Is Associated With Laryngeal Cancer in the Northwestern Chinese Han Male

The prognostic significance of human ovarian aging-related signature in breast cancer after surgery: A multicohort study

Gastrointestinal Cancers

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