Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study

Yeates, Alison J.; Love, Tanzy; Engström, Karin; Mulhern, Maria S.; McSorley, Emeir M.; Grzesik, Katherine; Alhamdow, Ayman; Wahlberg, Karin; Thurston, Sally W.; Davidson, Philip W.; Wijngaarden, Edwin van; Watson, Gene E.; Shamlaye, Conrad; Myers, Gary J.; Strain, James J.; Broberg, Karin

doi:10.1016/j.plefa.2015.08.004

Cited by 40 publications

(46 citation statements)

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“…22 ). Maternal genetic variability may be a contributor to the maternal LC-PUFA status, but no evidence was revealed of its impact on the child's cognitive development as evaluated by Bayley Scales of Infant Development II test in a longitudinal observational study in high fish consumers at the age of 20-30 months 36 . In addition, breastfeeding or formula feeding status of the infant may interfere with defining the effect of pregnancy on the child's neurodevelopment 37 .…”

Section: Discussionmentioning

confidence: 99%

Perinatal nutrition impacts on the functional development of the visual tract in infants

et al. 2018

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BACKGROUND AND OBJECTIVE: We investigated the associations of maternal diet and serum fatty acids during pregnancy and in early infancy on infantile neurodevelopment. METHODS: Pattern-reversal visual evoked potentials (pVEP) as depictors of central nervous system maturation were recorded from 56 children when they were 2 years old. Maternal nutrient intakes were calculated from food diaries and fish consumption from questionnaires collected during pregnancy. Serum phospholipid fatty acids were determined by gas chromatography in late pregnancy and from infants at 1 month of age. RESULTS: The children of the women who consumed fish three or more times per week during the last trimester of pregnancy had a higher pVEP component P100 amplitude for 60′ (mean 23.4, SD 8.1) and 30′ (mean 20.4, SD 6.7) of arcminute check sizes compared to those who consumed fish 0-2 times per week (mean 15.0, SD 4.8, p = 0.023, adjusted for birth weight and gender p = 0.058 and mean 13.4, SD 2.0, respectively, p = 0.028, adjusted p = 0.072). Maternal and child serum phospholipid fatty acids correlated with child pVEP measurements. CONCLUSION: The results of this small-scale study suggest that fish consumption during pregnancy and perinatal serum fatty acid status may associate with neurodevelopment within visual system during infancy.Pediatric Research (2019) 85:72-78; https://doi.

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Section: Discussionmentioning

confidence: 99%

Perinatal nutrition impacts on the functional development of the visual tract in infants

et al. 2018

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“…polyunsaturated fatty acids or selenium) in fish and other seafood that may influence MeHg associations with developmental outcomes. (Strain et al, 2015) Finally, evidence is accumulating that genetics influencing the metabolism of MeHg (Julvez et al, 2013) and nutrients (Yeates et al, 2015) in fish may result in geographic variability in MeHg associations due to differences in the distribution of relevant genes in the different study populations.…”

Section: Discussionmentioning

confidence: 99%

Methyl mercury exposure and neurodevelopmental outcomes in the Seychelles Child Development Study Main cohort at age 22 and 24years

Wijngaarden

Thurston

Myers

et al. 2017

Neurotoxicology and Teratology

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Background All fish contain methyl mercury (MeHg), a known neurotoxicant at adequate dosage. There is still substantial scientific uncertainty about the consequences, if any, of mothers consuming fish with naturally-acquired levels of MeHg contamination. In 1989-1990, we recruited the Main Cohort of the Seychelles Child Development Study to assess the potential developmental effects of prenatal MeHg exposure. We report here on associations with neurodevelopmental outcomes obtained at 22 and 24 years of age. Methods Neurodevelopmental tests at 22 years included the Boston Naming Test, Cambridge Neuropsychological Test Automated Battery (CANTAB), and the Profile of Mood States. At 24 years, we administered the Stroop Word-Color Test, the Barkley Adult ADHD Rating Scale, the Test of Variables of Attention, and the Finger Tapping test. We also administered a healthy behaviors survey at both ages. Primary analyses examined covariate-adjusted associations in multiple linear regression models with prenatal MeHg exposure. In secondary analyses we also examined associations with recent postnatal MeHg exposure. Results We did not observe adverse associations between prenatal MeHg exposure and any of the measured endpoints. Some measures of attention, executive function, and delayed recall showed improved performance with increasing exposure. Secondary analysis did not show consistent patterns of association with postnatal exposure. Conclusions Our cohort has been examined at ten different ages over 24 years of follow-up. Findings suggest that prenatal and recent postnatal MeHg exposure from ocean fish consumption is not adversely associated with neurobehavioral development at levels that are about ten times higher than typical U.S. exposures.

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“…Indeed, the APOE4 allele, which is a well-known genetic risk factor of Alzheimer's disease, is involved in disrupted PUFA metabolism with a shift to long-chain n-3 PUFA oxidation [187, 188]. Genetic variability in fads (desaturases involved in the metabolization of PUFAs) is involved in the bioavailability of long-chain PUFAs AA and DHA to the brain, as well as brain development and cognitive impairment [189–192]. Polymorphism of several genes involved in PUFA metabolism or inflammation is crucial in the efficacy of dietary n-3 PUFA supplementation on inflammation and triglyceride blood level [193, 194].…”

Section: Risk Factors For Neuroinflammation and Autismmentioning

confidence: 99%

Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota

et al. 2016

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Several genetic causes of autism spectrum disorder (ASD) have been identified. However, more recent work has highlighted that certain environmental exposures early in life may also account for some cases of autism. Environmental insults during pregnancy, such as infection or malnutrition, seem to dramatically impact brain development. Maternal viral or bacterial infections have been characterized as disruptors of brain shaping, even if their underlying mechanisms are not yet fully understood. Poor nutritional diversity, as well as nutrient deficiency, is strongly associated with neurodevelopmental disorders in children. For instance, imbalanced levels of essential fatty acids, and especially polyunsaturated fatty acids (PUFAs), are observed in patients with ASD and other neurodevelopmental disorders (e.g., attention deficit hyperactivity disorder (ADHD) and schizophrenia). Interestingly, PUFAs, and specifically n-3 PUFAs, are powerful immunomodulators that exert anti-inflammatory properties. These prenatal dietary and immunologic factors not only impact the fetal brain, but also affect the microbiota. Recent work suggests that the microbiota could be the missing link between environmental insults in prenatal life and future neurodevelopmental disorders. As both nutrition and inflammation can massively affect the microbiota, we discuss here how understanding the crosstalk between these three actors could provide a promising framework to better elucidate ASD etiology.

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Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study

Cited by 40 publications

References 45 publications

Perinatal nutrition impacts on the functional development of the visual tract in infants

Perinatal nutrition impacts on the functional development of the visual tract in infants

Methyl mercury exposure and neurodevelopmental outcomes in the Seychelles Child Development Study Main cohort at age 22 and 24years

Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota

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